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Biomedical subjects

D Doĭchinov

Publications and source records attributed to D Doĭchinov.

At least 19 recordsLinked to original sources
PubMed1990

[Hypokalemic nephropathy from the chronic use of diuretics and laxatives].

The cases of two women with morphologically proved hypokalemic nephropathy related to chronic use of diuretics and purgatives are reported. The disease has been detected because of reduced urine quantity, increase of body mass and edema. The serum protein level is low. Sodium and potassium clearances are reduced. There is a metabolic alkalosis, serum renin and aldosterone levels are elevated. The histologic picture is typical with tubule cell vacuolization and sclerotic changes in the interstitium. The timely discovery of the cause of the disease leads to the discontinuance of the use of diuretics and purgatives and to complete recovery.

Adult↗
PubMed1988

[An acute recurrence of focal-segmental glomerulosclerosis in a kidney transplanted from mother to son with a rapid decline in kidney function].

A case is presented of a 19-year-old man suffering from focal-segmental glomerulosclerosis with terminal chronic renal failure to whom a kidney taken from his mother was transplanted. There was high blood-group and tissue compatibility between mother and son. The initial result was good, the transplanted kidney functioned well-diuresis of 3300 ml with high proteinuria. Gradually the diuresis fell to 100-200 ml. From the 29th day following the transplantation pulse urbason therapy was applied for 3 days but without effect. This led to the resumption of hemodialysis and removal of the transplanted kidney. The microscopic examination of the kidney revealed massive focal-segmental glomerulosclerosis which had led to terminal chronic renal failure. The rapid severe relapse of the disease in the transplanted kidney is explained with the malignancy of the disease and the very high compatibility between donor and recipient. It is recommended that renal transplantation in patients with focal-segmental glomerulosclerosis should not be performed with a kidney taken from a parent.

Acute Disease↗
PubMed1988

[Rapidly progressing glomerulonephritis developing against a background of idiopathic nephrotic syndrome].

A case is presented of a woman with idiopathic nephrotic syndrome--mesangioproliferative glomerulonephritis who after a 7-year therapeutic remission developed a rapidly progressing (semilunar) glomerulonephritis with a severe nephrotic syndrome, arterial hypertension, anemia, renal failure. The patient was not influenced by the treatment with ordinary doses of glucocorticosteroids and temporarily improved by the combined "pulse" methylprednisolone, immunosuppressive and heparin treatment. The possible pathogenetic mechanisms which may have played a role in the transition of the idiopathic nephrotic syndrome into a rapidly progressing glomerulonephritis are discussed.

Adolescent↗
PubMed1987

[Clinical, laboratory and morphological characteristics of mesangioproliferative glomerulonephritis].

The mesangioproliferative glomerulonephritis (MPGN) is the most frequent morphological type of primary glomerulonephritis and it was found in 42.7% of the patients studied. The MPGN is not a single nosologic entity which is proved by the immunofluorescent findings, clinical and laboratory characteristics. Several immunofluorescent types with characteristic clinico-laboratory constellation and different etiopathogenesis could be defined. The most clearly defined types of MPGN are those with leading IgA and IgM precipitates. The similar immunofluorescent findings, clinico-laboratory characteristics, course and susceptibility to symptomatic and pathogenetic treatment in MPGN with leading IgG and C3 precipitates lead to the suggestion that there may exist different "phase" states in the course of the different types of MPGN. In spite of some characteristic differences in the symptomatology and course of the different types of MPGN their differentiation is possible only by kidney biopsy.

Adult↗
PubMed1985

[Acute papillary necrosis in transplanted kidney].

After a short literature survey, indicating the rarity of acute papillary necrosis in transplanted kidneys, the authors reported one of their patients, aged 32, with transplanted dead body kidney from a male, aged 30, with blood group compatibility and compatibility of two antigens in locus A. Two hemodialysis were necessiated because of acute tubular necrosis in the transplant. After the second one, performed 10 days after the transplantation, the patient felt very strong pains in the region of the transplant, edema around it and hypovolemic shock. The kidney was explanted and necrosis of the majority of the papillae in it--established, and around it--blood collection. After that incidence, the patients had three severe gastrointestinal hemorrhages with shocks, that necessitated profuse transfusion of blood. Their cause was a small erosion, about a lentil seed, at the pyloric opening, resulting from the cortico-therapy and periodic heparinization for dialysis. The patients was reanimated and returned to programmed chroniodialysis. The possible causes for papillary necrosis are discussed, most acceptable being two of them them--urostasis from 1200 ml urine in the urinary bladder, that required catheterization before the incidence and/or compression and ischemia of the transplanted kidney by the blood collection around it.

