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Biomedical subjects

D Dimitrakov

Publications and source records attributed to D Dimitrakov.

At least 55 records · Page 3Linked to original sources
PubMed1988

[Renal onset of multiple myeloma].

67 patients with multiple myeloma with different duration and stage were studied. In 12 patients (17.91%) the onset of the disease was manifested by renal symptoms which were mistaken for primary renal disease. This group of patients was compared with the patients with usual onset of the disease by clinical, paraclinical and immunologic parameters. 75% of the patients with renal onset were in the III stage of the disease when the correct diagnosis was made. A tendency toward normal proteinuria (80.6 +/- 12.04 g/l), stable azotemia (creatinine 497.83 +/- 313.96 mmol/l), significant and non-selective proteinuria, positive correlation with light-chain secretion (r = +0.77) and lack of therapeutic response in 41.66% of the patients were found. Suggestions about the frequency, characteristics, diagnostic problems, therapeutic responses and the unfavourable prognosis of multiple myeloma with renal onset are put forward.

Adrenal Cortex Hormones↗
PubMed1986

[Middle molecule level and myocardial contractility in kidney patients].

Myocardial contractility was studied in 50 patients, 30 of them in compensated stage and 20 with terminal chronic renal insufficiency via polycardiographic method, depending on the level of the substances with mean molecular weight in serum. No statistically significant changes in the parameters of polycardiogram were established in the patients with compensated renal function, nor in the level of "mean molecules" in serum, whereas a hypodynamic phase syndrome and energodynamic heart insufficiency were established in the terminal stage of chronic renal insufficiency, accompanied with significant increase of the level of the "mean molecules" in the serum of uremic patients.

Adolescent↗
PubMed1985

[Acute renal insufficiency in a patient with intra- and extracapillary Henoch's nephritis].

Case is described with acute renal failure in Henoch's nephritis with intra- and extracapillary cellular proliferation. The disease was manifested with its classical picture: characteristic purpura, articular pains in the wrist and ankle joints, mucous-bloody diarrhea. The renal changes originated at the very beginning of the hemorrhagic vasculitis and clinically was manifested with acute renal failure and severe nephrotic syndrome. Under the effect of hemodialysis and complex drug treatment with cytostatics, glucocorticoids, anticoagulants, plasma- and bloodtransfusions, a very good clinical and paraclinical effect was attained. No recurrences of the main disease were recorded during the six-year clinical observation. A stability of the renal function was observed in the patient, with the exception of the persiting proteinuria with values under 10 g/l.

Acute Kidney Injury↗
PubMed1985

[Porphyrin biosynthesis in patients with acute and chronic kidney failure treated by hemodialysis].

Biosynthesis of porphyrin in erythrocytes was studied in 48 patients, 23 of them being with acute renal insufficiency (ARI) and 25--with terminal chronic renal insufficiency (CRI), after incubation of delta-aminolevulinic acid (synthesized uro- copro- and protoporphyrin), synthesized porphobilinogen, the activity of porphobilinogen-synthesis, erythropoietic activity of serum and hematological indices. The biosynthesis of porphyrins in both groups of patients was established to be reduced, more strongly in those with CRI that could serve as one of the criteria in the differentiation of ARI from CRI. After the discontinuation of the treatment, the biosynthesis of porphyrins in the patients with ARI approached that of the clinically healthy subjects. In the patients with CRI, included in the programmed hemodialysis treatment, the biosynthesis of porphyrins was intensified and that of synthesized protoporphyrins--considerably reduced.

Acute Kidney Injury↗