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D Deppermann

Publications and source records attributed to D Deppermann.

17 recordsLinked to original sources
PubMed1992

Apolipoprotein E phenotypes and hyperlipidemia in patients under maintenance hemodialysis.

Apolipoprotein E phenotypes and gene frequencies were determined in 560 patients receiving long-term hemodialysis. In addition, fasting plasma lipid- and apolipoprotein-concentrations were evaluated in 245 of these individuals. The distribution of the three major apolipoprotein E alleles (epsilon 4, epsilon 3, and epsilon 2) and that of the six common apolipoprotein E phenotypes (E4/4, E3/3, E2/2, E4/2, E4/3, and E3/2) in the dialysis group was nearly identical to that of healthy controls. Patients with the apolipoprotein E phenotypes E2/2, E4/4 and E4/3 (comprising 24% of the whole group) had higher mean plasma cholesterol- and triglyceride-concentrations than those with the apolipoprotein E phenotypes E3/3 and E3/2 (72% of the whole group). Thus, the genetic polymorphism of apolipoprotein E may contribute to the individual risk of accelerated atherosclerosis in patients under maintenance hemodialysis.

Adult↗
PubMed1991

Prevalence of antibodies to hepatitis C virus in hemodialysis patients.

Due to frequent parenteral contact with blood transfusions hemodialysis patients are prone to acquire hepatitis C virus (HCV) infection. To determine the role of HCV infection we investigated the prevalence of antibodies to HCV in 188 hemodialysis patients. The prevalence of antibodies to HCV was 7.4%. As compared to anti-HCV-negative patients, anti-HCV-positive patients had slightly elevated transaminases which were independent of the presence of markers for hepatitis B virus infection. We conclude that HCV infection is common among dialysis patients.

Female↗
PubMed1982

Biochemistry of glomerular basement membrane of the normal and diabetic human.

HGBM were isolated from kidneys of 22 diabetic patients and 32 normal control persons. All diabetic kidneys showed severe alterations of glomerulosclerosis. The amount of basement membranes isolated from diabetic kidneys was significantly higher. The HGBM preparations were individually analyzed for phosphorus, DNA, amino acids, and carbohydrates. The cystine concentration was found to be lower in the diabetic than in normal HGBM. Contrary to other reports, there was no increase in the amounts of hydroxylysine, glucose, and galactose, nor was there a decrease in the lysine content. Glucose and mannose were shown to be significantly lower in the diabetic HGBM. The mean value for sialic acid content was lower in diabetic HGBM; the value did not reach statistical significance. This study's data could not confirm the finding of a specific alteration of diabetic HGBM as proposed previously.

Adult↗
PubMed1978

[Lactic acidosis--a possible complication in buformin-treated diabetics (author's transl)].

Lactic acidosis is defined as a state of metabolic acidosis (arterial pH below 7.36) due to an increase in the blood concentration of lactate above 2 mEq/l. Lactic acidosis may occur under a variety of conditions; the biguanide-induced lactic acidosis is due to the toxic effects of biguanides (buformin, metformin, phenformin). The clinical picture is characterized by the occurrence of disturbances of consciousness, severe acidosis with Kussmaul's respiration, shock, hypothermia and in about 30% of all cases hypoglycemia. Apart from the general principles of intensive medical care, therapy should comprise correction of the acid-base-disturbances and elimination of the offending biguanide. The efficacy of hemodialysis in the treatment of biguanide-induced lactic acidosis is difficult to evaluate. By a more sensible use of biguanides, lactic acidosis secondary to drug administration should become a rare event.

Acidosis↗
PubMed1978

Lactic acidosis.

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Acidosis↗
PubMed1976

Intramural hematoma of the esophagus: a complication of carbon tetrachloride intoxication with acute renal failure.

Following a period of prolonged severe vomiting, an intramural esophageal hematoma could be demonstrated by endoscopy and by X-ray in a 21 year old patient with hepatic and renal failure after exposure to carbon tetrachloride. The hematoma resolved spontaneously. The intramural hematoma is thought to have developed from a microdissection of the esophageal wall in the presence of a hemorrhagic diathesis.

Acute Kidney Injury↗