The treatment of primary biliary cirrhosis.
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Biomedical subjects
Publications and source records attributed to D Clements.
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Features of rejection were found in 21 needle biopsies obtained from seven patients after liver transplantation. Wedge biopsies taken peroperatively were used as a baseline for comparison. Rejection was diagnosed by excluding other known causes of graft dysfunction using appropriate methods. In cases in which these criteria were fulfilled a consistent picture of rejection was seen, and this was useful in clinical management. Two features constantly present in cases of acute rejection were: a dense mixed portal inflammatory infiltrate; and polymorphonuclear infiltration of biliary epithelium.
We describe a new modified method of producing non-obstructive complete internal biliary retention in the rat by draining bile into the caudal vena cava. This relatively simple method has the additional advantage that restraining cages are not necessary.
The last 20 years have seen progressive developments in the field of clinical transplantation and in many countries kidney transplantation is now the most cost effective manner of treating renal failure. With increasing technical experience failures have become less common and newer immunosuppressive protocols incorporating cyclosporin A can frequently achieve a graft success rate of over 75% at one year with patient survival over 95%. In addition, the patient receiving a kidney graft attains a high quality of rehabilitation. If renal transplantation has now gained wide acceptance other forms of organ transplantation are still in a phase of development and have not yet reached wide acceptance. It is the purpose of this review to present briefly the current clinical status of two forms of solid organ transplantation being employed in clinical practice.
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