PubMed Health⌕ Search

Biomedical subjects

D Cvorisćec

Publications and source records attributed to D Cvorisćec.

12 recordsLinked to original sources
PubMed1991

[Serum acute phase proteins for determining disease activity of ulcerative colitis and Crohn disease].

We studied the activity assessment of ulcerative colitis and Crohn's disease by 5 acute phase reactants: C-reactive protein (CRP), alpha 1-acid glycoprotein, alpha 1 antitrypsin, haptoglobin and fibrinogen. From a large register of patients with inflammatory bowel disease (IBD) we chose randomly 91 patients: 61 with ulcerative colitis and 30 with Crohn's disease. As a reference point in the disease activity assessment we used standard clinical indices. Statistical analysis was performed by non-parametric methods: the Kruskal-Wallis and Fisher's exact test. The disease activity assessment in patients with ulcerative colitis by the index according to Powell-Tuck indicated that the patients with active disease (N = 19) had significantly higher levels of all acute phase proteins mentioned above except fibrinogen (alpha less than 0.05 to 0.001) than patients in remission (N = 42). Analysis of the same data by Fisher's exact test indicated that there had been a probability for all the proteins measured to be higher than the normal values, particullary CRP (p less than 10(-8) and the other somewhat less. In patients with Crohn's disease, the disease activity assessment was performed by 2 indices. According to "The Crohn's Disease Activity Index" (CDAI), only alpha-1 acid glycoprotein and haptoglobin (alpha less than 0.05) were higher in patients with active disease (N = 4) than in patients with remission (N = 26).(ABSTRACT TRUNCATED AT 250 WORDS)

Acute-Phase Proteins↗
PubMed1991

[Quantitative evaluation of the immunoglobulin G, A and M in the human dental pulp].

The presence of immunoglobulins G, A and M was studied in human dental pulps using a quantitative method of radial immunodiffusion. Valid data on the amounts of IgG, IgA and IgM were obtained on the basis of measured concentrations of immunoglobulins in each pulp sample and their correlation with total protein concentrations. The results indicated IgG to be present in 100%, IgA in 15% and IgM in 8% of 13 pulp samples affected by chronic inflammation. The mean values of IgG, IgA and IgM thus determined were 84.3, 4.4 and 1.4 mg/g protein, respectively. In intact pulp tissue, however, no presence of immunoglobulins G, A and M could be detected using the same method as above. The results obtained suggested the possibility of local synthesis of immunoglobulins in chronically inflamed pulp tissue, indicated that nonspecific inflammatory reaction may have occurred concurrently with some specific immunologic reactions. The predominance of IgG pointed to immunologic reactions of early types II and III hypersensitivity.

Dental Pulp↗
PubMed1988

Tamm-Horsfall protein determination in Balkan endemic nephropathy.

Data on the excretion of Tamm-Horsfall protein (THP) in subjects living in an area of Balkan endemic nephropathy (BEN) are reported. The study subjects were divided into groups as follows: diseased, suspect, "at risk" and others, according to previously adopted criteria. The THP excretion in "at risk" subjects was found to be significantly higher as compared to control subjects. The difference between these two groups could not be registered by any other clinical or laboratory diagnostic methods. No difference in the excretion of THP was observed between the groups of others and control subjects. According to the results obtained, the excretion of THP may be considered a possibly useful additional diagnostic test for the detection of subjects with the latent, early subclinical phase of BEN. On the other hand, the data obtained shed some more light on the still obscure pathogenesis and natural history of BEN.

Adolescent↗
PubMed1988

Correlation between urinary excretion of Tamm-Horsfall protein and sodium chloride in endemic nephropathy.

