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Biomedical subjects

D E Wright

Publications and source records attributed to D E Wright.

104 records · Page 6Linked to original sources
PubMed1968

Feedback in behavior modification: an experimental analysis in two phobic cases.

Two illustrations of single-case research are described in which an isolated therapeutic variable was sequentially introduced, withdrawn, and reintroduced while changes in a clinically relevant behavior were measured. A claustrophobic patient and a knife-phobic patient received graduated practice in facing their phobic stimuli; length of time the claustrophobic patient stayed in a small dark room per trial, and length of time the knife-phobic patient kept knife exposed per trial were measured. In both experiments, when feedback of these time scores was withdrawn, ongoing progress was retarded. Reinstatement of feedback led to renewed improvement. In Experiment 2, adding and removing contingent verbal praise against a constant background of precise feedback did not significantly alter rate of progress.

Journal Article↗
PubMed1967

Amino acid concentrations in rumen fluid.

Methods using dialysis or ultrafiltration are described for the collection of extracellular fluid in rumen contents for analysis of amino acids. Marked differences in the concentration of aspartic acid, glutamic acid, and alanine were found in samples of either diffusate or ultrafiltrate and in clarified acidified rumen liquor. Concentrations are given for aspartic acid, glutamic acid, alanine, glycine, gamma-aminobutyric acid, valine, delta-aminovaleric acid, and leucine.

Amino Acids↗
PubMed1967

Metabolism of glycine by rumen microorganisms.

Rumen microorganisms rapidly metabolized glycine at rates varying from 0.014 to 0.241 mumole of glycine per ml per min. The main metabolic products were carbon dioxide, acetic acid, and ammonia; little glycine was incorporated into bacterial protein. Use of carboxyl or methylene-labeled glycine showed that the carbon dioxide came mainly from the carboxyl of glycine, whereas both carbons of acetic acid were derived partly from the methylene carbon of glycine and partly from carbon dioxide. The ratio of carbon-14 to nitrogen-15 in glycine isolated from the protein of rumen bacteria incubated in the presence of N(15)- and C(14)-labeled glycine indicated that most of the extracellular glycine incorporated into protein was incorporated without intervening deamination.

Animals↗
PubMed1967

Metabolism of peptides by rumen microorganisms.

Rumen microorganisms utilize tryptic peptides from Chlorella protein, forming carbon dioxide, volatile fatty acids, and bacterial protein. Peptide carbon is more efficiently converted into bacterial protein than is amino acid carbon. A progressive degradation of the peptides was demonstrated by use of columns of Sephadex G-25.

Amino Acids↗
PubMedDate not supplied

Low grip strength, impaired tongue force and hyperactivity induced by overexpression of neurotrophin-3 in mouse skeletal muscle.

Transgenic mice overexpressing neurotrophin-3 (NT-3) in skeletal muscle (mlc/NT-3 mice) develop abnormal muscle spindles in skeletal muscle and display abnormal motor function in the form of gait and locomotive disturbances. The purpose of this work was to characterize the functional consequences of NT-3 overexpression in skeletal muscle with further behavioral assessments that permitted inferences about muscle weakness in the tongue or forelimbs as well as potential central nervous system (CNS) abnormalities compared to wild-type controls. Wild-type (n=12) and mlc/NT-3 (n=12) male mice were tested in five procedures (in chronological order): lick dynamics, locomotor activity, grid ataxia, go-no-go discrimination procedure, and grip strength. Relative to wild-type mice, the mlc/NT-3 mice exhibited lower tongue force, hyperactivity, slowed limb retrieval in the grid ataxia test, similar discrimination performance, and lower grip strength. Overall, the data suggest that chronically elevated levels of NT-3 in mouse skeletal muscle cause muscle weakness in the mlc/NT-3 mice. Surprisingly, mlc/NT-3 mice also exhibited significant hyperactivity, suggesting that NT-3 overexpression in the periphery may have caused abnormalities in the CNS that are related to the cortical processing of proprioceptive afferent information.

Afferent Pathways↗
PubMedDate not supplied

Selected characteristics of cervical cancer incidence cases.

Selected demographic characteristics associated with incidence cases of uterine cervical squamous severe dysplasia and carcinoma were determined. The mean age at histologic detection for all patients with Papanicolaou smears at not greater than three-year intervals was 31.0 years, with a range of 19 to 63. Invasive carcinomas were predominantly of the microinvasive type, and the mean age of patients was 34.1 years. The mean interval for conversion from cytologic negativity or mild dysplasia was 2.2 years, and two basic patterns of conversion were recognized: (1) continuously increasing atypia and (2) retrogressive cytologic findings. Most instances of the latter type probably were due to inadequacies of cellular sampling. No significant correlation was found between conversion interval and age of patient. A case-control comparison of gravidity and parity showed statistically significantly higher values among index cases for both measures for ages 20 to 29 but not for 30 years or older, implicating youthful pregnancy as an etiologic factor in cervical carcinogenesis.

Adult↗