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D Djordjević

Publications and source records attributed to D Djordjević.

At least 19 recordsLinked to original sources
PubMed1998

Ethanol interactions with other cytochrome P450 substrates including drugs, xenobiotics, and carcinogens.

Chronic ethanol abuse is associated with increased activity of the microsomal ethanol-oxidizing system. This effect is due primarily to induction by ethanol of a specific cytochrome P450 (CYP2E1) responsible for enhanced oxidation of ethanol and other P450 substrates and, consequently, for metabolic tolerance to these substances. Furthermore, cytochrome 450 induction increases the activation of numerous xenobiotics to toxic metabolites and of chemical carcinogens to reactive metabolites, thereby accelerating their adverse effects. Microsomal enzyme induction has been associated with increased reactive oxygen species production and enhanced lipid peroxidation, as well as with decreased enzymatic and nonenzymatic scavenger activity, providing another possible explanation for ethanol-mediated toxicity. Yet another effect of chronic alcohol abuse is chronic immune system activation, which is the mechanism underlying alcohol-related liver disease. The metabolism of steroids and vitamins is catalyzed by P450 and is altered in chronic alcoholics. This article reviews recent advances in the understanding of ethanol interactions with drugs, toxic agents, and carcinogens, as well as with steroids and vitamins.

Acetaminophen↗
PubMed1993

[Epidemiology of Lyme borreliosis].

Our prospective study covered 1093 patients with epidemiological features and demonstrable clinical manifestations of Lyme borreliosis from 1987 to 1992. Basic criteria for the inclusion of our patients in the study were: tick bite, erythema migrans and antibodies to B. burgdorferi in each patient's serum. Various clinical manifestations were found un 1034 (94.6%) patients out of whom 829 (80.2%) had a history of tick bite, 901 (87.1%) had erythema migrans and 217 (21.0%) had serologic confirmation of the diagnosis. Inapparent infection was discovered in 59 (5.4%) patients. Other Types of skin changes (II and III stage) were found in 123 (11.9%) patients. The disease resulted in neurologic, joint and cardiac manifestations in somewhat lower percentage of patients (6.3%, 6.6% and 1.5%, respectively). In the three-year period (1990-1992) microscopic examination of the ticks (Ixodes ricinus) collected at several green areas of Belgrade confirmed the presence of B. burgdorferi in 29.1 per cent.

Humans↗
PubMed1993

[Investigational methods in Lyme disease].

After the first clinical case of Lyme disease had been recorded in Belgrade in 1987 a multi-level research of the disease was undertaken in our country. The research was organized on the team basis and was systematized. Ever since the beginning epidemiological method has been applied. Professional approach was provided by guidelines, while methods and research stages have been provided and further developed during seminars and symposiums dealing with lyme disease. Research team was comprised of experts from Institute of Public Health of Belgrade, Institute for Preventive Medicine of the Medical Military Academy and clinicians--specialists in the relevant areas. The team gathered its own precious experience in Lyme borreliosis, the disease with precisely defined features and well-described manifestations and characteristics. This work describes methodology applied in the research of Lyme disease in our country.

Animals↗
PubMed1993

[Epidemiologic characteristics and serologic findings in erythema migrans].

Our three-year research covered 417 patients with erythema migrans, of both sexes and all age groups. Among them 87.3% had a history of tick bite. Average attachment of tick to a patients skin was two days. Diameter of erythematous lesions was 1-50 cm (with an average of 15.1 cm). Magnitude of the lesion does not correlate with the further development of the Lyme disease. IFA test detected antibodies against Borreliae burgdorferi in 27.0% of our patients.

Adult↗
PubMed1993

[Lyme borreliosis in Belgrade].

In the period 1990-1992 in Belgrade area a diagnosis of Lyme disease was registered in 487 patients. There were 195 men and 292 women. The disease was registered in all ages groups, median age 38 y. The tick bite has been confirmed in 379 (77.8%) patients. Erythema migrans was the first sign of illness in 387 (84.6%) patients. The disease resoted in neurologic symptoms in 1.8%, joint manifestation in 4.8% and cardiac involvement in 0.9%. Antibodies to Borrelia burgdorferi have been detected by indirect immunofluorescence microscopy in 23.4%. Lyme disease has been registered in all districts of Belgrade. Acarological investigations have detected an infection by Borrelia burgdorferi in 29.0% of investigated ticks.

