PubMed Health⌕ Search

Biomedical subjects

D E Bell

Publications and source records attributed to D E Bell.

14 recordsLinked to original sources
PubMed1991

Eggs enriched in omega-3 fatty acids and alterations in lipid concentrations in plasma and lipoproteins and in blood pressure.

Effects of dietary eggs enriched with omega-3 fatty acids on lipid concentrations in plasma and lipoproteins and blood pressure were determined in 11 men and women in two groups. Group 1 consumed four omega-3 eggs per day during the first 4-wk period and four control eggs for the second 4-wk period. Group 2 ate the same number of eggs in the reverse order. Mean plasma cholesterol concentration was significantly increased by control eggs (P less than 0.01) but unchanged by omega-3 eggs. Mean plasma triglyceride concentration was decreased by omega-3 eggs but increased by control eggs. Both systolic and diastolic blood pressures were significantly lowered by omega-3 eggs in group 1 whereas only systolic pressure was significantly decreased on omega-3 eggs in group 2. The control eggs did not change blood pressure. In conclusion, the omega-3 eggs may be more healthful than the control eggs.

Adult↗
PubMed1990

Protein quality and iron bioavailability of mechanically and hand-deboned turkey meat fed to rats.

The protein quality and iron bioavailability of mechanically deboned turkey meat (MDT) and hand-deboned turkey meat (HDT) were determined in rats. The protein, fat, and moisture levels in MDT were similar to those found in HDT. The MDT, however, contained more ash, calcium, and iron than the HDT. The MDT and HDT had similar amino-acid patterns; methionine and cystine were the limiting amino acids for both products. The amino-acid scores were .97 and .98 for MDT and HDT, respectively. The protein efficiency ratio and biological value as well as the values for net protein utilization and nitrogen efficiency for growth for MDT were similar to those for HDT and reference casein (P greater than .05). The hemoglobin-regeneration efficiency values were 40, 39, and 55%, respectively, for MDT, HDT, and FeSO4 (least significant difference = 12%). The MDT contained more bioavailable iron (7.6 mg of iron per kg of meat or 4.1 mg of iron per 1,000 kcal) than the HDT (4.2 mg/kg or 2.4 mg/1,000 kcal). Mechanically deboning turkey meat did not affect its protein quality, but increased the amount of bioavailable iron.

Amino Acids↗
PubMed1990

A study of financial resources devoted to research on health problems of developing countries.

The Commission on Health Research for Development is an independent, international commission composed of 12 leaders from the fields of health research, social science research and development policy. Chaired by John Evans, the other Commissioners are Gelia Castillo, vice-chair, F. H. Abed, Sune Bergstrom, Doris Calloway, Esmat Ezzat, Demissie Habte, Walter Kamba, Adetokumbo Lucas, Adolfo Martinez-Palomo, Saburo Okita and V. Ramalingaswami. The Commission began its work in November 1987, charged with analysing the strengths, weaknesses and gaps in current research on health problems of developing countries, and making proposals and promoting action for improvement. The Commission is sponsored by a variety of foundations, bilateral donor agencies, and international organizations. The Commission's report was published in the spring of 1990. As part of the work of the Commission Secretariat, we have undertaken a study of financial resources devoted to research on the health problems of developing countries. The study which began in May 1988 has three objectives: (i) To describe the current pattern of funding for research on the health problems of developing countries. (ii) To provide a baseline against which future trends and/or new programmes can be measured. (iii) To explore the possibility of an ongoing information system on research on health problems of developing countries.

Developing Countries↗
PubMed1988

Influence of source and physical form of xanthophyll pigment on broiler pigmentation and performance.

Two experiments were conducted using 21-day-old, commercial-strain broilers to determine the effect of various commercial pigmentation products on pigmentation and bird performance. Birds received finisher/withdrawal diets that included 8% corn gluten meal or either a 2.5 or 5.0% substitution of gluten meal with Liquid OroGlo5, Dry Oroglo10, or Cromophyl-oro. When birds were slaughtered at either 48 or 51 days of age there were no differences in the birds' breast skin hue (dominant wavelength) or brightness (luminosity). Data indicated similar levels of pigmentation among birds in all treatments. Color intensity (excitation purity) values of shank and breast skin samples suggested that the liquid form of OroGlo was more effective than the dry form in pigmenting broiler skin when both forms were fed at equal calculated levels. Data indicated that actual xanthophyll intake was higher when the liquid source was fed. Body weight gain and feed efficiency among the treatments, in general, indicated that commercial pigment sources can be substituted for corn gluten meal without appreciably altering broiler performance.

Animals↗
PubMed1987

The effects of deletions in the leader sequence of cat-86, a chloramphenicol-resistance gene isolated from Bacillus pumilus.

