Hypolaetin-8-O-glucoside, an anti-inflammatory flavonoid from Sideritis mugronensis.
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Anti-Inflammatory Agents↗
Biomedical subjects
D Cortes
Publications and source records attributed to D Cortes.
Angiotensin-converting enzyme: an indicator of bleomycin-induced pulmonary toxicity in humans?
In order to evaluate bleomycin-associated lung damage in humans, lung function parameters and serum levels of the endothelial-bound angiotensin-converting enzyme (ACE) were determined by serial measurements in 11 patients who were treated for testicular cancer. None developed clinical or radiological evidence of pulmonary damage. While the static and dynamic lung function parameters were unchanged, carbon monoxide diffusion capacity (DLCO) decreased significantly (P less than 0.01) during a total of 126 days of pulsed regimen, indicating damage to the alveolar-endothelial membrane. S-ACE was unchanged within each treatment course but increased significantly (P less than 0.05) from the initial value to the last treatment course. Two months after cessation of treatment S-ACE returned to pretreatment values. Although the changes were modest they might mirror treatment-associated endothelial damage.
Adolescent↗
[Norstephalagine and atherospermidine: two smooth muscle relaxant aporphines from Artabotrys maingayi].
Nine isoquinoline alkaloids have been isolated from the bark of Artabotrys maingayi: four noraporphines (norstephalagine, 3-hydroxynornuciferine, anonaine, and nornuciferine), one 7-hydroxyaporphine (ushinsunine), three oxoaporphines (atherospermidine, liriodenine, and lysicamine), and one protoberberine (discretamine). The effects of the main alkaloids, norstephalagine and atherospermidine, have been studied on the Ca-dependent contractile activity of smooth muscle (uterus). Both norstephalagine and atherospermidine show relaxing activity on rat uterine contractions induced by KCl or rhythmic contractions induced by oxytocin in the presence of Ca, but only atherospermidine can relax oxytocin- or vanadate-induced contractions in a Ca-free medium.
Animals↗
[Isolation and synthesis of espintanol, a new antiparasitic monoterpene].
The in vitro leishmanicidal and trypanocidal activities of a petroleum ether extract of Oxandra espintana have been investigated. Four aromatic monoterpenes were isolated, of which two are novel: espintanol [3a], responsible for the antiparasite activity, and O-methylespintanol [4]. Espintanol was tested in vitro on 20 strains of Trypanosoma cruzi and 12 strains of Leishmania spp. Its structure was determined by spectroscopic methods and confirmed by its preparation starting from carvacrol.
Animals↗
Cytotoxic compounds from Annonaceus species as DNA topoisomerase I poisons.
BACKGROUND: In the search for cytotoxic natural products as DNA topoisomerase poisons, we have assessed six annonaceus compounds (the acetogenins annonacin and rolliniastatin-1, the styryl-lactones etharversin and altholactone and the alkaloids thaligrisine and cepharanone-B) for cytotoxic activity against three human cancer cell lines and then we evaluated these compounds as DNA topoisomerase poisons. MATERIALS AND METHODS: The cytotoxicity parameters were determined following protocols established by the National Cancer Institute (NCI) using the SRB assay. In the topoisomerase assay, the supercoiled DNA produces open circle forms that are stabilised in the presence of DNA topoisomerase poisons and can be detected after a denaturation step by proteinase K-SDS. RESULTS: The six compounds showed cytotoxic activity, with cepharanone B being the most cytotoxic one, even more than the antineoplastic agent etoposide on two cancer cell lines, although it is the only one that does not act as a DNA topoisomerase poison. CONCLUSION: These results could justify the traditional use of the studied annonaceus species and topoisomerase-mediated DNA damage might be a possible mechanism by which five of these compounds exert their cytotoxicity.
Annonaceae↗
Antioquine: a new bisbenzylisoquinoleine alkaloid with calcium antagonist activity.
The objective of this work was to examine the smooth muscle relaxing properties of antioquine, compared to papaverine, in isolated rat uterus. The results obtained show that both antioquine and papaverine are capable of relaxing sustained contractions induced by Ca2+ in K-depolarizing solution as well as the spontaneous activity of rat uterus. Antioquine (0.1 mM, 0.5 mM and 1 mM) also induces a displacement to the right of the dose-response curves to Ca2+, and the antagonism was not competitive. Papaverine produced a decrease in the frequency and amplitude of contractile responses induced by oxytocin, and these inhibitory effects were observed regardless of whether papaverine was added before or after the induced contractions. On the other hand, antioquine only modified the frequency of contractile responses to oxytocin or desynchronized cumulative dose-response curves to oxytocin when the uterus was preincubated with this alkaloid before addition of the agonist. These experiments suggest that the relaxant effects produced by antioquine may be due to the blockade of calcium movements across the cell membrane, mainly through voltage-operated channels, whereas papaverine affects Ca2+-entry both through VOCs and through ROCs.
Alkaloids↗