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D Emfietzoglou

Publications and source records attributed to D Emfietzoglou.

15 recordsLinked to original sources

Accurate electron inelastic cross sections and stopping powers for liquid water over the 0.1-10 keV range based on an improved dielectric description of the Bethe surface.

Electron inelastic cross sections and stopping powers for liquid water over the 0.1-10 keV range are presented based on a recently developed dielectric response model for liquid water (D. Emfietzoglou, F. Cucinotta and H. Nikjoo, Radiat. Res. 164, 202-211, 2005) that is consistent with the experimental data over the whole energy-momentum plane. Both exchange and second-order Born corrections are included in a material-specific way using the dielectric functions of liquid water. The numerical results are fitted by simple analytic functions to facilitate their further use. Compared to previous studies, differential cross sections are shifted toward smaller energy losses resulting in smaller inelastic and stopping cross sections with differences reaching, on average, the approximately 20% and approximately 50% level, respectively. Contrary to higher energies, it is shown that the dispersion model for the momentum dependence of the dielectric functions (Bethe ridge) is as important as the optical model used. Within the accuracy of the experimental data (a few percent) upon which our dielectric model is based, the calculations are "exact" to first order, while the uncertainty of the results beyond first order is estimated at the 5-10% level. The present work overcomes the limitations of Bethe's theory at low energies by a self-consistent account of inner-shell effects and may serve to extend the ICRU electron stopping power database for liquid water down to 100 eV with a level of uncertainty similar to that for the higher-energy values.

Electrons↗

A Monte-Carlo code for the detailed simulation of electron and light-ion tracks in condensed matter.

In an effort to understand the basic mechanism of the action of charged particles in solid radiation dosimeters, we extend our Monte-Carlo code (MC4) to condensed media (liquids/solids) and present new track-structure calculations for electrons and protons. Modeling the energy dissipation process is based on a model dielectric function, which accounts in a semi-empirical and self-consistent way for condensed-phase effects which are computationally intractable. Importantly, these effects mostly influence track-structure characteristics at the nanometer scale, which is the focus of radiation action models. Since the event-by-event scheme for electron transport is impractical above several kilo-electron volts, a condensed-history random-walk scheme has been implemented to transport the energetic delta rays produced by energetic ions. Based on the above developments, new track-structure calculations are presented for two representative dosimetric materials, namely, liquid water and silicon. Results include radial dose distributions in cylindrical and spherical geometries, as well as, clustering distributions, which, among other things, are important in predicting irreparable damage in biological systems and prompt electric-fields in microelectronics.

Algorithms↗

Monte-Carlo calculations of radial dose and restricted-let for protons in water.

A new Monte-Carlo code for event-by-event simulation of the transport of energetic non-relativistic protons (approximately 0.5-10 MeV) and all their secondary electrons (down to 1 Ry) in both the vapour and liquid phases of water is presented. A unified particle-water inelastic model for both phases of water has been developed based on experimental optical data and elements of the Bethe theory. The model applies to both electrons and heavy-charged particles and is particularly suitable for extension to other media of biological relevance (organic polymers, DNA, etc.). Condensed-phase effects are included in the liquid version (MC4L) by means of the dielectric functions which, essentially, substitute the oscillator-strength used in the vapour version (MC4V). The results in the form of radial dose distributions and spatially restricted linear energy transfer are presented and compared with the literature.

Algorithms↗

Monte Carlo simulation of the energy loss of low-energy electrons in liquid water.

A Monte Carlo code that performs detailed (i.e. event-by-event) simulation of the transport and energy loss of low-energy electrons (approximately 50-10 000 eV) in water in the liquid phase is presented. The inelastic model for energy loss is based on a semi-empirical dielectric-response function for the valence-shells of the liquid whereas an exchange corrected semi-classical formula was used for K-shell ionization. Following a methodology widely used for the vapour phase, we succeeded in parametrizing the dielectric cross-sections of the liquid in accordance with the Bethe asymptote, thus providing a unified approach for both phases of water and greatly facilitating the computations. Born-corrections at lower energies have been implemented in terms of a second-order perturbation term with a simple Coulomb-field correction and the use of a Mott-type exchange modification. Angular deflections were determined by empirical schemes established from vapour data. Electron tracks generated by the code were used to calculate energy- and interaction-point-kernel distributions at low electron energies in liquid water. The effect of various model assumptions (e.g., dispersion, Born-corrections, phase) on both the single-collision and slowing-down distributions is examined.

