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Biomedical subjects

D D Datubo-Brown

Publications and source records attributed to D D Datubo-Brown.

18 recordsLinked to original sources
PubMed1994

Tissue-expanded visor flap in burn surgery.

Severe postburn scarring of the lower face in the adult male may cause loss of mustache and beard in addition to other complications. The resulting unacceptable boyish appearance in 3 such patients was treated with tissue-expanded visor flap reconstruction. Complications, which were few, minor, and temporary, included moderate postoperative hematoma, hair-bearing skin loss in the region of the sideburns, and hair growth in an unwanted direction. The flap is safe to perform, with adequate blood supply, and achieved the goal of the operation, which is the restoration of a masculine appearance. The major advantage of this procedure is that the donor site morbidity and alopecia associated with the classic visor flap is virtually eliminated.

Adult↗
PubMed1991

The treatment of donor sites with cultured epithelial grafts.

In a significant number of elderly patients, the healing of split skin donor sites can be delayed. The cultured allogenic epithelial graft (CAG) has been reported to heal leg ulcers. The mechanism of action may be to improve the healing environment and thus stimulate the host skin cells. A clinical trial was undertaken to compare the healing rate of the donor sites of elderly patients using CAGs and two commercially available dressings. Compared to Jelonet, CAGs (p = 0.008) and OpSite (p = 0.013) significantly reduced the number of patients with delayed healing. There was no significant difference between CAGs and the occlusive dressing, OpSite.

Aged↗
PubMed1991

Primary malignant skin tumors in Nigerians.

Skin cancers, although uncommon, do occur in black Africans. Available literature on this subject from black African populations is scant, suggesting diminished interest. Eighteen cases of malignant skin tumors seen at the University of Port Harcourt Teaching Hospital over 3 years (1984 to 1987) were analyzed for diagnoses, site of tumors, sex, and age. Seven patients (39%) had malignant melanomas affecting only the soles of the feet, while the same number had squamous cell carcinomas widely distributed in various parts of the body. Basal cell carcinomas were found in four (22%) patients with face lesions. Only three albinos were in the series, and all three had squamous cell carcinomas. Melanin protection against sun-induced skin cancers gives a false sense of well-being. The need for renewed interest of the subject is emphasized.

Adult↗
PubMed1990

Keloids: a review of the literature.

A review of the literature on keloids, a complex and poorly understood subject, is presented. Keloid is a disease principally of the human dermis, and occasionally the cornea, appearing as thick scar tissue invading normal skin or cornea and produced by the deposition of excessive amounts of collagen over prolonged periods. The African negro is particularly susceptible. Available methods of treatment include surgical excision, external superficial radiotherapy, interstitial irradiation, intralesional steroid injections, cryotherapy, ultrasound, systemic chemotherapy, zinc tape strapping, pressure and silicone gel. Any of these could be used alone or in combination with other forms of treatment. The lesions are notoriously recurrent and their management frustrating. The risk of late tumour induction following radiotherapy and systemic complications of depot steroids are underlined. There is still the need for a better understanding of the behaviour of keloids. This should form the biological basis on which to plan more effective prevention and treatment, with minimal complications.

Culture Techniques↗
PubMed1990

Inhibition of human fibroblast growth in vitro by a snake oil.

The inhibitory effects of boa constrictor fat (BCF) oil on the growth kinetics of keloid and normal dermal fibroblasts were tested in fibroblasts cultures. BCF significantly (p less than 0.0001) inhibited the in vitro growth of both keloid and normal dermal fibroblasts. Although the active ingredient(s) in this snake oil is not yet determined, it is postulated that fatty acids which are the main constituents of the oil may in part account for this observed in vitro effect.

Animals↗
PubMed1990

Pattern of cleft lip and palate deformities in Rivers State of Nigeria.

