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Biomedical subjects

D Dupont

Publications and source records attributed to D Dupont.

64 records · Page 4Linked to original sources
PubMed1981

Phase I clinical trial and pharmacology of 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (metoprine) (DDMP) and folinic acid (CF).

Escalating doses of DDMP (metoprine) (15-280 mg/m2) were administered as single oral doses 24 h before a fixed leucovorin (CF) rescue (15 mg IM every 6 h for 72 h). CNS toxicity was dose-limiting and cumulative when the drug was given more frequently than at 3-week intervals. DDMP has a very long half-life (150 h) and is extensively bound to serum proteins (88%). It diffuses into the CSF and concentrates in brain tumours and normal brain tissue (brainserum ratio 3.8-5.3). DDMP is a potentially useful drug against brain tumors. Tumor regressions were seen in two patients with epidermoid carcinomas.

Antineoplastic Agents↗
PubMedDate not supplied

[Human collagen IV lenses and epikeratoplasy in monkeys. Study of epithelial cicatrization].

A previous study showed the good tolerance of the human type IV collagen lenses implanted by epikeratoplasty in 8 monkeys. It also showed type IV collagen is a good material for the reepithelialization. But we have been interested in the stability of the epithelial healing. The ultrastructural study found anchoring structures. However these were inconstant. So the authors try to understand better the mechanisms of this synthesis of the anchoring structures and describe the future ways of this experimental study.

Animals↗
PubMedDate not supplied

[Viscous human collagen IV. Physical properties and experimental tolerance].

Viscous solutions of collagen IV have been used experimentally on rabbits and monkeys. The physical properties of the solution allow a first class visco-surgery. Tolerance is studied: degradation and absorption in the anterior chamber, intraocular pressure, endothelial effects, biological sensitivity. Good tolerance and mechanical properties are said excellent and use during human surgery has started.

Animals↗
PubMedDate not supplied

[Coma and necrotizing enteritis in Schönlein-Henoch syndrome].

Authors report one case of HENOCH-SCHONLEIN syndrome particular by the association of two serious complications of good prognosis: neurological signs with coma and necrosing enteritis necessitating an intestinal resection of 60 cm of small bowel.

Child↗
PubMedDate not supplied

[Henoch-Schoentein syndrome following duodenitis with severe denutrition from distal ileum lesions. One case (author's transl)].

A case of Henoch-Schoenlein syndrome in an 8-year old child is described. The cutaneous symptoms appeared 10 days after duodenitis with ulceration of the duodenal bulb. Severe denutrition resulting from lesions of the distal ileum total required parenteral nutrition for 38 days. The anatomo-radiological signs of gastrointestinal manifestations of the syndrome are discussed.

Child↗