Biomedical subjects
Publications and source records attributed to D D Sawaikar.
A new germacranolide has been isolated from the aerial parts of Artemisia pallens and the structure was established as 4,5 beta-epoxy-10 beta-hydroxy-1-en-3-one-trans-germacran-6 alpha,12-olide (1) by comparison with its 10 alpha-epimer isolated from the same plant.
Three new eudesmanoids have been isolated from Sphaeranthus indicus and their structures were established as 11alpha,13-dihydro-3alpha,7alpha-dihydroxy-4,5-epoxy-6beta,7-eudesmanolide, 11alpha,13-dihydro-7alpha-acetoxy-3beta-hydroxy-6beta,7-eudesm-4-enolide and 3-keto-beta-eudesmol by comparison of spectral data with those of other 7alpha-hydroxyeudesmanolides.
The increasing incidence of contact dermatitis due to the wild growth of the weed Partheium hysterophorus Linn. in many parts of India has prompted chemical analysis coupled with clinical testing to isolate the offending agent. Results are present to show that parthenin, a sesquiterpene lactone, is the major antigen which produces contact dermatitis in sensitive human beings.