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D E Sarateanu

Publications and source records attributed to D E Sarateanu.

28 records · Page 2Linked to original sources
PubMed1976

[Seasonal patterns of coronavirus infections in Hamburg].

During a serological surveillance programme between October 1974 and September 1975 in Hamburg, 1624 sera from all age groups of the population were examined for the presence of coronavirus antibodies (OC 43 agent). 61,51% of the sera showed HI-titres between 1:8 and 1:128. The geometric mean antiboty titre (GMT) for the whole group was 1:12,2. The serological seasonal pattern suggests that coronaviruses are circulating the whole year in the urban population with a prevalence in the cold and a decrease in the warm season (June). The highest incidence of seropositive reactions (82,9%) was found in the 15-24 years old individuals (GMT 1:13,8). These data indicate an increased spread of coronaviruses in this segment of the population and a marked susceptibility of the group.

Adolescent↗
PubMed1975

[Differences in the quality of vaccinia viruses with normal and abnormal post-vaccination course (with neurological complications) (author's transl)].

Conventional vaccinia strains were cultured at different temperatures, because it is known that vaccinia viruses which are human pathogens grow even at higher temperatures (41 degrees C). Neither the vaccination strains nor the vaccinia viruses which were isolated from vaccination vesicles after normal (n equals 7) or abnormal primary vaccinations (n equals 2) multiplied at higher incubation temperatures; Vaccinia viruses isolated from CSF of four patients with neurological complications behaved differently. Uninhibited growth at 41 degrees C (with high infection titres) suggest that the viruses isolated from CSF were vaccinia variants with abnormal characteristics. Accordingly, these variants morphologically formed plaques in Vero-cell cultures which were two to three times larger than those of vaccinia viruses obtained from CSF of primary vaccinated cases after only moderately severe general reactions, and which on temperature test responded like the viruses used in the original vaccination.

Child↗
PubMed1975

Vaccinia virus variants as presumable cause of vaccinial complications.

Two vaccinia viruses isolated from patients with vaccinial complications (vaccinial ulcer, postvaccinial seizures) showed qualitative differences from the original parental strain. After intradermal injection of the viruses into the rabbit marked necroses developed, which the original strains did not produce. While the parental virus did not grow on the chorioallantoic membrane at 41 degrees C after 2 days incubation, the vaccinia variant produced typical lesions at that temperature. Also the yield of infectious virus on various cell systems was 1--2.5 logs higher for the virus than for the original vaccine strain. With the plaque technique differences were seen in the appearance and size of plaques between the variant and the parental vaccinia strain. These results indicate that virus of an increased pathogenicity could be isolated from the patients and this might be causally connected with the postvaccinial complications from which they were suffering.

Animals↗
PubMed1975

[Seroimmunity against rubella 5 years after immunisation with Cendehill vaccine (author's transl)].

The HI-antibodies against rubella of 383 schoolgirls, vaccinated with the Cendehill vaccine between 1969 and 1973 were investigated 8 weeks and 1,9 to 5 years, respectively, after the immunisation. The geometric mean titer of the sera investigated was 1 : 81 in the second sera. 69% of the girls, immunized at the age of 15 to 17 years in 1973 had identical serotiters in the 1st and 2nd serum samples, whilst those vaccinated between 1969 and 1971 had only in 54% constant titers. The geometric mean titer varied between 1 : 91 and 1 : 73. 33% of those vaccinated between 1969 and 1971 and 24% of the vaccinees from 1973 had a fourfold increase in the serotiter in the second postvaccinal serum. A decrease in titer could be demonstrated between 7% to 13% in different periods. Only 1% of the sera investigated became seronegative. The fourfold increases in titers are probably due to inapparent clinical rubella infections, leading to a not undesirable booster of immunity.

Antibodies, Viral↗
PubMed1975

Serological study of coronavirus antibodies in Hamburg.

A serological study of coronaviruses with the OC 43 agent (HI-test) was undertaken in 1000 sera from the population of Hamburg. 32,7% of the sera showed HI=titers between 1 : 8 and 1 : 128. The geometric mean titer (GMT) for the whole group was 1 : 16. The frequency of seropositive reactions was highest in 244 individuals 15 to 24 years old (52,8% positive reactions, GMT 1 : 19) whilst in the older age groups (25-59 years and over 60 years old) the precentage of positive reactors was markedly lower (14,4% and 16,8%, respectively, GMT 1 : 12). Among 131 twelve to 17 years old youngsters, a seroconversion was demonstrated in paired sera in 6,8% with a 4- to 8-fold rise in HI-titer within 8 weeks.

Adolescent↗
PubMedDate not supplied

Serological surveillance of influenza in Hamburg and Munich (1976/1977).

A monthly serological survey (HI-test) of influenza infections was done in Hamburg (1083 sera) and Munich (955 sera) between June 1976-February 1977 in order to find out if environment influences the host's response to infection. A higher frequency of seropositive reactions and percentage of protective antibodies (titer 1:40 and over) was found in the population of Hamburg versus Munich. The frequency was greater in individuals over 60 years (group IV) followed by persons 25-29 years (group III) than group II (15-24 years) and group I (0-14 years). There was no difference in the percentage of seropositive reactions within the 4 age groups from Munich. The GMT values of influenza antibodies in both populations studied followed the same pattern. Antibody titers against influenza antigens were found in decreasing order: A/Victoria 3/75, A/England 23/76, A/Port Chalmers 1/73, A/New Jersey 8/76, B/Hong Kong 8/73. The possible influence of climate on the host's response is discussed.

Adolescent↗