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D Daud

Publications and source records attributed to D Daud.

8 recordsLinked to original sources
PubMed2001

The hemoglobin O mutation in Indonesia: distribution and phenotypic expression.

We have investigated hemoglobin O Indonesia (HbOIna) in related ethnic populations of the Indonesian archipelago: 1725 individuals of the five ethnic populations of South Sulawesi (Bugis, Toraja, Makassar, Mandar, and Kajang) and 959 individuals of the neighboring islands, who were divided into five phylogenetic groups: (a) Batak; (b) Malay from Padang, Pakanbaru, and Palembang in the island of Sumatra; (c) Javanese-related populations (Java, Tengger, and Bali) from the islands of Java and Bali; (d) populations of the Lesser Sunda Islands of Lombok, Sumba, and Sumbawa; and (e) the Papuan-languagespeaking population of Alor Island. Nineteen individuals heterozygous for HbO(Ina) were identified from the Bugis, Toraja, Makassar, and Kajang ethnic populations, but none from the other populations. In all cases, the underlying mutation was found to be in codon 116 (GAG to AAG) of the alpha1-globin gene, resulting in the Glull6Lys amino acid change. The level of HbO in the 17 individuals plus 12 additional family members carrying the mutation was found to be 11.6 +/- 1.0%, significantly lower than the expected 17%-22%, indicating the instability of HbO.

Amino Acid Substitution↗
PubMed2001

Calcium intake and bone mass development among Israeli adolescent girls.

OBJECTIVE: To determine the possible relationship between food and life style habits and bone health in adolescent Israeli females. METHODS: 2,000 adolescent Israeli Jewish and Arab high-school girls (mean age 14.5) completed a semi-quantitative food frequency questionnaire and a personal history questionnaire. 27 food components were calculated for each subject. Bone mineral content and density were determined for 112 subjects with calcium intake below 800 mg/day. RESULTS: Average calcium intake was found to be 1,260 mg/day, but 20% of all girls had a calcium intake below 800 mg/day. All low-energy diets were very low in calcium, as mean calcium intake per 1,000 calories was 411 128 grams. A large percentage of diets with less than 800 mg calcium were also deficient in phosphorus (95.2%), magnesium (84.8%). iron (90.5%) and zinc (100%). Due to differences in food sources. Jewish girls had more phosphorus in their diet, but less magnesium and iron compared to Arab girls. Calcium and zinc deficiencies in Jewish and Arab diets were similar. A negative correlation was found between body mass index (BMI) and age at menarche for all girls in the study. Bone mineral density (BMD) measured for girls with calcium intake below 800 mg/day distributed normally around the average when compared to age matched controls despite their low calcium intake. There was a strong positive correlation between BMD and bone mineral content (BMC) at all sites and body weights. CONCLUSIONS: Low calcium intake, other nutritional deficiencies and delayed menarche due to low-energy diet in the growing period and in adolescence may prevent the formation of healthy bones. There is no evidence of lower bone mass among the low calcium intake group in the study population at this stage. It remains to be documented if the window of opportunity for optimal bone accretion for this group will be missed in the future. possibly leading to increased risk of osteoporosis.

Adolescent↗
PubMed1999

Phenotypic variability of Filipino beta(o)-thalassemia/HbE patients in Indonesia.

Three Indonesian patients with identical genotypes, each compound heterozygotes for Filipino beta(o)-thalassemia/HbE, expressed different clinical severities. One patient has mild disease and is transfusion independent, while the other two are severely affected and transfusion dependent. The size of the Filipino beta(o)-globin gene deletion was confirmed to be 45 kb, resolving conflicting values given in the literature. Neither ameliorating genetic factors such as alpha-globin gene deletions or the XmnI restriction site polymorphism at position -158 upstream of the (G)gamma-globin gene, nor differences in beta-globin gene haplotype, explain the phenotypic variation. These observations have implications for the development of antenatal diagnosis in Indonesia, as at present it is not possible to give an accurate prediction of severity of phenotype for this common genotype.

