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Biomedical subjects

D E Sullivan

Publications and source records attributed to D E Sullivan.

4 recordsLinked to original sources
PubMed1991

Tissue- and development-specific expression of HBGF-1 mRNA.

The gene for heparin-binding growth factor-1 (HBGF-1) encodes a 15.5-18 kDa polypeptide that affects the proliferation and differentiation of a broad range of mammalian cells and is widely distributed among normal adult tissues. In this study, we show that normal tissues of the adult rat express HBGF-1 transcripts in one of three patterns: a 4.4 kb mRNA was the predominant HBGF-1 transcript in brain, heart and lung; a 1.4 kb mRNA was the predominant transcript in the liver; approximately equal levels of the 1.4 and 4.4 kb mRNAs were found in the kidney. HBGF-1 expression was localized in two tissues: central nervous system expression of HBGF-1 was significantly higher in the brain stem compared to the cerebrum and cerebellum; renal expression of HBGF-1 was significantly higher in the medulla compared to the cortex. Analysis of the postnatal changes in HBGF-1 expression using the newborn rat kidney revealed that the level of HBGF-1 mRNA is low at birth and does not rise to adult levels until the seventh postnatal day. These findings demonstrate that HBGF-1 expression is specific for tissue type and stage of development.

Animals↗
PubMed1986

The effect of topical 2.5% phenylephrine and 1% tropicamide on systemic blood pressure and pulse.

A prospective double-blind trial is described in which patients were given either 1% tropicamide, 2.5% phenylephrine, a combination of the two drugs, or a placebo. Blood pressure measurements and pulse rates were determined at 5, 10 and 15 minute intervals post-instillation. No significant change in systolic or diastolic blood pressures were determined for any of the treatment groups at any of the time intervals; however, a slight but significant decrease in pulse rate was noted in some of the treatment groups. The data are analyzed according to other variables. Factors which may have influenced the findings are discussed.

Adolescent↗
PubMed1978

"Staircase" closure of lower lip defects.

Attention is called to a previously described method of closing certain common surgical defects of the lower lip. Advancement flaps are used from one or both sides, resulting in a staircase configuration. The advantages, disadvantages, and applications of the method are described.

Carcinoma, Squamous Cell↗