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Biomedical subjects

D Choudat

Publications and source records attributed to D Choudat.

49 records · Page 3Linked to original sources

[Etiological factors of asthma and their relation with bronchial hyperreactivity].

As asthma is nearly always associated with non-specific bronchial hyperreactivity, this factor has been considered to be an essential requirement for the development of symptomatic asthma. Some factors appear to be inducers of bronchial hyperreactivity and others promotors of asthmatic symptoms. In clinical practice, it is very difficult to classify aetiological factors as inducers or promotors: there is evidence to support the fact that the same factors may cause both bronchial hyperreactivity and asthmatic symptoms; conversely, the evidence for hereditary non-specific bronchial hyperreactivity is hardly convincing. These observations suggest that non- specific bronchial hyperreactivity is more a marker of bronchial asthma than a true aetiological factor.

Asthma↗

Serum activity of angiotensin converting enzyme and pulmonary radiography as prognostic criteria in sarcoidosis.

To compare the prognostic value of the serum concentration of angiotensin converting enzyme (SACE) to that of pulmonary radiography, patients with mediastino-pulmonary sarcoidosis were followed over two years and then retrospectively placed in one of 2 groups, designated "cured" (CS) or "not cured" (NCS) on the basis of clinical and biologic criteria. The two groups were then compared with respect to the initial pulmonary radiologic image, and the initial SACE concentration. The initial SACE concentration (CS: 45.6 +/- 15.4 U . ml-1; NCS: 48.5 +/- 27.3 U . ml-1; means +/- SD) and the percentage of patients with elevated SACE (CS: 75%; NCS: 69%) did not differ significantly between the two groups; on the other hand, the percentage of patients with pulmonary nodules on their initial chest film was higher in the NCS group (50%) than in the CS group (21%; p less than 0.05). We conclude that pulmonary radiography is the more reliable prognostic criterion in mediastino-pulmonary sarcoidosis.

Adult↗

[Presinusoidal portal hypertension in post-hepatitis cirrhosis].

Two cases of very probable post-hepatitis cirrhosis are presented. Both were complicated by presinusoidal portal hypertension (P. H. T.), the peroperative portal pressures measured directly being much higher than the wedged hepatic venous pressures. Although post-sinusoidal P. H. T. is the usual complication of most types of cirrhosis, these two cases support recent studies reporting the possibility of pre-sinusoidal P. H. T. in post-hepatitis cirrhosis. The wedged hepatic venous pressure is not a reliable indicator of portal pressure in these cases. The presence of presinusoidal P. H. T. does not exclude the diagnosis of cirrhosis but makes that of alcoholic cirrhosis very unlikely.

Adult↗

[Theoretical cost of the medical treatment of a case of tuberculosis in France in 1982].

The theoretical cost of the medical treatment of a case of tuberculosis in France in 1982 was calculated after considering the price of diagnosis, drugs, in-patient care and follow up. For exclusively out-patient (ambulatory) care, 9 months treatment was 10 times less expensive than a therapeutic regime which included a hospital/sanatorium stay of four months followed by a return home. The major differences of theoretical costs involved were more closely related to location of treatment rather than either the drugs chosen (as Rifampicin was always used), or the type of follow up over 9 months.

Ambulatory Care↗

[Periarteritis nodosa and carcinoma of the colon. A case report (author's transl)].

It is extremely rare to observe the simultaneous progression of periarteritis nodosa (PAN) and cancer. A patient was found to have histologically confirmed PAN shortly after excision of an adenocarcinoma of the descending colon. High levels of carcino-embryonic and then HbS antigens were discovered in the serum. A favorable medium-term result was obtained after corticoids and multiple cytotoxic chemotherapy. If one accepts that the typical vascular lesions of PAN are due to an antigen-antibody conflict producing circulating immune complexes, it is reasonable to suggest the hypothesis that many antigens could be involved in the production of immune complexes of this type. Many authors accept that HbS antigen is implicated, certain tumoral antigens may also play an analagous role.

Adenocarcinoma↗

[Pulmonary actinomycosis grafted on former tuberculous lesions. Report of one case (author's transl)].

The occurrence of actinomycosis localized in former tuberculosis cavities in a 39-year-old woman is reported. Exeresis of the lesions allowed the discovery of Actinomyces israelii in one of the cavities which no longer communicated with the bronchial tree. In contrast to diffuse actinomycosis found in immuno-depressed patients, this form of the disease was localized in a woman in good health. A decrease of pulmonary defense mechanisms could be involved locally. The infrequency of a tuberculosis-actinomycosis sequence, contrary to aspergilloma, is perhaps due to the anaerobic metabolism of the Actinomyces.

Actinomyces↗