Child↗
PubMedDate not supplied

Plasma concentrations of urea and creatinine in primary school children in Ujung Pandang.

A study of plasma concentrations of urea creatinine in 202 primary school children aged between 6 to 15 years was carried out in Ujung Pandang from November 1, 1988 through February 28, 1989. Sampling was done using multi-stage random sampling method. Plasma urea concentrations were not affected by sex, age and nutritional status. Normal distribution of plasma urea concentrations in P2.5 and P97.5 were 8.13 mg/dl and 24.09 mg/dl respectively (95% confidence level). There was no difference of creatinine concentration between the two sexes. The overall mean creatinine concentrations was significantly higher in the well-nourished group (0.73 +/- 0.081) mg/dl) as compared to PEM group (0.63 +/- 0.066 mg/dl). This study revealed a correlation between age and plasma creatinine concentrations in the well-nourished (r = 0.46, p less than 0.01) as well as in PEM (r = 0.37, p less than 0.01) group. Hence, normal distribution of plasma creatinine concentrations should be base on values in each age group. This study showed no correlation between plasma urea and creatinine concentrations.

Adolescent↗
PubMedDate not supplied

Bull-neck, electrocardiographic changes and creatine phosphokinase blood levels in patients with diphtheria.

All paediatric patients with the diagnosis of diphtheria who were seen at the Department of Child Health Ujung Pandang General Hospital from October 1987 to October 1989 were evaluated for bull-neck, ECG patterns and serum creatine phosphokinase (CPK) values. Their ages ranged from 1 year and 2 months to 13 years with a mean of 6.54 +/- 3.09 years. Males and females were affected in a ratio of 1:1. Of 39 patients included in the trial, 28 were classified as having normal ECG and 11 as having abnormal ECG on admission. During hospitalization, 56.4% of cases showed ECG changes. All patients had raised serum CPK levels on admission. This increase was 14.6 times the normal level in cases with abnormal ECG and only 3.0 times in those with normal ECG (p < 0.01). The highest levels of serum CPK were noted in the first week, then returned to normal in the second week and decreased further in the third week. It became also evident that patients who developed abnormal ECG later on, had already demonstrated an increased serum CPK level of 5.2 times the normal levels on admission. Bull-neck appeared in 19 out of the 39 patients. Patients with bull-neck differed very significantly (p < 0.001) from those without bull-neck in either the frequency of the occurrence of abnormal ECG patterns or the mean CPK serum levels.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMedDate not supplied

Capillary microhematocrit measurement as a screening test for anemia in children.

The spectrophotometric measurement of hemoglobin performed with a well standardized instrument using venous blood is widely accepted as a reference standard for anemia. In developed countries automated electronic counters are used instead. However, this method of determining anemia is not practical for screening in developing countries as it requires special skill or expensive equipment to obtain the specimen or to perform the test. The primary objective of this study was to determine the feasibility of using capillary microhematocrit measurement as a screening test for anemia. The 104 patients examined ranged in age from 6 months to 6 years; 65 were males and 36 females. Sixty one of the 104 cases (58.7%) were below 2 years of age and the other 43 cases (41.5%) were older than 2 years. Hemoglobin values ranged from 2.7-13.5 g/dl and capillary microhematocrit ranged from 9-41%. Analysis of the result showed a significant correlation between the capillary microhematocrit values and the capillary hemoglobin values (r = 0.99 and p less than 0.001). The sensitivity of the microhematocrit method for detecting anemia was 91.11% and the specificity was 89.83%. The predictive value for a normal (negative) microhematocrit was 92.98% and the predictive value for a low (positive) microhematocrit was 87.23%. We conclude from this study that the capillary microhematocrit measurement method can be appropriately used as a screening test for anemia.

Anemia↗