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Biomedical subjects

D Conen

Publications and source records attributed to D Conen.

83 records · Page 5Linked to original sources
PubMed1981

[Haemoccult and Colorectal: a comparative prospective study on the detection of occult blood in the feces].

Comparison of Colorektal and Haemoccult in 600 stool samples from 200 ambulatory, non-selected patients over the age of 40 revealed an equal number of positively reacting specimens (Colorektal 5.8%, Haemoccult 5.7%). Comparison of the results in relation to patients showed 28 positive cases with Colorektal and 18 with Haemoccult. Diagnostic workup disclosed a lesion potentially responsible for the bleeding in 67% of the cases with Haemoccult-positive and 54% with Colorektal-positive stool samples.

Adult↗
PubMed1981

[Nine cases of imported Malta fever in Basle].

Report on 9 cases of Malta fever seen in Basle, Switzerland, in the first three months of 1980. In contrast to previous reports in the literature, positive blood cultures were found in 8 of the 9 patients. All were infected by direct contact with sheep and the clinical picture was classified in all cases. Therapy with Doxycyclin led to rapid improvement. No severe complications were observed. In the light of these cases the epidemiology, clinical picture, possible complications and therapy of this disease are discussed.

Adolescent↗
PubMed1981

[Evaluation of pharmacotherapy in general-internal ambulatory care as a possibility of quality control].

The therapeutic process at a medical outpatient clinic is evaluated. 1800 drug prescriptions for 839 patients issued by 9 medical residents from February to March 1980 were collected prospectively and analyzed by retrospective chart review. Although a rather high frequency of drug prescription (0.83 per consultation) was found, the average of 2 drugs per patient treated was considered to be low. Gastrointestinal drugs were prescribed most frequently (17% of all prescriptions), whereas antimicrobial agents (7%), psychotropic drugs (10%) and cerebrovascular vasodilators (0.8%) were used rarely in comparison with the results of other investigations. Evaluation of choice of drugs and frequency of their use was based on criteria from the literature. Analysis of prescribing patterns of the individual residents provided information about their pharmacotherapeutic peculiarities. Drug use of the group was judged to be satisfactory. The accuracy of the diagnostic workup preceding drug therapy was examined, and for 17% of all prescriptions no diagnosis could be found in the medical record. Furthermore, the chart review revealed unsatisfactory documentation of the drug therapy prescribed, i.e. 20% of prescriptions were not recorded. Educational feedback to the group was given to the residents. It was accepted as valuable information about medical behaviour and performance of the individual.

Ambulatory Care↗
PubMed1979

[The echocardiogram in mitral anulus calcification].

In agreement with the known high incidence of mitral anulus calcification in elderly patients, the authors have found corresponding calcifications in echocardiographic examinations in 61 patients as the single or additional cause of an abnormal systolic or diastolic murmur. The intracardiac calcifications were known of from the chest X-ray only in 6 patients. The echocardiograms served to locate and estimate the amount of the calcification. Calcifications of the aortic cusps, found in 75% of patients, may be of degenerative origin. The echocardiographic presentation of the degenerative calcifications can be misinterpreted either as postrheumatic valvular disease, posterior pericardial effusion or hypertrophic cardiomyopathy. Registration by continuous sector scan was necessary to differentiate these entities.

Aged↗
PubMed1979

[Hemolytic crisis and acute kidney failure from rifampicin].

Two cases are reported of hemolytic crisis and acute anuria after intermittent rifampicin medication. Immunologic tests demonstrate that the hemolysis was of the drug-induced heteroimmune type whereas the pathogenesis of the anuria was uncertain. For both complications the prognosis is good.

Acute Kidney Injury↗
PubMedDate not supplied

A skin test for autonomic neuropathy.

Intradermal injection of 0.5 microgram histamine produced equal skin reactions in normal individuals (n = 15) and in diabetic patients with (n = 10) or without (n = 9) evidence of autonomic neuropathy as well as in patients after lumbar sympathectomy (n = 5). Addition of noradrenaline (0.1 microgram) resulted in a significantly smaller skin reaction (mean +/- SEM) in normal (101.9 +/- 10.1 vs. 136.3 +/- 6.5 mm2, p less than 0.005) and in diabetic patients without autonomic neuropathy (101.8 +/- 8.4 vs. 123.9 +/- 8.7 mm2, P less than 0.05), but remained unchanged in diabetic patients with autonomic neuropathy (131.0 +/- 9.0 vs, 130.7 +/- 8.2 mm2, n.s.) and after lumbar sympathectomy (135.2 +/- 17.5 vs 130.2 +/- 19.6 mm2, n.s.) when compared with the reaction to histamine alone. Addition of terbutaline produced similar results as observed with noradrenaline. These findings suggest a defect at the adrenoceptor level in diabetic patients with autonomic neuropathy and in patients with lumbar sympathectomy. Thus, the combined intradermal injection of histamine and the adrenoceptor agonists noradrenaline or terbutaline represents a simple and useful test for identifying patients with impaired adrenergic function.

Adult↗