The cat-86 gene of Bacillus pumilus, specifying a Cm-inducible CAT enzyme, was cloned previously into B. subtilis on plasmid pUB110. Various lines of evidence suggest that control of expression of this gene is at the level of translation and involves inverted complementary repeat sequences 5' to the initiation codon. A series of deletions have been generated in this region and their effects on the induction of cat-86 observed in B. subtilis, Escherichia coli and a number of ribosomal mutant strains of B. subtilis. The results indicate that the inverted complementary repeat sequences, which are capable of forming a stable stem-loop structure in the mRNA (delta G = -24.4 kcal/mol), form a barrier to translation in E. coli and B. subtilis.

Acetyltransferases↗
PubMed1987

Influence of Monoprop in controlling mold growth and improving chick performance when fed high moisture corn.

Two trials were conducted with broiler chicks from hatch to 21 days of age to study the effects of feeding high moisture corn diets with and without a mold inhibitor. Monoprop High moisture corn (HMC) diets supported growth rates and dry matter feed conversion ratios as well as dry corn diets when Monoprop was present in the feed even when the feed was seeded with moldy corn screenings. Without the mold inhibitor, body weight gains were depressed. This was not due to depressed feed intake as feed consumption for chicks on HMC diets without mold inhibitor was as high as other groups.

Animal Feed↗
PubMed1986

Influence of dietary zinc deficiency and parenteral zinc on rat liver fructose 1,6-bisphosphatase activity.

Fructose 1,6-bisphosphatase activity in liver of rats fed a zinc deficient diet was decreased to 60% of that in zinc adequate controls. Activity in the zinc deprived rats was not restored to control values by in vitro addition of EDTA. When a physiological dose of zinc was tube fed to the depleted rats, activity increased approximately 150% within 0.5 hr of the dose, and by 1 hr plateaued to a level seen in zinc adequate controls. A significant transient decrease in activity occurred following an intraperitoneal zinc load. This is reversible by in vitro addition of EDTA. These results suggest that rat liver fructose 1,6-bisphosphatase activity is highly sensitive to zinc in vivo as has been demonstrated in vitro.

Animals↗
PubMed1983

Allergic contact dermatitis to 2-bromo-2-nitropropane-1,3-diol in a hydrophilic ointment.

Seven patients are described who developed acute allergic contact dermatitis after using Eucerin cream on previously dermatitic skin for periods of time varying from 5 weeks to 2 years. Eucerin was preserved with 2-bromo-2-nitropropane-1,3-diol (BNPD) in 1978 to assist in controlling a problem with Pseudomonas aeruginosa contamination. All of our patients were BNPD and Eucerin patch test-positive. None of them was allergic to formaldehyde or to any other preservative known to be a formaldehyde donor. This was in contrast to other BNPD and other formaldehyde-releaser--sensitive patients we saw in 1979-1980, who often had positive patch test reactions throughout this group of preservatives. BNPD is difficult to patch test with because it is often an irritant, even in low concentrations. We discuss some patch test "lessons" which our experiences with these patients accentuated for us.

Adult↗
PubMed1980

Mode of action of 9-beta-D-arabinosyladenine and 1-beta-D-arabinosylcytosine on DNA synthesis in human lymphoblasts.

The effects of 9-beta-D-arabinosyladenine (AraAde), 1-beta-D-arabinosylcytosine (AraCyt) and 2'-deoxyadenosine on DNA replication in cultured human lymphoblasts (CCRF-CEM line) were studied by pulse-labeling cells with [3H]thymidine and analyzing the nascent DNA by velocity sedimentation in alkaline sucrose gradients. At doses that reduced the overall rate of DNA synthesis to 50--70% of control values, both AraAde and AraCyt profoundly inhibited the formation of new replicons, with secondary effects on chain elongation contributing to the total inhibition of DNA synthesis. In contrast, the suppression of DNA synthesis by 2'-deoxyadenosine stemmed mainly from an inhibition of chain elongation. These studies also disclosed that about 100 times more AraAde than AraCyt was required to produce a similar inhibition of DNA replication in CCRF-CEM cells. Determination of intracellular concentrations of the nucleoside triphosphates (AraCTP and AraATP) indicated to 90% inhibition of DNA synthesis was achieved at 1.6 and 25 pmol/1 . 10(6) cells, respectively. Studies with cell lysates revealed that the replicative machinery in CCRF-CEM cells is more sensitive to AraCTP than to AraATP. This finding contrasts with earlier research, in which the inhibtion of purified DNA polymerase by either AraATP of AraCTP yielded essentially the same Ki value. The difference in sensitivity of the cell lysate to these arabinonucleotides may reflect either a target enzyme other than DNA polymerase or, more plausibly, some subtle interaction of the polymerase with other components of the replicative process.

Cells, Cultured↗