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Biomedical subjects

D Clayson

Publications and source records attributed to D Clayson.

14 recordsLinked to original sources
PubMed1987

Effects of antioxidants on aflatoxin-induced hepatic tumors in rats.

Female Wistar rats pretreated with Aflatoxin B1 (AFB) were administered reduced glutathione, butylated hydroxytoluene, methionine or ascorbic acid on a daily basis, p.o., for 8 months. None of the treatments produced a decrease in incidence or size of hepatic nodules. While there was some evidence that ascorbic acid reduced the incidence of cystic cholangioma, the ascorbic acid and methionine treatment groups also contained significantly fewer animals surviving to the 26-month sacrifice. The lack of effect of glutathione is not consistent with previous work showing a marked glutathione dependent regression of AFB-induced hepatocellular carcinoma.

Aflatoxin B1↗
PubMed1987

Long-term psychological sequelae of surgically versus nonsurgically treated scoliosis.

Forty-six female scoliosis patients (21-34 years of age) were tested psychologically 4 or more years following treatment. Twenty-three had been treated by bracing (Group A) and 23 by posterior spinal fusion (Group B). Variables evaluated were: self-esteem, capacity for intimacy, sexual satisfaction, and mental representation of the patient's own body (body image). The prediction that normal controls would show better psychological adjustment than scoliotic women--surgically treated or not--was only partially borne out. Contrary to expectations, both groups of scoliotics showed higher levels of sexual satisfaction than controls. Group B showed a greater need for intimacy and better sexual adjustment, self-esteem, and body image than Group A.

Adult↗
PubMed1982

Toxicological procedures for assessing the carcinogenic potential of agricultural chemicals.

Pesticides and other agricultural chemicals are now widely used throughout the world as a means of improving crop yields in order to meet the increasing demands being placed upon the global food supply. In Canada, the use of such chemicals is controlled through government regulations established jointly by the Department of Agriculture and the Department of National Health & Welfare. Such regulations require a detailed evaluation of the toxicological characteristics of the chemical prior to its being cleared for use. In this paper, procedures for assessing the carcinogenic potential of agricultural and other chemicals are discussed. Consideration is given to both the classical long-term in vivo carcinogen bioassay in rodent or other species and the more recently developed short-term in vitro tests based on genetic alterations in bacterial and other test systems.

Animals↗
PubMed1980

Personality development and familial dysautonomia.

The study sought to establish baselines for personality and frequency of psychopathology in familial dysautonomia (FD). Fifty FD patients, aged 6 to 28 years, served as subjects. FD subjects in all age ranges manifest neurotic patterns, but show no greater incidence of more severe pathology than is found in the general population. the arrested psychologic development seen in FD is described, together with the phenomenon of periodic lapses in judgment. The organic impairment of cognitive functions is discussed. Recommendations for treatment are proposed.

Adolescent↗
PubMed1979

Intellectual development and familial dysautonomia.

The study examined adaptive trends in cognitive development among individuals with familial dysautonomia and sought to establish new base rates of intelligence for the dysautonomic population. Fifty-two subjects, aged 6 to 28 years, were administered the Wechsler scales of intelligence. The results indicate that there is less cognitive impairment than previous research would suggest, and that more dysautonomic children are capable of adjusting to standard school programs than was heretofore thought possible. Specific deficits seen in this population are discussed along with a rationale for deleting the term retarded where most of these individuals are concerned.

Adolescent↗
PubMed1976

Adolescent scoliosis patients. Personality patterns and effects of corrective surgery.

Personality patterns of 84 adolescent scoliosis patients were assessed and an evaluation made of certain psychological effects of corrective surgery. Results indicate the following: Scoliosis has fewer psychologically debilitating effects on younger adolescents (those under 16) than it does on older adolescents; scoliotic boys show comparatively better general personality integration than girls; scoliotic girls are less disturbed in psychosexual development than are boys. Postoperatively, boys can be expected to show less overt incapacitation than girls; psychologically, boys will require a longer period of recuperation than will girls; boys can be expected to present fewer immediate management problems than girls; the internalization of a sense of "difference" from the normal in adolescent scoliotics increases in direct relation to age. Consequently, the eariler surgical correction can be undertaken the better. Important differences exist between the psychological "set" of male and female adolescent patients. For boys, self-acceptance is at the core. Postoperative surgical care should thus focus on reinforcing characteristics of personal adequacy, namely, the ability to compete, and fulfill reasonable goals. For girls, acceptance by others is paramount. Postoperative care is best directed toward strengthening feelings of attractiveness (of any personal characteristic), worth, and, above all, future interpersonal possibilities.

Adolescent↗
PubMedDate not supplied

Preoperative personality characteristics as predictors of postoperative physical and psychological patterns in scoliosis.

Four adaptive personality characteristics (trait anxiety, active--independent orientation, emotional poise, and level of cognitive development) were evaluated preoperatively in 50 adolescent idiopathic scoliosis patients undergoing spinal surgery. Postoperatively, three indices of physical recovery (quantity of analgesics taken, elimination difficulties, and number of days to discharge) and two of psychological state (anxiety and depression) were rated. Two of the four adaptive personality characteristics correlated significantly with postoperative physical and psychological reactions. Quantity of analgesics taken, elimination difficulties, anxiety, and depression were significantly related to (viz., predicted by) preoperative trait anxiety. Quantity of analgesics taken and anxiety were significantly related to level of cognitive development. Preoperative degree of curvature was significantly related to postoperative quantity of analgesics taken. Duration of the scoliosis was significantly associated with level of cognitive development, but not with postoperative physical or psychological adjustment.

Adolescent↗