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Biomedical subjects

D Elkon

Publications and source records attributed to D Elkon.

28 records · Page 2Linked to original sources
PubMed1980

Response of mouse kidney to hyperthermia: pathology and temperature--dependence of injury.

Hyperthermia either alone or in combination with radiotherapy and chemotherapy is being used increasingly in the treatment of malignant tumors. This study was designed to evaluate the response of the mouse kidney exposed to a range of hyperthermic temperatures (41 to 45 degrees C) used to induce regression of malignant tumors. Minimal histologic evidence of renal injury occurred in the proximal tubules of the subcapsular region. More extensive damage was characterized by necrosis of tubules and glomeruli in a sharply circumscribed area that involved the lateral subcapsular area where the temperature induced was highest. The tissue histologic reaction was maximal by 24 hours. At temperatures below 41 degrees C no necrosis occurred, whereas at temperatures between 42 and 45 degrees C there was an increasing incidence of necrosis. This increase in tissue reaction above 42 to 43 degrees C is consistent with reported observations from tissue culture and in vivo skin heating experiments, and indicates that normal tissue injury may occur in the same range of temperatures shown to cause regression in malignant tumors.

Animals↗
PubMed1979

Esthesioneuroblastoma.

Esthesioneuroblastoma is an uncommon tumor of neural crest origin arising in the nasal cavity. Since 1966, 97 cases have been reported in the world literature. In this report an analysis is presented of the following aspects of these 97 patients: age and sex distribution, disease staging, treatment results, interval to recurrence, and survival. Staging was according to a system proposed by Kadish et al. There is a bimodal age distribution with peaks in age groups 11-20 years and 51-60 years. Prognosis is favorable in early stage disease (A and B) with 3-year crude survivals of 88.9% and 83.3%, respectively. Stage C patients have a poor prognosis, with 52.9% surviving 3 years. Treatment consisted of radiotherapy, surgery, or a combination of radiotherapy and surgery. In stage A, prognosis is favorable in all three treatment groups with one 1 of 24 patients dying of recurrent disease. In stage B, recurrence rates and 3-year survivals are also similar in the three treatment groups. Thus, single modality treatment is as effective as combined treatment for early stage disease. Local recurrence is the predominant site of failure occurring in 68% of recurrences. The overall crude survival for the 97 patients was 95.4%, while the determinate survival (corrected for intercurrent disease) was 70.8%.

Adolescent↗
PubMed1979

The use of strontium-90 in the treatment of carcinoma in situ of the conjunctiva.

Four patients with carcinoma in situ were treated with strontium-90 beta ray application. The dose used was 4,500 rads after surgical removal or with small recurrent tumor and 7,000 rads for primary treatment. All patients were disease-free at follow-up periods of 48 to 320 months after treatment. One patient required superficial x-ray treatment for recurrent disease. No serious complications developed with the treatment and no progressive cataracts have occurred.

Aged↗
PubMed1979

Immunonephelometric assay for urinary total protein and albumin in mice.

A quantitative immunonephelometric assay for measuring total protein and albumin in mouse urine has been developed. Antisera to whole mouse sera or to mouse albumin was added to aliquots of urine and the antigen-antibody complexes formed were measured by laser nephelometry. Sample volumes were small (20 microliters) and the assay time was 90 minutes. The assays were sensitive to 10 mg/L and within-day and day-to-day precision studies demonstrated coefficients of variation of less than 15%. Average urinary total protein and albumin concentrations for random urine specimens in female C3H mice (age 80-150 days) were 42 and 24 mg/L respectively. Urinary total protein and albumin to creatinine ratios were also determined.

Albuminuria↗
PubMed1978

Radiation therapy in the treatment of malignant salivary gland tumors.

A retrospective analysis of 52 patients with malignant salivary gland tumors is reported. Seventeen patients received early postoperative radiation therapy and 16 (94%) were free of local or regional disease 2-14 years following initiation of therapy, although 14 were considered at high risk of developing local recurrence. Two subjects (12%) developed distant metastases and 14 (82%) were completely disease-free. Survival and disease-free status of patients treated for recurrent or inoperable disease were much worse with two of 13 disease-free at 45 and 168 months respectively. Various workers have reported recurrence rates after surgery along at 25-38% and over 50% for many histological types. On the basis of this report early postoperative radiation therapy is recommended to reduce the risk of postsurgical recurrence. Prognostic trends relating to both histological type and location of primary disease are discussed.

Adenocarcinoma↗