Adolescent↗
PubMed1993

[Lyme disease in human medicine].

Six years of investigations of Lyme disease in our country has offered an opportunity for better understanding of this "new" illness, which is both a medical and a health problem. The number of patients with Lyme disease is found to be similar to the number of patients in other countries. Human infections occur in different areas, rural and urban settings. A high level of collected ticks with Borrelia burgdorferi, suggests a considerable risk of human infection after a tick bite. Difficulties in diagnosing of Lyme disease are connected with different clinical symptoms and signs of the illness a poor health service personnel knowledge og the disease, and the lack of reliable and more convenient laboratory tests for confirmation of the diagnosis. A team work and a multidisciplinary aspect in the investigations and the routine work provide a solid base for a better understanding and gathering much more experience in this field. The individual protection remains a basic control measure, and each person can do the most for self protection. An activity in the health education is also of a very great importance.

Humans↗
PubMed1993

[Ecology of Borrelia burgdorferi].

Much still remains to be understood about ecology of Borrelia burgdorferi which is transmitted by a number of ticks belonging primarily to the Ixodes complex, known to feed on different animal hosts and humans. This article pretends to be a review of previous knowledge of Borrelia burgdorferi ecology. Special emphasis is placed on the preliminary results of an investigation conducted in Yugoslavia on the risk of developing lyme borreliosis after a tick bite (Ixodes ricinus). Lyme borreliosis was studied prospectively in 147 persons with tick fastened on them. Dark-field microscopic examination of tick mitgut revealed that 11 (7.9%) od 147 Ixodes ricinus were infected with Borrelia burgdorferi. Lyme borreliosis was demonstrated in only one (0.6%) of all persons bitten by ticks infected with Borrelia burgdorferi. In conclusion, these preliminary data indicate that in Yugoslavia lyme borreliosis infrequently occurred after a tick bite.

Animals↗
PubMed1993

[Vectors of Borrelia burgdorferi].

During the period 1990-1992-5,915 ticks were collected and identified in the area of Belgrade. Identification has shown that 99.8% were Ixodes ricinus and 0.2% Dermacentor marginatus. Infection with Borrelia burgdorferi was found in 27.0% to 31.7%. Females were more often infected than males and nymphs more often than larvae. Tick infection was at lowest degree in parks, little bit higher in woods and highest in mixed park-wood areas. Out of 28 locations, six can not be defined as foci of Lyme borreliosis, two are defined as potential foci and 20 as active foci of Lyme borreliosis. In a three year period we have isolated Borrelia burgdorferi in five occasions; in one occasion from ticks collected in Barajevo and in four occasions from ticks collected in Kosutnjak.

Animals↗
PubMed1993

[A theoretical model for the study of Lyme borreliosis].

This article is a short review of: a) development of theory on natural foci of communicable diseases in man, b) methodological approach to the investigation of natural foci, e.g. theoretical model in their investigation, and c) the use of theoretical model in the investigation of Lyme borreliosis. A great number of multidisciplinary studies on natural foci zooanthroponoses conducted through many years, in which ecological approach and numerous methods were applied, commencing from studies of the processes at the level of molecules, genes, cells, tissues, organismus, populations and species, contributed to the knowledge that epizootical process of natural foci of zooanthroponoses is almost an ideal natural model. Its investigation allows the establishment of the rules of epidemiological process which, for many reasons (ethical above all), is not accessible for experimental studies. On these principles a general block model has been worked out, which serves for the estimation of epidemiological manifestations of natural foci zooanthroponoses, and which, applied to Lyme borreliosis, enables the determination of active and potential foci and the estimation of the degree of risk of man infection in determined foci. Data obtained in such a way allow planning and application of adequate preventive measures.

Disease Reservoirs↗
PubMed1993

[The first isolation of Borrelia burgdorferi in Apodemus flavicollis in Yugoslavia].