Acute Disease↗
PubMed1985

[Acute recurrence of focal-segmental glomerulosclerosis in the kidney transplanted from mother to son with rapidly progressing failure of renal function].

After a brief survey, stressing upon the high susceptibility of the focal-segmental glomerulosclerosis to recurrences in transplated kidney, the authors announced one of their own observations on a youth, aged 19, that was transplated a kidney from a living donor--his mother. The basic disease in the acceptor led to chroniodialysis after 20 months of the first clinical signs. In spite of the high diuresis, that was observed after the transplantation of the maternal kidney, proteinuria persisted as early as the first days after the transplantation, creatinine did not reach the normal values and after I month chroniodialysis was again included, followed by detransplantation. The cause of that malignant course of the disease and in the transplanted kidney, the authors admitted to be the high tissue compatibility between the donor-mother and acceptor--son, one antigen in locus A and two antigens in loci B and DR. They think that with a malignant course of the focal segmental glomurolosclerosis, living donor for kidney transplantation should not be used and on no account--in case of high tissue compatibility.

Acute Disease↗
PubMed1984

[Acute interstitial nephritis with iridocyclitis].

One case with acute interstitial nephritis with undistinguished etiology, accompanied by iridocyclitis is described. Recently, numerous communications about similar cases have been reported which justify the differentiation of the syndrome "interstitial nephritis-iridocyclitis" among the acute interstitial nephritis. The case is of certain interest because of some characteristics: involvement of liver in the morbid process, immunemorphological finding from that described by other authors. Assumptions are presented about the pathogenetic mechanism of the disease. Conclusions are drawn in connection with the corticosteroid treatment, having induced a considerable improvement.

Acute Disease↗
PubMed1982

[Acute papillary necrosis in the transplanted kidney].

After a brief literature survey revealing the rarity of the papillary necrosis in transplanted kidneys, the authors report the case of one of their patients, aged 32, transplanted a corpse kidney of a 30-year old male with blood-group compatibility and with coincidence of the two antigens in locus A. Regardless of the increased diuresis of the patient to 3-4 1 within 24 hours, its nitrogen bodies persisted their elevation, necessitating two dialysis. After the second dialysis performed on the tenth day after the transplantation, the patient had very strong pains in the transplantation region, edema around it and a hypovolemic shock. The kidney was explanted and at the examination--necrosis of all papillae in it was established. Blood collection was found round the kidney. The same patient, after that incidence, suffered three successive severe gastrointestinal hemorrhages with shock that necessitated abundant blood transfusions. The cause was a small erosion, about the size of a millet, at the pyloric lumen, result from corticotherapy and favoured by the periodical heparinization during the following hemodialysis. The patient was reanimated and put again on a programmed chroniodialysis.

Acute Disease↗
PubMed1982

[Case of Fabry's disease].

A patient is described, admitted to the clinic on the occasion of proteinuria, edemas and arterial hypertension. The clinical and paraclinical data formed the picture of a renal involvement of mainly glomerular type with proteinuria to 5 gr%0, nonselective type, edemas, hypertension and data of chronic renal insufficiency I degree (serum creatinine to 3.8%, blood urea to 112 mg%). What impresses are the extrarenal manifestations as paresthesia of the lower limbs, with a sense of numbness to acute burning pain, a rich psychonervous symptomatics. The skin efflorescence, followed up and observed at the clinic of dermatology and the puncture biopsy material from the kidney revealed specific signs of Fabry syndrome.

Adult↗
PubMed1979

[Benign course of focal-segmental glomerulonephritis due to antibodies to the glomerular basement membrane].

The authors describe a patient with focal-segmental glomerulonephritis with a benign progress, induced by antibodies to glomerular basement membrane. Clinically the disease advanced in the course of 10 years with painless macroscopic hematuria and persisting microscopic hematuria during the intervals. Histologically, a focal-segmental glomerulonephritis was established, with crescents in certain glomeruli and immunomorphologically with linear depositis of IgG, C3 and febrin.

Adolescent↗