Electrons↗

Modelling the energy-loss mechanism of charged particles in organic solids.

The present study examines the energy-loss mechanism of charged particles in organic solids as determined by the inelastic interactions with the electronic sub-system of the target. The dielectric approach was applied to non-conducting valence electrons while an appropriate binary collision theory was used for core-electron transitions. The development of energy-loss models based on optical data (i.e. at zero momentum transfer) and appropriate extension algorithms (to non-zero momentum transfer) is discussed. The optical absorption spectrum is now available for a variety of organic compounds and allows for the inclusion of phase effects by incorporating pertinent experimental information. The dispersion of the optical functions is based on an analysis of the general properties of the Bethe-surface. Calculations are presented for the case of liquid water as a model substance for other condensed organic materials with very similar absorption characteristics.

Electrochemistry↗

Radiation dosimetry using three-dimensional optical random access memories.

The ability to determine particle type and energy plays an important role in the dosimetry of heavy charged particles (HCP) and neutrons. A new approach to radiation dosimetry is presented, which is shown to be capable of particle type and energy discrimination. This method is based on utilising radiation induced changes in the digital information stored on three-dimensional optical random access memories (3D ORAM). 3D ORAM is a small cube (a few mm3) composed of poly(methyl methacrylate) doped with a photochromic dye. and it was originally proposed as a memory device in high speed parallel computers. A Nd:YAG laser system is used to write and read binary information (bits) on the ORAM, which functions as a charged particle detector. Both the read and the write processes use two laser beams that simultaneously strike the material to cause a colour change at their intersection (similar to the darkening of light-sensitive sunglasses when exposed to sunlight.) The laser produces colour changes in the ORAM, which then reverts to the original colour ('bit-flips') at sites where energy is deposited from interaction with incident HCP or neutron-recoil protons. The feasibility of this approach was demonstrated both theoretically and experimentally. Calculations based on track structure theory (TST) predict that when HCP interact with the ORAM material, the local energy deposition is capable of inducing measurable 'bit-flips'. These predictions were recently confirmed experimentally using two types of ORAM systems, one based on spirobenzopyran and the other on anthracene, as the photochromic dyes.

Computer Storage Devices↗

Semi-empirical inelastic cross sections for electron transport in liquid water.

Electron inelastic cross sections for water in the liquid phase are important for developing Monte Carlo codes that simulate the full degradation of any radiation beam in biological matter. The limited experimental information for condensed targets and the complexity of the background theory has led to largely heuristic semi-empirical models. The present work makes use of the dielectric formalism under the first Born approximation to develop inelastic cross sections for low-energy electron transport in liquid water. A Drude model was used to describe the energy-loss distribution at the dipole limit on the basis of optical data, while the impulse approximation and an empirical generalised-oscillator-strength provided the extension to finite momentum transfer. Born corrections established earlier for water vapour were applied at low impact energies. Core-electron transitions were treated by a binary model with exchange terms. Sum-rules were satisfied to within 1-2% while an 1-value of about 80 eV was obtained. A comparison with other studies is provided.

Biomechanical Phenomena↗

An analytic dosimetry study for the use of radionuclide-liposome conjugates in internal radiotherapy.

