Biomedical subjects

D Deffond

Publications and source records attributed to D Deffond.

21 records · Page 2Linked to original sources

PubMed1985

A photoacoustic investigation of the influence of some constituents of the stratum corneum on ultraviolet absorption.

Photoacoustic spectroscopy (PAS) was used to evaluate light absorption by solid samples. Application of this technique to the human stratum corneum (SC) was used to investigate the influence of some constituents of SC (water, lipids, hydrophilic substances) on ultraviolet (UV) absorption by this tissue. The results showed that the water content of SC modified the PAS signal obtained. For example, there was a fall of over 20% in the UV absorption coefficient when the SC water-content rose from 0 to 30%. Epidermal lipids were not shown to have any direct effect on UV absorption by SC. However, indirectly they do seem to have protected some of the hydrophilic substances from water extraction. After removal of these hydrophilic substances, the UV absorption from SC was greatly decreased. Results indicated that these hydrophilic substances were protected in situ by polar lipids enmeshed within the structure of SC.

Amino Acids↗

PubMedDate not supplied

[During the treatment or after... drug-induced convulsive accidents. Apropos of 70 cases].

During a five year period (1988-1992) 70 cases of seizures were collected by the Adverse Drug Reaction Monitoring Center of Clermont-Ferrand (3.58% of total collected cases). 31 cases (22 M and 9 F) occurred after a drug withdrawal. Benzodiazepines--either alone or in association--were the most often involved. Mean age was 48.8 +/- 2.6 years in this group and additional factors (alcohol abuse and/or association of drugs that lower the seizure threshold) were associated in 26 cases. 39 cases (14 M and 25 F) occurred on the course of various treatments. The most frequently involved drugs were neuropsychiatric, antiinfectious (especially beta-lactam antibiotics, fluorquinolones and isoniazid) and theophylline. Mean age was 56.5 +/- 3.8 years and additional different factors (high dosages, antecedents of epilepsy, underlying diseases) were present in 22 observations.

Adverse Drug Reaction Reporting Systems↗

PubMedDate not supplied

[Pyridoxine neuropathies. Review of the literature].

Daily needs of vitamin B6 are very low (2 mg per day) and widely covered by normal feeding. Pyridoxine deficiencies are exceptional (congenital metabolic abnormalities, drug or toxic-induced perturbations). First described in animal models, human cases of neuropathy had been encountered in the "megavitamin"-syndrome. They are confirmed by rare case-reports of very high doses given in toxic indication. Sensory peripheral neuropathies can also occur with lower doses taken over a long period of time.

Adult↗