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D DePalma

Publications and source records attributed to D DePalma.

4 recordsLinked to original sources
PubMed1993

The dopamine DA-1 receptor agonist fenoldopam enhances amino-acid-induced hyperemia in dogs.

The effect of the dopamine DA-1 receptor agonist fenoldopam on amino-acid-induced glomerular hyperemia and hyperfiltration was evaluated in conscious chronically instrumented dogs. Infusion of either amino acids (L-alanine, 4.1 mg/kg.min; L-proline, 3.2 mg/kg.min; L-serine, 2.9 mg/kg.min) or fenoldopam (0.05 micrograms/kg.min) alone resulted in significant (p < 0.05) increases in renal plasma flow of 85 +/- 41 and 53 +/- 24%, respectively. In dogs infused with both amino acids and fenoldopam, there was a dramatic (143 +/- 27%) increase in renal plasma flow (p < 0.01). This response was significantly greater than either treatment alone. The glomerular filtration rate did not change significantly when fenoldopam was infused; however, it increased to a similar degree when dogs were infused with either amino acids or a combination of fenoldopam and amino acids. The data suggest that fenoldopam either acts synergistically with amino acids to increase renal blood flow or perhaps magnifies the renal functional reserve.

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-ben↗
PubMed1976

Cardiac manifestations of ochronosis.

A 68-year-old woman with ochronosis was admitted with congestive heart failure. A typical ejection murmur of aortic stenosis was ausculated and was documented on a phonocardiogram. The patient subsequently died, and at autopsy extensive deposition of ochronotic pigment was found on the aortic valve. This valve had no other anatomic abnormalities. Thus ochronosis should be considered in the differential diagnosis of aortic stenosis.

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