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Biomedical subjects

D Duś

Publications and source records attributed to D Duś.

42 records · Page 3Linked to original sources
PubMed1980

Cytostatic activity in vitro of cycloleucine, aspartic acid and glutamic acid phosphonic analogues.

Cytostatic activity of 18 new phosphonic acid derivatives of cycloleucine, aspartic acid and glutamic acid was tested against human KB and mouse L1210s leukemia cell lines in vitro. The tests were performed according to international protocol 1.600 for screening of chemical agents against tissue culture system. Four of the tested compounds revealed their cytostatic activity at the dose 10 micrograms/ml.

Amino Acids↗
PubMed1976

AKR mouse leukemia cells in tissue culture. I. Establishment of leukemic cell line AKR 87 and its morphologic and biologic characteristics.

A line of AKR leukemic mouse cells cultured in vitro, designated AKR 87, was established and characterized. Two types of cells were distinguished in this line fibroblasts and lymphoblasts. The lymphoblast-like cells resembled the original tumor cells spontaneous leukemia of AKR mice. In the XC test, cells of this line reacted specifically with XC cells, forming syncytia characteristic of cells infected with mouse leukemia viruses. Ultrathin sections of cells of this line examined on the electron microscope showed presence of type C viral particles.

AKR murine leukemia virus↗
PubMed1976

AKR mouse leukemic cells in tissue culture. II. Immunologic studies on the AKR 87 cell line.

The continuous AKR 87 cell line was derived from the thymus and spleen of AKR mice with spontaneous leukemia. Previous studies showed that the line has retained the original morphologic features of leukemic cells, reacts positively in the XC test, and produces virus particles of type C morphology. The present paper presents an immunologic characterization of cells of the AKR 87 line and of the virus produced by them, in comparison with the cells of spontaneous leukemia of AKR mice, TGV line productively infected with Gross virus, and normal mouse tissues. Results of the hemagglutination test, immunoprecipitation in agar gel, cytotoxic test and immunofluorescence indicate that the AKR 87 line produces virus antigen of the Gross type.

AKR murine leukemia virus↗