Biomedical subjects

D E Zinke

Publications and source records attributed to D E Zinke.

3 recordsLinked to original sources

PubMed1982

Tension pneumocephalus.

Sixteen patients with intracranial air under tension and severe neurological symptoms following trauma and neurosurgical procedures were reviewed. Computed tomography (CT) was performed in cadavers following selective air injections into the epidural, subdural, and subarachnoid spaces. The characteristic CT appearance of air in the various intracranial compartments is illustrated. The typical "peaking" of the frontal lobes in subdural tension pneumocephalus is explained by bridging veins entering the superior sagittal sinus. Stretching and rupturing of these veins may be implicated as a cause for a concomitant subdural hematoma. The various mechanisms causing tension pneumocephalus and its appropriate therapy are discussed.

Adult↗

PubMed1981

Fibromuscular dysplasia of the internal carotid artery: percutaneous transluminal angioplasty.

Percutaneous transluminal angioplasty was used to successfully dilate critical narrowings of the internal carotid artery caused by fibromuscular dysplasia. The technique of this new procedure is presented along with the angiographic findings and results in three patients. Angioplasty may be used as an alternative to open arteriotomy and graduated dilatation in treating stenosis due to symptomatic fibromuscular dysplasia in the immediate extracranial part of the internal carotid artery.

Aged↗

PubMed1981

Pathophysiology of "tethered cord syndrome".

The tethered cord syndrome is a clinical entity manifested by progressive motor and sensory changes in the legs, incontinence, back of leg pain, and scoliosis. In order to elucidate the pathophysiology involved in the tethered cord, the reduction/oxidation ratio (redox) was used in vivo of cytochrome alpha,alpha 3 to signal oxidative metabolic functioning in human examples of tethered cord and in animal models. Studies in experimental models indicate marked metabolic and electrophysiological susceptibility to hypoxic stress to lumbosacral cord under traction with greater weights (3, 4 or 5 gm). Similar effects were demonstrated in redox behavior of human tethered cord during surgical procedures. The authors conclude that symptoms and signs of tethered cord are concomitant with lumbosacral neuronal dysfunction which could be due to impairment of mitochondrial oxidative metabolism under constant or intermittent cord stretching. It is assumed that prolonged or accentuated neuronal dysfunction may lead to structural damage to the neuronal perikarya and later of the axons. Untethering procedures in human tethered cord improve oxidative metabolism, and probably facilitate the repair mechanism of injured neurons.

Action Potentials↗