Excretion of Tamm-Horsfall protein and of certain electrolytes was measured in subjects living in an area of endemic nephropathy, in subjects living in a control area, and in patients with other types of chronic renal disease. A significantly higher excretion of Tamm-Horsfall protein and of sodium chloride was observed in the diseased, suspect and subjects "at risk", as compared to the control subjects and patients suffering from other types of chronic renal disease. A positive linear correlation between urinary excretion of Tamm-Horsfall protein and of sodium chloride was found in all the study groups of subjects from the endemic and control areas as well as in patients with other renal diseases.

Balkan Nephropathy↗
PubMed1986

Relationship between tubular and Tamm-Horsfall proteinuria in Balkan endemic nephropathy.

Excretion of low molecular mass proteins derived from blood plasma and Tamm-Horsfall protein, a specific renal protein, was determined in the subjects from the area of Balkan endemic nephropathy. A significantly higher excretion of Tamm-Horsfall protein was observed in the subjects with tubular type of proteinuria compared to the subjects with glomerular selective type proteinuria and the subjects with physiological type proteinuria.

Adult↗
PubMed1985

Tamm-Horsfall protein in Balkan endemic nephropathy.

It is suggested that Tamm-Horsfall protein, a specific renal glycoprotein, may be involved in the pathogenesis of some renal diseases. In cadmium nephropathy and Fanconi syndrome (primary tubular diseases of the kidney) an increased excretion rate of Tamm-Horsfall protein has been observed. Balkan endemic nephropathy is a chronic tubulointerstitial disease of unknown etiology, most probably a primary disease of the kidney tubules with secondary reaction of the interstitial tissue. Investigation of Tamm-Horsfall proteinuria in Balkan endemic nephropathy has shown that subjects living in the area where this condition is prevalent have a significantly higher Tamm-Horsfall protein /creatinine ratio than those living in the control area where the condition has not been observed. Differences in this ratio among diseased, suspect and subjects "at risk" were not observed, despite differences in their glomerular filtration rates. But excretion of Tamm-Horsfall protein per litre of glomerular filtrate was significantly different among diseased, suspect and subjects "at risk" and significantly higher compared to control subjects. a relatively significant correlation was obtained between Tamm-Horsfall protein excretion rate and glomerular filtration rate as measured by creatinine clearance in both control and subjects living in the area of Balkan endemic nephropathy. Determination of Tamm-Horsfall protein in urine together with determination of proteinuria by electrophoresis on cellulose acetate membranes as a screening procedure, and by SDS -electrophoresis in polyacrylamide gell may be useful laboratory tests in detecting this nephropathy.

Adolescent↗
PubMedDate not supplied

[Value of C-reactive protein in the evaluation of activity in ulcerative colitis and Crohn's disease].

We studied a value of measuring the C-reactive protein (CRP) serum concentration in the assessment of ulcerative colitis and Crohn's disease activity. From a large register of patients with the inflammatory bowel disease (IBD), we have chosen randomly 91 patients: 61 with ulcerative colitis and 30 with Crohn's disease. As a reference point in the assessment of ulcerative colitis we have used the Powell-Tuck clinical index. Nineteen patients had an active disease, and 42 were in a remission. Patients with the active disease had significantly higher levels of the CRP then the patients in remission (chi 2 = 4.99; alpha less than 0.05). Serum CRP levels and the disease activity assessment by Powell-Tuck index were in a positive correlation, according to the Fisher's exact test (p less than 10(-8)). In the group of 30 patients with Crohn's disease, the disease activity was assessed by CDAI ("The Crohn's Disease Activity Index") and by van Hees index. According to CDAI, 26 patients were in a remission, and only 4 had an active disease. According to van Hees index, there was no patient in a complete remission, 17 patients had a partial remission and 13 had an active disease. Patients with the active disease had significantly higher CRP levels then the patients in remission, according to van Hees index (chi 2 = 7.863; alpha less than 0.01), but not according to CDAI (not significant). Meanwhile, the Fisher's exact test suggested a high positive correlation between the disease activity assessment with both indexes, either CDAI or van Hees, and the CRP serum values (alpha less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

C-Reactive Protein↗