PubMed Health⌕ Search

Biomedical subjects

D E Klein

Publications and source records attributed to D E Klein.

16 recordsLinked to original sources
PubMed1988

Computerization of the urologic office. Billing, record keeping, and education.

Careful initial evaluation of the options is vital to successful medical office automation. The many available software programs should be scrutinized to be certain the one chosen satisfies all one's listed needs. In addition to the usual functions expected of computers, the data gathered can be used to market the urologic practice. Word processing, spreadsheet, and database programs can enhance relations among the urologist's office, referring physicians, and patients.

Humans↗
PubMed1987

Changes in AIDS risk behaviors among homosexual male physicians and university students.

Two samples of homosexual men, 64 physicians and 58 university students, reported profound decreases in several sexual practices linked to transmission of acquired immune deficiency syndrome (AIDS). The physicians showed the greater reduction. When sociodemographic variables, health beliefs, feeling of control over outcome, mood, sexual interest before the AIDS epidemic, and medical care utilization were correlated with decrease and/or increase in AIDS risk behaviors, the clusters of variables most strongly correlated with change in risk behaviors differed between the physicians and students. Interventions designed to change behaviors in AIDS high-risk groups should be tailored for specific subgroups.

Acquired Immunodeficiency Syndrome↗
PubMed1985

Non allergic rhinitis: demography of eosinophils in nasal smear, blood total eosinophil counts and IgE levels.

Seventy-eight consecutive patients with non allergic rhinitis (negative allergy skin tests) were evaluated and classified as to possible causes using strict criteria. Sixty-one percent had vasomotor rhinitis (VMR), 33% had non allergic rhinitis with eosinophilia syndrome (NARES), 16% had sinusitis, 12% had a possible hidden allergy (elevated IgE), 4% had blood eosinophilic non allergic rhinitis (BENAR) and 2% had hypothyroidism. Some overlapping of diagnosis was present. Five per cent or greater eosinophils in the nasal smear appeared to be enough to consider the diagnosis of NARES. Sinusitis tended to be more significant in the NARES group compared to VMR. BENARS may be a new syndrome. It differs from NARES in that BENARS has markedly elevated blood eosinophilia and possibly no associated sinusitis. It is similar to NARES in that it has negative allergy skin test, normal serum IgE, and eosinophils in nasal secretions. Other causes of eosinophilia were excluded in our NARES and BENARS groups.

Adolescent↗
PubMed1979

Adverse reactions to cromolyn.

The frequency of adverse reactions (dermatitis, myositis, and gastroenteritis) to cromolyn sodium in asthmatic patients was 2% (B/375). Reactions were non-life-threatening and completely reversible. Immunologic evaluations, including skin and serum tests for immediate and delayed reactivity, all were negative. Adverse reactions to cromolyn do not appear to be based on an immunologic mechanism. Cromolyn appears to be a safe drug for the treatment of asthma.

Adolescent↗
PubMed1976

Significance of tartrazine sensitivity in chronic urticaria of unknown etiology.

Of 38 patients with chronic urticaria of unknown etiology who were evaluated for food and drug additive sensitivity, 53% (20/38) had urticaria for 1 yr or more. Total eosinophil counts were not elevated in most patients, and the frequency of atopy was found to be similar to that in a general population. Of these 38 patients, 10 (26%) had a personal history of aspirin intolerance, but elimination of aspirin did not relieve the urticaria. In a double-blind crossover challenge with 0.22 mg of tartrazine and a control, tartrazine sensitivity was found in 8% (3/38) of patients with chronic urticaria and 20% (2/10) of patients with aspirin intolerance.

Adult↗
PubMedDate not supplied

Rechallenge of patients who developed oral candidiasis or hoarseness with beclomethasone dipropionate.

Of 158 asthmatic patients who were placed on inhaled beclomethasone, 15 (9.5%) developed either hoarseness (8), oral thrush (6), or both (1). When their adverse reactions subsided, seven of these 15 patients were rechallenged with inhaled beclomethasone. These included five cases who developed hoarseness and three who developed Candidiasis. One patient had both. Oral thrush did not recur, but 60% (3/5) of patients with hoarseness had recurrence. We conclude that patients may be restarted on inhaled beclomethasone when clinically indicated; however, because of the high recurrence rate, patients who develop hoarseness should not be re-challenged. Concomitant use of oral prednisone and topical beclomethasone may increase the risk of developing hoarseness or candidiasis.

Administration, Inhalation↗
PubMedDate not supplied

Anaphylaxis to peanuts: clinical correlation to skin tests.

To determine the prevalence of peanut sensitivity in a group of patients referred for routine allergy evaluation, we skin tested 365 consecutive patients with a battery of extracts that included pollens, danders, mold, dust and peanuts. These patients were seen either in private practice or in the Allergy Clinic (Rhode Island Hospital). Of these 365 patients, 248 were found to be atopic. Eight patients had a positive scratch test to peanut extract, and four of these had a positive history of peanut sensitivity. One asymptomatic patient to peanut by history reacted to open challenge with 2 oz of peanut on two occasions. We, therefore, found that 3.2% (8 of 248) of our atopic patients had a positive skin test to peanuts and of these at least 62.5% (5 of 8) had clinical sensitivity to peanuts. No nonatopic patient reacted to peanut skin testing.

Adult↗
PubMedDate not supplied

Delayed nasal mucociliary clearance in patients with nonallergic rhinitis and nasal eosinophilia.

This study investigated nasal mucociliary clearance as related to nasal eosinophilia in nonallergic rhinitis patients using the technique of nasal saccharin challenge. Fifty-six consecutive patients with nonallergic rhinitis were evaluated with nasal cytology and saccharin challenge. A saccharin challenge time of greater than 25 minutes was considered abnormal. Twelve of 56 patients (21.4%) had nasal eosinophilia. Fifteen of 56 patients (26.8%) had prolonged nasal circulation times greater than 25 minutes, indicating delayed mucociliary clearance. Although 7 of 12 patients (58.3%) with nasal eosinophilia had delayed mucociliary clearance, only 8 of 44 patients (18.2%) without eosinophilia had circulation times longer than 25 minutes. The correlation of nasal eosinophilia with prolongation of the nasal circulation time is statistically significant (chi square 5.84, P = .0156). We postulate that damage to the nasal mucociliary system may be an etiologic factor for a subset of patients with nonallergic rhinitis and that this damage may be mediated by eosinophils.

Adult↗
PubMedDate not supplied

Latex hypersensitivity: two case reports.

For persons hypersensitive to latex, continued exposure may result in a life-threatening situation. Since 1979 reports appeared supporting evidence of urticaria, rhinitis, asthma, and anaphylaxis in association with latex exposure. We present two cases of latex hypersensitivity, patients who reacted to latex on skin-prick and radioallergosorbent tests (RAST). A 30-year-old surgeon developed reactions to latex gloves. On skin-prick testing to latex extract in saline, he was 4+. RAST latex antigen-specific IgE was 50.75 times control. The second case is that of a 24-year-old nurse who underwent multiple corrective surgeries for congenital birth defects and experienced reactions to latex. On skin-prick testing to an extract of latex in saline, she was 2+. RAST latex antigen-specific IgE was 23.37 times control. Both patients were given epinephrine and diphenhydramine and advised to use latex-free gloves and to avoid latex products. As health care personnel contact with latex products increases because of new guidelines for the prevention of sexually transmitted diseases, more adverse reactions in this subpopulation will occur.

Adult↗