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Biomedical subjects

D D'Adda

Publications and source records attributed to D D'Adda.

5 recordsLinked to original sources
PubMed1996

The macrophagic activity of patients affected by pneumonia or chronic obstructive pulmonary disease.

The function of alveolar macrophages (AMS) in patients with pneumonia (n = 7) (Group A) and chronic obstructive pulmonary disease (COPD) (n = 11) (Group B) was investigated by evaluating the rate of phagocytosis and of the intracellular killing. A control group of healthy subjects (n = 8) was also included. Phagocytosis frequency (PHF), phagocytosis index (PHI) and intracellular killing towards Candida albicans were then evaluated. PHF and PHI were found to be significantly (p < 0.05) lower in Group B patients than in the control group, while intracellular killing showed a behaviour similar to controls. PHF and PHI values observed in the patients of Group A and in the control group did not show any significant difference; the intracellular killing rate proved on the contrary to be significantly (p < 0.05) lower than that observed in the controls.

Adult↗
PubMed1993

Cisplatin plus epirubicin and etoposide followed by irradiation plus lonidamine in stage III nonsmall cell lung cancer.

Forty-seven patients with stage III nonsmall cell lung cancer (NSCLC) were treated with the sequential administration of combination chemotherapy consisting of cisplatin, epirubicin and etoposide and of irradiation plus lonidamine. The response rate was 49% after chemotherapy with an improvement of 14% after radiation therapy and lonidamine. The median survival was around 15 months for responders and 9 months for nonresponders. Toxicity was moderate and acceptable. It is concluded that this schedule is active in the treatment of NSCLC.

Adenocarcinoma↗
PubMed1981

Increase in lipolysis and decrease in plasma-heparin lipoprotein lipase activity and alpha 1 lipoprotein level after aminophylline in man.

Intravenous aminophylline 0.48 g produced a sharp increase in plasma free fatty acids. After three days of treatment with aminophylline 0.96 g/day i.v., plasma post-heparin lipoprotein lipase was significantly reduced, and post-heparin hepatic triglyceridase remained unchanged. alpha 1 lipoprotein was reduced by treatment, in parallel with lipoprotein lipase, while other lipoprotein fractions, serum cholesterol and triglycerides were unaffected.

Adult↗