Acute hepatic coma treated by cross-circulation with a baboon and by repeated exchange transfusions.
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Acute Disease↗
Biomedical subjects
D Dent
Publications and source records attributed to D Dent.
Inhibition of rotavirus infection in vitro and in vivo by a synthetic peptide from VP4.
A synthetic peptide corresponding to bovine rotavirus C486 (BRV) VP4 amino acid sequence 232-255 (VP4-peptide) was studied with the objective of defining the origin of the protective immune response reported previously by Ijaz et al. (J. Virol. 1991, 65, 3106-3113). Pretreatment of MA-104 cells with the VP4-peptide before infection with rotavirus prevented both the attachment of 35S-labelled virus and plaque formation in vitro. In vivo studies using a murine rotavirus model demonstrated that intragastric administration of VP4-peptide protected subjects from challenge with virulent rotavirus. These results clearly indicate the importance of this epitope in virus-cell interactions and their potential as a rotavirus vaccine candidate.
Amino Acid Sequence↗