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D Collin

Publications and source records attributed to D Collin.

17 recordsLinked to original sources
PubMed1991

[The corpus luteum and progesterone secretion].

The pulsatility of LH secretion has been known only since 1970. The pulsatility of progesterone secretion has now also been shown. The frequency and amplitude of these pulses vary during the three phases of the luteal period. The first or early luteal (EL) phase lasts four days starting from the peak of LH. There is no pulsatility of progesterone during EL. The frequency of LH pulsatility is 103 +/- 8 minutes. The second or mid luteal (ML) phases, from +6 to +9 days after the peak of LH, is characterised by pulses of LH and of progesterone, most often in positive crossover correlation and with 7 to 14 pulses per 24 hours. The frequency of LH pulsatility is 166 +/- 33 minutes according to Filicori. The amplitude of LH secretion is 4 to 40 ng/ml. The third or late luteal (LL) phase, occurring at +11 days before the menstrual period, has the same characteristics in terms of quality but shows variations in frequency and amplitude towards a decrease. Thus the amplitude of progesterone secretion is 2.8 to 9 ng/ml (Veldhuis). In the opinion of clinicians, the corpus luteum is independent up to LH+ 5 days. The injection of hCG during this time is ineffective. A single progesterone level is sufficient if the result is 10 ng/ml or more. The problem remains complex concerning results below 10 ng/ml. The solution suggested for the present is that described by Olive: during ML and/or LL, three samples in the morning at hourly intervals and two endometrial biopsies during two consecutive cycles.

Biopsy↗
PubMed1989

[Attempted analysis of the progressive development of prematurity between 1980 and 1985 at the maternity hospital in Haguenau].

The recent increase of premature births has led the authors to conduct an exhaustive, prospective investigation from computerized data, including 8,618 pregnant women who delivered at the Maternity Hospital in Haguenau between January 1980 and December 1985. Their results disclose a significantly increased ratio of premature births in the gravida I group and in women with a primary level of education, who were followed by a general practitioner. On the other hand, the ratio of premature births at 34 weeks and less, is also increased in people followed by a general practitioner, which is not the case for induced prematurity. These results, although preliminary, prompt the consultant to reconsider primary prevention in these groups with particular risks.

France↗
PubMed1988

[Prevention of prematurity: Haguenau perinatal survey, 1971-1985].

A preterm birth prevention program was instituted in France in the early 1970s. Its effectiveness has been assessed through a perinatal study in Haguenau. A relationship between prenatal care improvement and preterm birth rate decrease was noted, but a causal interpretation cannot be derived from such an observational study. However, some arguments do support this interpretation: no satisfactory alternative explanation (such as biases in pregnancy duration measurement, change in the composition of the population of pregnant women, or secular trend), a plausible causal pattern, and a dose-response relationship between prenatal care and preterm birth rate. The Haguenau study results can be applied to other French regions, but extrapolation to other countries would depend on their social, medical and cultural contexts.

Female↗
PubMed1986

Women's acceptance of a preterm birth prevention program.

A major modification in French national perinatal policy was proposed in 1970. Its primary aim was to reduce preterm births, and a specific program has been progressively applied to all pregnant women in France since 1971. Because the policy was introduced at a national level, it was possible to use a district hospital in Haguenau (northeastern France) as an observation site for measuring the effects of the change. A longitudinal study was begun in 1971 and continued for 12 years, during which time a total of 16,004 singleton pregnancies were followed. This article focuses on acceptance by the pregnant women in Haguenau in response to the new prenatal care proposals. A major reduction in preterm births is demonstrated, and the relationship between acceptance and observed changes in preterm birth is discussed. Certain time-related patterns were observed: it took time for the policy modification to be measurable; while the outcomes showed general improvement, results were closely related to the patient's social status; there were significant time-lag differences between social class groups with regard to acceptance of specific interventions.

Birth Weight↗
PubMed1986

Spontaneous abortion and interpregnancy interval.