The pattern of congenital cleft lip and/or palate deformities in the Rivers State of Nigeria is being presented. Thirty nine patients seen over four years were retrospectively studied. Similar to the other published African series but unlike the Caucasian series, isolated cleft of the lip was the predominant lesion seen in this study (54%). In contrast, however, to the same African Series the isolated cleft of the palate was only seen in girls (15%). The unusual cleft deformities are highlighted while the significance of associated congenital malformations is examined.

Adolescent↗
PubMed1990

Benign breast lesions in Nigerian women in Rivers State.

A review of histologically confirmed benign breast lesions in 155 Nigerian women seen over a 4 year period (1984-1987) at the University of Port Harcourt Teaching Hospital showed that 79 (51%) had fibroadenoma, 43 (27.7%) fibrocystic disease, 23 (14.8%)--inflammatory disorders and 10 (6.5%)--a miscellaneous group of lesions. Thirteen patients had multiple fibroadenomas, while four had successive or recurrent tumours. Out of 33 patients, 21 had fibroadenoma for at least 1 year. The positive correlation between the average tumour size and duration of symptoms suggests that delay in seeking medical attention contributes to the large size of fibroadenomas often seen in sub-Saharan Africa. The possibility that high reproductive rate may be contributory to the relatively low frequency of fibrocystic disease in this series is discussed.

Adolescent↗
PubMed1989

Contact burns in children.

Forty-seven children under the age of 5 years admitted for contact burns into the Burns Unit of the Birmingham Accident Hospital during the period 1981-88 were reviewed. Contact burns formed only 3.93 per cent of all the thermal injuries seen in this age group for the same period. Most of the children were between 1 and 2 years of age and the hands and face were more frequently burned. The hot electric iron was the commonest cause of burns in the study. Although the sizes of the burns were generally small, the potential scarring and disability were recognized and this influenced the management. The prevention of contact burns from hot electric irons has been discussed and the need to look out for non-accidental injuries emphasized.

Age Factors↗
PubMed1989

Burn injuries in Port Harcourt, Nigeria.

The pattern of burn injuries in Port Harcourt, Nigeria is presented for the first time. Ninety-two patients were studied and 43 (46.74 per cent) of them were children in the 0-5 years age range. Thirty-seven of the children in this group suffered from scalds and six from flame burns. Petrol fire was the commonest cause of flame burns. The overall mortality was 26.09 per cent and the majority of deaths occurred in burns covering over 50 per cent of the total body surface area. Improved parental supervision of children, in particular toddlers, a more reliable public power supply system, a ban on carrying petrol in open containers in the streets and public enlightenment campaigns are advocated by the authors as preventive measures.

Accidents↗
PubMed1989

Fatal haematemesis in childhood associated with aorto-oesophageal fistula.

A case of fatal haematemesis associated with a non-traumatic, non-tuberculous aorto-oesophageal fistula in a 9-year-old Nigerian boy is presented. Autopsy revealed two inflamed and ulcerated mild-oesophageal pulsion diverticula, one of which had eroded into the right pleura as a sinus track. The second diverticulum had perforated and caused mediastinitis and eventually aorto-oesophageal fistula which led to the fatal haematemesis. A mild chest injury is seen as a precipitating factor of the haematemesis and not the initiator of the pathology.

Aortic Diseases↗
PubMed1989

Deliberate burns in Nigerians.

Eleven cases of deliberate burns in Nigerians were studied. Three major reasons for burning were recognized. Ignorance was identified as a factor in the aetiology of some of these avoidable burns. Primary prevention of the burns and the secondary prevention of their complications are outlined. The management of the patients is discussed.

Accidents↗
PubMed1989

Clinical and pathological features of breast cancers in Rivers State, Nigeria.