Small rodent species, as well as their ectoparasitic fauna, and the presence of Borrelia burgdorferi in their blood and internal organs (liver and spleen) was investigated, at two locations (Kosutnjak, Lipovicka suma) in Belgrade. Animals were caught between September 15-17, 1992. On location Kosutnjak two Apodemus flavicollis were trapped and Borrelia burgdorferi was isolated from the spleen of one of them. On location Lipovicka suma 13 rodents were trapped as follows: 10 Apodemus flavicollis, 2 Apodemus agrarius and one Mus musculus. In these the presence of Borrelia burgdorferi was not determined. Ectoparasits Ixodes ricinus, Nesopyllus fasciatus and Haemogamasus spp. have been found. The location Kosutnjak can be considered as an active focus of lyme borreliosis.

Animals↗
PubMed1992

Long-term follow up of serum thyroglobin levels and its clinical implications in subjects after surgical removal of "cold" thyroid nodule.

Increased thyroglobulin (Tg) serum level in females (n = 49) suffering from scintigraphically "cold" thyroid nodule (395 +/- 168, micrograms/l, mean +/- SD) is significantly higher (p less than 0.001) in comparison with the data obtained from euthyroid healthy persons (28 +/- 10, n = 15) or those diagnosed with scintigraphically functional thyroid nodule (72 +/- 14, n = 15). No correlation between Tg and TSH serum levels has been seen before surgical removal of "cold" nodule (rxy = +0.34). In 49 out of 75 cases (65.3%) struma colloids were confirmed pathohistologically. After surgery, "cold" thyroid nodule was removed, serum Tg level decreased progressively within several days and three months afterwards, Tg level in most patients was mainly within the normal range for a healthy subject. The positive correlation between Tg and TSH was established three months after surgical removal of the nodule (rxy = +0.90). An elevation of serum Tg level was found in 16 out of the 49 patients during different postoperative periods (from 2 to 9 years). Under thyroxine treatment, in most of these patients a significant decrease of serum Tg level was observed. However, in a few treated patients, no change in Tg level was seen. Further clinical control in thyroxine-nonsuppressive patients discovered a compensatory hypertrophy of thyroid tissue and the appearance of a new thyroid nodule later. Present data and clinical experience suggest that long-term follow-up of serum Tg level in patients after surgical removal of "cold" thyroid nodule, brings about to early diagnosis of thyroid tissue postoperative hypertrophy before the appearance of thyroid gland nodule relapse.

Adult↗
PubMedDate not supplied

[Autonomic neuropathy with cauda equina syndrome in a patient with diabetes mellitus].

In significant number of diabetic patients are observed numerous complications during the disease onset and course. One of the most frequent is diabetic polyneuropathy that can, during its course, assume such types and imitate various diseases that can by the intensity of revealance be prominent and couse significant differential-diagnostic difficulties, especially if some forms of polyneuropathy are more rarely considered. The patient with poorly regulated diabetes, in whom the couse of disturbances was unknown for the longer period of time was presented in this study. Leading clinical phenomenology indicated the signs of impairment of cauda equina roots and extensive diagnostic procedures had to be performed. However, just after the favorable response to the glycemia regulation and withdrawal of neurologic phenomenology it was concluded that the patient suffered from diabetic polyneuropathy with clear signs of autonomic nervous system involvement, as well as autonomic neuropathy at the some time, respectively.

Autonomic Nervous System Diseases↗
PubMedDate not supplied

[Multiple sclerosis and epilepsy].

Epileptic seizures in the patients with multiple sclerosis (MS) were reported more than 100 years ago. The question of mutual physiopathologic association between MS and epilepsy is even nowadays controversial. The question is if epileptic seizures are the symptoms of MS or are just coincidential, i.e., are those two separate neurological diseases? The development of contemporary immunologic, electrophysiologic and neuroradiological diagnostic procedures enabled the diagnosis of MS to be much more certain, and in that way the differentiation of some symptoms and signs, as well as epileptic seizures in those patients became more reliable. In this report are presented three patients in whom the diagnosis of MS was confirmed by clinical, laboratory, immunological, electrophysiological and neuroradiological diagnostic analyses and procedures, and in whom were simultaneously clinically and/or electrophysiologically (EEG) registered epileptic seizures with specific alterations in EEG that were obviously associated with the development of primary disease--MS.

Adult↗