Control of cellular reactions by enzymic substrate perturbation.
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Cell Biology↗
Biomedical subjects
D Crişan
Publications and source records attributed to D Crişan.
Nucleolar organizer regions (AgNORs) in intraepithelial neoplasia of the uterine cervix.
The authors have studied the AgNORs counts in intraepithelial lesions of the uterine cervix. The following values were obtained (mean +/- SD AgNORs/cell): normal specimens--2.11 +/- 0.98; mild dysplasia--2.83 +/- 1.12; moderate dysplasia--3.42 +/- 1.13; severe dysplasia--3.55 +/- 1.28; carcinoma in situ--4.63 +/- 1.34; glandular extensions of carcinoma in situ--4.64 +/- 0.98. The values in moderate and severe dysplasia were similar, an argument for grouping these categories in the high-grade lesions. AgNORs counts in carcinoma in situ were, however, higher than in severe dysplasia, suggesting a continuous evolution of the neoplastic process.
Female↗
Morphometric investigations on bone giant cell tumors.
The authors have studied 12 cases of bone giant cell tumors and have shown that the increase in aggressiveness is accompanied by higher values of mitotic activity and nuclear features (area, perimeter, long and short axes), which might be useful for grading the bone giant cell tumors.
Bone Neoplasms↗
Carcinosarcoma (malignant mesodermal mixed tumor) or urinary bladder.
The authors report a case of carcinosarcoma (malignant mesodermal mixed tumor of the urinary bladder. We discuss the histological criteria of positive and differential diagnosis, the histogenesis, as well as their biological behavior.
Carcinosarcoma↗
Computer-based image analysis of nucleoli in prostate carcinoma.
The authors have evaluated the nucleoli in 37 cases of prostatic carcinoma. The increase in Gleason's grade 1 correlated with an increase in the percentage of nucleolated nuclei. The increase in the percentage of bi- and trinucleolated nuclei was accompanied by a decrease of the uninucleated nuclei. The values of morphometrical parameters studied in the individual nucleoli (area, perimeter, diameters) increased in Gleason grade 2 tumors as compared with grade 1 tumors. In tumors higher grades there was, however, a progressive decrease of these values.
Cell Nucleolus↗