Protection of mice against acute lethal graft-versus-host disease by treatment with anti-asialo GM1 antibody. Alopecia dermatitis in long-term survivors.
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Acute Disease↗
Biomedical subjects
D Cipriano
Publications and source records attributed to D Cipriano.
Evaluation of zinc complexes on the replication of rhinovirus 2 in vitro.
The effect of zinc salts and complexes were evaluated on the replication of rhinovirus 2 in vitro. Zinc chloride inhibited the replication of rhinovirus 2 at concentrations between 3 and 12 micrograms/ml. Influenza virus was not affected. A number of zinc complexes were tested and compared to zinc chloride. The results indicated that the activity and toxicity of all zinc complexes in the rhinovirus cytopathogenic effect (CPE) assay were directly related to the amount of unbound zinc available.
Cell Line↗
Split adjuvant technique.
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Adjuvants, Immunologic↗
Immunopotentiation of cell-mediated hypersensitivity by Corynebacterium parvum (Propionibacterium acnes).
We have investigated the activity of local Corynebacterium parvum (Propionibacterium acnes) as an immunopotentiator of allergic contact dermatitis (ACD) and photo-ACD in rodents. C. parvum given into the sensitization site, but not at a distance, increased the delayed-type hypersensitivity to the chemical allergen. An immunoadjuvant effect could be realized even when C. parvum was given several days after allergen; it was readily obtained in B cell-deficient mice. Cyclophosphamide pretreatment heightened the immunopotentiation seen with local C. parvum. It is unlikely that the specific immunopotentiation by C. parvum is mediated by enhanced macrophage processing of antigen, as proposed by others, since C. parvum immunostimulation occurs just as well 2 days after allergen as on the same day as allergen. We hypothesize that a major mechanism of C. parvum immunopotentiation is the inhibition by stimulated macrophages of the generation of specific T suppressor cells.
Animals↗