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D Crozier

Publications and source records attributed to D Crozier.

At least 19 recordsLinked to original sources
PubMed2001

XAFS at the Pacific Northwest Consortium-Collaborative Access Team undulator beamline.

The Pacific Northwest Consortium-Collaborative Access Team (PNC-CAT) has begun operating an insertion device beamline at the Advanced Photon Source. The beamline has been extensively used for XAFS studies. This paper summarizes its capabilities, and our initial operational experience. The beamline is based on APS undulator A, and incorporates full undulator scanning. The monochromator is liquid nitrogen cooled and has both Si(111) and Si(311) crystals in a side-by-side configuration. Crystal changes only take a few minutes. The crystals cover the energy range from 3-50 keV with fluxes as high as 2x10(13) ph/sec. Microbeams can be produced using Kirkpatrick-Baez mirrors (spot size 1-3 microm) or tapered capillaries (sub-microm spots). When these optics are combined with a 13-element Ge detector, the beamline provides powerful microbeam imaging and spectroscopy capabilities. Experimental examples from the environmental field and in-situ UHV film growth will be discussed.

Journal Article↗
PubMed1980

Immunoassay of serum conjugates of cholic acid in cystic fibrosis.

Pre- and post-prandial serum conjugates of cholic acid (SCCA) were measured by radioimmunoassay (RIA) in 83 patients with cystic fibrosis (CF), 14 of whom did not have steatorrhoea, and in 25 controls. Of the CF patients with steatorrhoea, 38% had fasting SCCA levels greater than 3 standard deviations above mean fasting control values, whereas no CF patient without steatorrhoea had elevated fasting SCCA levels. Steatorrhoeic patients with palpable livers had higher pre- and post-prandial SCCA levels. Post-prandial SCCA levels failed to discriminate between control and CF groups however. Other serum tests of liver function, including the aspartate amino transferase, alkaline phosphatase, albumin, gamma globulin, and albumin : globulin ratio, failed to correlate with the SCCA. Changes in serum protein constituents correlated strongly with pulmonary dysfunction. The results suggest that elevation of fasting SCCA levels in CF patients is a more sensitive indicator of liver dysfunction than other tests and is a better discriminator than post-prandial SCCA levels between normal and abnormal liver function. The test is recommended for early detection of liver dysfunction in CF patients.

Adolescent↗
PubMed1976

Five- to seven-year course of pulmonary function in cystic fibrosis.

The pulmonary function records of 132 patients with cystic fibrosis followed for 5 to 7 years were reviewed. Changes in forced vital capacity, 1-sec forced expiratory volume, mean forced expiratory flow during the middle half of the forced vital capacity, and 1-sec forced expiratory volume as a percentage of forced vital capacity were examined. There was considerable variation in the rates of change, but the general pattern was consistent with a theory of exponential decline, mean forced expiratory flow during the middle half of the forced vital capacity showing the earliest and most dramatic changes. The pulmonary function of 33 patients (25 per cent) remained stable or improved throughout follow-up, possibly reflecting mild forms of lung disease or the efficacy of therapy. Twenty of these patients (15 per cent) maintained completely normal pulmonary function. The rate of decline in pulmonary function values, with progress of the disease, was steeper in the female patients.

Adolescent↗