Analysis of 8972 pregnancies and 5089 interpregnancy intervals, computer-registered over 12 years at the Haguenau Hospital Maternity Department, showed that the length of interpregnancy interval may be considered as a risk factor in spontaneous abortion; this was still true after other important known risk factors, i.e. maternal age, parity, previous spontaneous abortion and contraceptive practice, had been taken into account. However, separate analysis of pregnancies according to whether they occur more or less than 1 year after contraception (if used) had been stopped showed that the relationship between a long interval and spontaneous abortion was only significant for subfertile women who took longer than 1 year to conceive. This supports the hypothesis that the same mechanism is involved in the aetiologies of spontaneous abortion and of difficulty in conceiving.

Abortion, Spontaneous↗
PubMed1986

Precocious cervical ripening and preterm labor.

A group of 8303 women was studied to determine the timing of cervical ripening. It was confirmed that these signs of cervical change can be observed several weeks before preterm births. The precocious signs of external ripening can be recognized during a vaginal examination and may be useful in predicting preterm labor.

Cervix Uteri↗
PubMed1986

[Results of 4 years' use of oxytocin and prostaglandins F2 alpha for ripening with postterm indications after the 41st week of amenorrhea].

The authors report a comparative study between the maturing and induction technique by prostaglandins F2 alpha and pitocin, and a reference population in spontaneous labor in extended pregnancies after 41 weeks and more of complete amenorrhea. It appears from this study that the severe fetal pathology linked to post-maturity has completely disappeared, but at the price of a higher rate of cesarean sections no matter which technique was used: pitocin or prostaglandins.

Dinoprost↗
PubMed1986

[The artificial induction of labor. Study of methods].

Three methods deserve mentioning: on the one hand, administration of pitocin and prostaglandins, on the other hand, artificial rupture of the membranes. The authors are proposing a practical plan of these various indications.

Amnion↗
PubMed1986

Maturation signs of the cervix and prediction of preterm birth.

A prospective study was conducted on 7937 pregnancies, 4430 of which had prenatal visits before 37 weeks of gestation. Induced preterm deliveries were excluded (N = 40). Then the data was incorporated from the visits (cervix status, uterine contractions) as well as some common indicators of risk for preterm birth (mother's age, social status, obstetric antecedents, bleeding) into a predictive scoring system for spontaneous preterm labor. Different scores were computed according to both parity and to the timing during pregnancy when the signs were observed. It was found that approximatively 25% of the total preterm births were connected with the presence of at least one of three maturation signs of the uterine cervix (dilation of the internal os to 1 cm, cervical length less than 1 cm, and presence of painful uterine contractions).

Adolescent↗
PubMed1985

Prevention of preterm births: a perinatal study in Haguenau, France.

A reduction in preterm births has been observed in Haguenau (Eastern France) during a 12-year intervention study with a program for prevention of preterm deliveries. The Perinatal Study of Haguenau was an observation tool used in a stable population, and it allowed measurement of the way women have progressively responded to the new proposals in prenatal care. It also allowed measurement of the results of the interventions: low birth weight (less than 2,500 g) and preterm birth rates (less than 37 weeks of gestation) among single live births. The total duration of the study was divided into three periods of four years (1971 through 1974, 1975 through 1978, and 1979 through 1982), for which the numbers of single live births are 5,763, 4,957, and 5,919, respectively. For the same periods, the low-birth-weight rates, 4.6%, 4.0%, and 3.8%, respectively, showed a significant decrease (P less than .001). Following a similar pattern, the rates of preterm birth were 5.4%, 4.1%, and 3.7% (a significant reduction with P less than .001). These improvements in pregnancy outcome do not disappear after standardization of mother's age, high blood pressure, or social class distribution. These findings, which concur with the results of others, enhance the hypothesis of a direct relationship between a prevention program and a reduction in preterm birth rates.

Birth Weight↗
PubMedDate not supplied

[Prolonged pregnancy and perinatal distress].

212 out of 2806 women who delivered in the Haguenau Maternity had a period of amenorrhoea markedly longer than 42 weeks, when the menstrual cycle was 28 +/- 8 days. 39 of the 212 pregnancies, which means 18 per cent of the infants, showed signs of postmaturity and in these there was an excess of fetal distress. Those children who were born after pregnancies which were theoretically "prolonged" but did not show signs of postmaturity did not suffer neonatal distress any more than those children born at term. Having scans of uterine growth makes one come to the conclusion that these are not really prolonged pregnancies.

Female↗