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Biomedical subjects

D D Mar

Publications and source records attributed to D D Mar.

At least 19 recordsLinked to original sources
PubMed1992

SCOUT: information retrieval from full-text medical literature.

SCOUT is an expert system designed to aid the practicing physician in searching a full-text database of biomedical literature for information in the domain of oncology. In the clinical setting, an information-retrieval system needs to provide only a few relevant documents that address a patient-specific query. SCOUT models the expertise of an oncologist and an information specialist in a probabilistic inference system; it applies expert heuristics both in selecting the best source of information for a particular question and in developing an effective, source-specific search statement that retrieves only a minimal number of pertinent documents.

Expert Systems↗
PubMed1981

Bronchodilatory effect of subcutaneous epinephrine in acute asthma.

Thirty-two adult patients presenting to the emergency department for treatment of acute asthmatic attacks refractory to home medications were studied. Each patient was randomly given a subcutaneous injections of 0.1 mg, 0.3 mg, or 0.5 mg epinephrine in a double-blind fashion. Bronchondilatation, as measured by peak expiratory flow rate (PEFR), was measured before and at 10, 20, and 40 minutes after injection. Bronchondilatation occurred with all dosages of epinephrine. No significant difference in PEFR was demonstrated among the three doses of epinephrine. Mean PEFR at each time differed significantly from the means of the other three values, with a steady increase over time (0.01 less than p less than 0.05). Repeating subcutaneous doses of epinephrine before maximal bronchondilatation is obtained may be irrational and potentially dangerous.

Adult↗
PubMed1981

Identifying the acutely ill patient with asthma.

We studied 77 patients suffering acute asthma to identify those who needed hospitalization. Patients randomly received various doses of subcutaneous epinephrine. Peak expiratory flow rate (PEFR) was measured initially and at ten and 20 minutes after epinephrine administration. If adequate response was not noted from three doses of epinephrine, aminophylline and later hydrocortisone were given. Patients were admitted to the hospital if they did not improve or required emergency room treatment for four hours. Thirty-five percent (13/37) of the patients with an initial PEFR of less than or equal to 100 liters/min required hospital admission, whereas only 8% (3/40) with an initial PEFR of greater than 100 liters/min required hospitalization (P less than .01). Analysis of patients in the group at high risk also revealed significant differences between hospitalized and nonhospitalized patients in PEFR. Asthmatics with significant airway obstruction (initial PEFR, less than or equal to 100 liters/min) who do not show prompt improvement after optimal epinephrine therapy should be closely observed and considered candidates for hospital admission.

Acute Disease↗
PubMed1981

Antacid therapy.

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Antacids↗