In this study, the clinico-pathological features of breast cancers seen in Rivers State of Nigeria were retrospectively analysed. Nine out of 67 patients (13%) were younger than 30 years of age. Only 13% of 46 patients presented within one month of the onset of symptoms. The mean duration of symptoms varied from 3.7 months in patients under 30 years of age to 13.3 months in those in the 50-59 years age range. Most patients, 40 out of 51, presented with axillary lymph node metastases, the incidence of which varied directly with both the duration of symptoms and age. It is suggested that the rise in the incidence of axillary lymph node metastasis with age is determined by increase in the duration of symptoms. These results highlight the need to intensify cancer education in the population. The presenting complaints and the distribution of the various histological types did not differ from other reports.

Adult↗
PubMed1989

Congenital cleft deformities in Rivers state of Nigeria: is there any association with environmental pollution?

Thirty-nine children with congenital cleft deformities seen at the University of Port Harcourt Teaching Hospital over a four-year period (1984-87) were studied. The majority (69%) of the children came from PHALGA, OTELGA and ALGA, the areas of the state with a high concentration of oil wells, gas flares and a petroleum refinery. There is yet no proof that there is a cause and effect relationship between the deformities and the industrial pollution but attention has been drawn to the association, which may be real or apparent. Further prospective studies are indicated. Apart from the possible role of environmental pollution, other epidemiological factors discussed include parental age, socioeconomic class of the families and the significance of the absence of positive family history of cleft deformities in all the cases studied.

Adolescent↗
PubMed1989

Craniofacial clefts in a black African population.

Seven black children with craniofacial anomalies are reported. Holoprosencephaly and hemifacial microsomia featured prominently among the cases presented. These cases represented a large percentage of all cleft cases reported in the region served by the Port Harcourt Teaching Hospital (UPTH). The social, genetic, and surgical implications are discussed.

Abnormalities, Multiple↗
PubMed1988

Human bites of the face with tissue losses.

Human bites of the face are common in Port Harcourt, Nigeria. Twenty-four such patients with tissue losses seen over a period of two years (1983-1985) at the University of Port Harcourt Teaching Hospital were studied. Women in their third decade of life seem to be most at risk; the lips and ears are most frequently bitten. Primary repair and administration of systemic antibiotics within 24 hours of the injury gave good results. Secondary reconstructive repair is advised if the patient is seen 24 hours after the time of the bite. The reconstruction of the whole pinna has been difficult in our experience and external prosthetic replacement is advocated in such cases as an alternative to microsurgical replantation. Free use of certain facial flaps has been avoided for fear of creating keloid scars because we are dealing with a purely black population.

Adult↗
PubMedDate not supplied

Bacteriology of wound infections in the surgical wards of a teaching hospital.

Seventy nine swab specimens obtained from various categories of wounds suspected to be infected on clinical grounds were cultured for the presence of aerobic bacteria and their pattern of antibiotic sensitivity determined. The twin genera of Staphylococcus and Pseudomonas contributed equally to burn infections while Staphylococcus species were clearly predominant in surgical wound infections. Pseudomonas species were more common in ulcers which were also characterised by a higher incidence of Escherichia coli and multiple microbial infections. The isolates were generally very resistant to the test antibiotics and showed very little sensitivity to commonly used antibiotics such as compound sulphonamides, ampicillin, cotrimoxazole and tetracycline. However, in vitro sensitivity to colistin and gentamycin was considered moderate. The need for judicious choice of antibiotics in the treatment of bacterial infections is stressed.

Cross Infection↗
PubMedDate not supplied

Pattern of surgical acute abdomen in the University of Port Harcourt Teaching Hospital.

This paper presents a retrospective study on 279 cases of surgical acute abdomen seen and treated at the University of Port Harcourt Teaching Hospital over a period of about 2 1/2 years, September 1983-February 1986. The majority of the patients were in the second and third decades of life. Acute appendicitis and obstructed hernias were the commonest causes of surgical acute abdomen, while abdominal pain and vomiting were the commonest symptoms. Only two patients in the series had acute pancreatitis. The overall mortality was 13.3%.

Abdomen, Acute↗