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Biomedical subjects

D Conte

Publications and source records attributed to D Conte.

At least 145 records · Page 8Linked to original sources
PubMed1984

Secretin-induced gastrin response in the Zollinger-Ellison syndrome and chronic duodenal ulcer patients before and after cimetidine treatment.

A secretin provocative test was performed in 16 patients with chronic duodenal ulcer and in five patients with the Zollinger-Ellison syndrome. In four chronic duodenal ulcer patients a second secretin test was done during acute iv cimetidine administration. There were only slight variations of gastrin compared with the first test. A third test was done on the same four chronic duodenal ulcer patients after 1 month's po cimetidine treatment (1 g/day); gastrin at 0 time was significantly higher than in the previous two tests (p less than 0.01). Integrated gastrin response after secretin was significantly lower in the third test than in the first (p less than 0.05). In two Zollinger-Ellison syndrome patients treated with 1.0 and 1.4 g/day cimetidine for 3 months, gastrin at 0 time was not markedly increased, whereas compared with the first test gastrin levels were higher at each time after secretin. These data suggest that previous cimetidine treatment does not alter, and may even increase, the diagnostic sensitivity of the secretin test.

Adolescent↗
PubMed1983

Effects of somatostatin infusion in four patients with malignant carcinoid syndrome.

Somatostatin (4 micrograms/min, cyclic form) was infused for 24 h on six occasions in four patients with carcinoid ileal tumor and multiple liver metastases. During infusion, spontaneous flushes and/or diarrhea were markedly reduced with a return to the pretreatment pattern on the next day. Urinary 5-hydroxyindole acetic acid excretion and plasma gastrin were not significantly changed, whereas plasma insulin presented the expected decrease and rebound. These results confirm that carcinoid symptoms are somatostatin-sensitive but do not provide evidence that serotonin or gastrin play a major role in inducing these symptoms.

Aged↗
PubMed1982

Thrombolytic therapy for venous thrombosis in patients with gastro-intestinal diseases.

Venous thrombosis in 2 patients with gastro-intestinal diseases (chronic liver disease and ulcerative colitis) is reported. A good clinical improvement was obtained after thrombolytic (urokinase) therapy without any haemorrhagic side-effect. A decrease in the plasma of the fast-acting antiplasmin has been correlated with urokinase thrombolytic effect in vivo. These preliminary reports suggest that thrombolytic drugs are a safe tool for the treatment also of thromboembolic complications in patients with potential haemorrhagic diathesis.

Aged↗
PubMed1981

[Evaluation of hematometric parameters and plasma ferritin levels in patients treated with ferritin-containing preparations].

Ferritin has been administered in immediately bioavailable solution form, and in solid form, with exclusively duodenal bioavailability, to two groups of patients suffering from sideropenic dyserythropoietic anaemia. The results obtained point to a significant stimulating action on erythropoiesis documented by the increase in reticulocytes and red cells. This increase is certainly relatable to the increase of available iron and to its incorporation in the erythrocytes, as demonstrated by the increase in ferritinaemia, sideraemia, haemoglobin and mean corpuscular haemoglocbin concentration. The data obtained showed the bioavailable fluid form to be more active than the solid.

Anemia, Hypochromic↗
PubMed1981

Treatment of radiolucent gallstones with CDCA or UDCA. A multicenter trial.

Patients with radiolucent gallstones (diameter less than 1.5 cm) and functioning gallbladder were treated for 6-12 months with CDCA (38 patients, 12-15 mg/kg/day) or UDCA (78 patients randomly allocated to receive 5-6 or 10-12 mg/kg/day). Complete dissolutions and partial plus complete dissolutions were respectively 26 and 58% for CDCA, 14 and 58% for UDCA at the lower dose, and 29 and 71% for UDCA at the higher dose. Statistical analysis did not show any significant difference between the three different treatments. In patients with stones of 4-10 mm diameter treated with UDCA, complete dissolution occurred at the lower dose in 0 of 14 cases while complete dissolutions occurred at the higher dose in 5 of 18 cases, suggesting that the latter dose may be more effective (0.05 less than P less than 0.1). A highly significant correlation was demonstrated between gallstone size and number of dissolutions with both doses of UDCA. No side effects were observed with UDCA, while with CDCA diarrhea occurred in 28% and a transient increase in SGOT in a single patient. 1 patient on UDCA required emergency cholecystectomy for acute cholecystitis. Dyspeptic and/or pain symptom-atology improved in 65 and 85% of the patients treated with CDCA and UDCA, respectively. No variations in the blood lipids were observed.

Adult↗
PubMed1981

Radiolucent gallstone dissolution with bedtime UDCA administration.

26 patients (20 females and 6 males, mean age 40.5 years +/- SEM 2.20, mean weight 60.2 kg +/- 1.98) with radiolucent gallstones of diameter less than or equal to 10 mm were treated for 6 months with ursodeoxycholic acid (UDCA), a single dose of 600 mg at bedtime. The rate of partial + complete dissolutions was 85%, reaching 100% for gallstones of less than 4 mm diameter. No side effects were observed. In a similar series of patients treated with UDCA t.i.d. at mealtimes (10--12 mg/kg/day) a slightly lower dissolution rate was obtained but the difference was not statistically significant.

Adult↗
PubMed1979

Relationship between seminal PGE and 19-OH PGE and seminal fructose in man.

Seminal PGE, 19-OH PGE and fructose were assayed in normal volunteers and in infertile patients. From data obtained it appears that seminal PGE are probably not synthesized exclusively at seminal vesicles level since no relationship was observed between PGE and fructose. On the other hand the seminal vesicles appear to be the preferential site of seminal 19-OH PGE production since a close relationship was observed between 19-OH PGE and fructose in those case in which these prostaglandins were below minimum normal values. Various hypotheses are advanced in order to interpret the lack of correlation in the presence of high 19-OH PGE levels.

Fructose↗
PubMed1977

[Progressive external ophthalmoplegia and disorders of ventricular conduction. Apropos of 3 recent cases].

The authors report 3 cases with an association of progressive external ophthalmoplegia (OEP) and disordered intracardiac conduction. These cases, and the twenty or so similar ones reported in the literature, show that this association is important for two reasons:--there is a therapeutic importance in that the condition affects young patients, who are at risk from sudden death due to the conduction defect; for this reason electrocardiographic follow-up must be regular, and an intracavitary pacemaker must be introduced definitively at the least indication;--there is a physiopathological importance in that the effect of the myopathies on the myocardium is well known, but most information relates to the diffuse cardiomyopathies, and in only 10% of cases are there conduction defects. By contrast, the conductive tissue appears to be involved in all cases of OEP, while cardiac failure is rare. It seems likely, therefore, that cases of OEP have a pathogenesis different from that of the diffuse myopathies, whether or not these involve the external occular muscles.

Adult↗