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D Debanne

Publications and source records attributed to D Debanne.

25 records · Page 2Linked to original sources
PubMed1994

Asynchronous pre- and postsynaptic activity induces associative long-term depression in area CA1 of the rat hippocampus in vitro.

Associative long-term depression (LTD) was induced in hippocampal slice cultures with repeated low-frequency (0.3 Hz) stimulation of the Schaffer collateral pathway, only when such stimuli were preceded by intracellular injection of brief depolarizing current pulses in the postsynaptic CA1 pyramidal cell. The decrease in excitatory postsynaptic potential amplitude lasted > 30 min, could be reversed by induction of potentiation, could be induced at previously potentiated inputs, was input-specific, and did not require activation or potentiation of other inputs. The magnitude of the depression depended upon the time interval between depolarization and stimulation and upon the duration of the depolarization pulse. LTD was not observed in neurons impaled with electrodes containing a Ca2+ chelator. LTD could not be induced in the presence of an N-methyl-D-aspartate receptor antagonist, suggesting that voltage-dependent Ca2+ influx is necessary but not sufficient for LTD induction. We conclude that associative LTD results when synaptic activity follows postsynaptic depolarization within a circumscribed time window.

2-Amino-5-phosphonovalerate↗
PubMed1994

Role of excitatory amino acid and GABAB receptors in the generation of epileptiform activity in disinhibited hippocampal slice cultures.

Selective excitatory amino acid- and GABAB-receptor antagonists were used to examine the role these receptors play in epileptiform burst discharge elicited by blocking GABAA receptor-mediated inhibition in hippocampal slice cultures of the rat. Application of bicuculline caused a single ictal burst followed by interictal bursting. The N-methyl-D-aspartate receptor antagonist, D-2-amino-5-phosphonovalerate, reduced the depolarizing envelope underlying interictal discharge, and accentuated the appearance of concomitant slow oscillatory potentials, which occurred synchronously in all CA3 cells. The non-N-methyl-D-aspartate receptor antagonists, 6-nitro-7sulphamoyl-benzo(F) quinoxaline and 6-cyano-7-nitro-quinoxaline-2,3-dione, blocked interictal bursting at high concentrations, and low concentrations of 6-cyano-7-nitro-quinoxaline-2,3-dione selectively eliminated the slow oscillations in an all-or-none manner, leaving the depolarizing envelope. No effects of either metabotropic glutamate receptor antagonists or of dihydropyridine Ca2+ channel agonists or antagonists on evoked interictal discharge were observed. 6-Cyano-7-nitro-quinoxaline-2,3-dione-resistant interictal-like discharge could be obtained in the presence of bicuculline when the external Mg2+ concentration was reduced from 1.5-0.5 mM. The GABAB receptor antagonist CGP 35348 prolonged individual evoked interictal bursts, and caused the appearance of spontaneous ictal-like discharges. The implications of these results are discussed with regard to the mechanisms of epileptogenesis and to potential therapeutic intervention.

6-Cyano-7-nitroquinoxaline-2,3-dione↗
PubMed1992

Synaptic origin of rhythmic visually evoked activity in kitten area 17 neurones.

Rhythmic patterns in neuronal activity in response to moving stimuli were observed in 28% of cells recorded extracellularly or intracellularly in area 17 of 4-16 week old anaesthetized and paralysed kittens. In both recording modes, oscillation frequencies ranged between 7 and 71 Hz, and were confined for 88% of cells in the 7-20 Hz band of the spectrum. A comparative study of firing autocorrelograms) and subthreshold activity (autocorrelation functions) indicates that the regularity of discharge stemmed from visually evoked oscillations of membrane potential at the same frequency. These oscillations are shown to result from extrinsic excitatory activity, since their amplitude, but not their frequency, depends on the resting membrane potential. The dependency on stimulus configuration supports the hypothesis that oscillations in neuronal output are dictated by periodic activity in afferent circuits selectively recruited by different attributes of the visual input which are not exclusively processed at the cortical level.

Animals↗
PubMedDate not supplied

Gating of action potential propagation by an axonal A-like potassium conductance in the hippocampus: a new type of non-synaptic plasticity.

Synaptic plasticity is usually considered as the main form of activity-dependent functional plasticity in the mammalian brain. Short- and long-term regulation of synaptic transmission have been shown in various types of excitatory synapses including cortical and hippocampal synapses. In this review, we discuss a novel form of non-synaptic plasticity that involves voltage-gated K+ conductances in CA3 pyramidal cell axons. With experimental and theoretical arguments, we show that axons cannot only be considered as a simple structure that transmit reliably the action potential (AP) from the cell body to the nerve terminals. The axon is also able to express conduction failures in specific axonal pathways. We discuss possible physiological conditions in which these axonal plasticity may occur and its incidence on hippocampal network properties.

Action Potentials↗
PubMedDate not supplied

The role of dendritic filtering in associative long-term synaptic plasticity.

Several forms of synaptic plasticity in the neocortex and hippocampus depend on the temporal coincidence of presynaptic activity and postsynaptic trains of action potentials (APs). This requirement is consistent with the Hebbian, or correlational, type of cellular learning rule used in many studies of associative synaptic plasticity. Recent experimental evidence suggests that APs initiated in the axosomatic area are actively back-propagated to the dendritic arborization of neocortical and pyramidal cells. High-frequency trains of postsynaptic APs that are used as conditioning stimuli for the induction of Hebbian-like plasticity in both neocortical and hippocampal pyramidal cells display attenuation of the dendritic AP amplitude during the train. This attenuation has been shown to be modulated by neurotransmitters and by electrical activity. We suggest here that both spike train attenuation in the dendrite and its modulation by neurotransmitters and electrical activity may have important functional consequences on the magnitude and/or the sign of the synaptic plasticity induced by a Hebbian pairing procedure.

Animals↗
PubMedDate not supplied

Associative synaptic plasticity in hippocampus and visual cortex: cellular mechanisms and functional implications.

Synchronous pre- and postsynaptic neuronal activity results in long-term potentiation (LTP) of excitatory synaptic transmission in the hippocampus and the neocortex. Induction of this form of potentiation requires calcium influx mediated by NMDA receptors. Experimental evidence is reviewed for induction of long-term depression (LTD) of synaptic transmission in the hippocampus in vitro and neocortical neurons in vivo, when the discharge of the postsynaptic neuron is temporally decorrelated from the presynaptic stimulation. Homosynaptic LTD induced by low frequency tetani in the hippocampus in vitro requires NMDA receptor activation and a moderate calcium influx. The role of postsynaptic calcium as a key parameter in the encoding of temporal contiguity of neural activity and its possible implications in the formation of engrams during specific learning tasks are discussed.

Animals↗