UNLABELLED: A dosimetric analysis has been performed to evaluate the potential of liposome systems as carriers of radionuclides in internal radiotherapy. METHODS: Pharmacokinetic data for a variety of liposome constructs (multilamellar vesicles [MLV]; small unilamellar vesicles [SUV]; and sterically stabilized liposomes, monosialoganglioside [G(M1)]-coated) were used to obtain tumor and normal-organ absorbed dose estimates for (67)Cu, (188)Re, (90)Y, and (131)I. Dosimetry was performed for two tumor models: subcutaneous Ehrlich ascites tumor, growing intramuscularly, and C26 colon carcinoma, growing intrahepatically. Dose estimates were obtained using the MIRD schema. Tumor doses were obtained assuming local deposition of electron energy; photon contributions were incorporated assuming spheric tumor geometry. With the conservative assumption that intravenously administered liposomes achieve rapid equilibration with the red marrow extracellular fluid volume, red marrow absorbed dose estimates were obtained from blood kinetics. RESULTS: For intramuscular tumors, absorbed dose ratios for tumor to red marrow ranged from 0.93 ((131)I-MLV) to 13.9 ((90)Y-SUV). Tumor-to-liver ratios ranged from 0.08 ((188)Re-MLV) to 0.92 ((188)Re-SUV); corresponding values for tumor to spleen were 0.13 ((90)Y-MLV) and 0.54 ((188)Re-G(M1)). The optimal combination of radionuclide and liposome system was obtained with (90)Y-SUV. Tumor-to-liver ratios for the G(M1)-coated construct were greatest when the tumor was intrahepatic (1.13 for (90)Y). For a given liposome system, absorbed dose ratios for tumor to normal tissue exhibited up to a twofold variation depending on the radionuclide selected. CONCLUSION: This study provides a dosimetric evaluation for the use of some liposome systems as carriers in targeted radionuclide therapy. Although much further work must be undertaken before any clinical application is considered, these results suggest that radionuclide targeting using liposomes is feasible and may have the advantage of reduced red marrow absorbed dose.

Animals↗

Monte Carlo simulation of charged particle transport in biomatter.

Knowledge of the microscopic distribution of interactions in irradiated matter is of fundamental importance for a mechanistic understanding of subsequent effects. This may be obtained by Monte Carlo codes which simulate event-by-event the transport of charged particles in matter. The development of such codes necessitates accurate interaction cross-sections for all the important collision processes. A semi-theoretical formalism has been developed and implemented in a Monte Carlo code which fairly accurately predicts energy-loss spectra for charged particle impact on water molecules. The extension of the formalism for establishing the necessary cross-sections for liquid/solid water (i.e. more realistic biomatter) is discussed and preliminary results are presented.

Carbon↗

A Monte Carlo track structure code for electrons (approximately 10 eV-10 keV) and protons (approximately 0.3-10 MeV) in water: partitioning of energy and collision events.

An event-by-event Monte Carlo simulation code for track structure studies is described. In the present form the code transports protons (approximately 0.3-10 MeV) and electrons (approximately 10 eV-10 keV) in a water medium in the gas phase approximation. For the type of particles and energy range considered, ionization, electronic excitation and electron elastic scattering are the most important collision events accounted for in the transport simulation. Efforts were made to ensure that the analytic representation of the various interaction cross sections rests on well established experimental data and theory. For example, the secondary-electron spectrum as well as partial and total ionization cross sections are represented by a semitheoretical formulation combining Bethe's asymptotic expansion and binary-encounter theory. Binding effects for five levels of ionization and eight levels of electronic excitation of the water molecule are explicitly considered. The validity of the model cross sections is examined against available experimental data and theoretical predictions from other similar studies. Results pertaining to the partitioning of energy loss and interaction events for the first-collision probability and nanometre-size track segments are presented.

Electrons↗

A potential application to the study of microscopic energy deposition in a solid by means of heavy charged-particle induced photochromic alterations in a tissue-equivalent matrix.

A theoretical study was carried out to investigate the feasibility of using the radiation-induced colour decay of photochromic molecules embedded in a polymer matrix as a probe for studying the microscopic energy deposition of heavy charged particles (HCPs) in a tissue-equivalent solid. The theoretical treatment makes use of the radial dose distribution function as derived from gas-phase physics, together with the effects of the increase in temperature and of matrix degradation on the colour-decay kinetics of the photochromic molecules, according to empirical models derived for the solid state. Bearing in mind the non-stochastic nature of the model, the use of gas-phase physics at the level of radiation interaction, and the fact that some empirical quantities used have been established macroscopically, all factors which signify that extra caution is required in the interpretation of the results, it is shown that when the optimum information retrieval time (after track formation) is considered the technique may be able to resolve differences in the energy deposition pattern by different HCPs in the nanometre range (1-10 nm; material's mass density 1.2 g cm(-3)) from the track axis. Most importantly, though, the present study aims to erect a theoretical framework for the possible application of the technique and to highlight those aspects which are likely to be critical to its practical usage, such as particle type and energy range, and spatial scale and magnitude of the expected effect together with its dependence on time, the physical characteristics of the matrix, and the kinetic behaviour of the type of photochromic molecule studied. Furthermore, it establishes a rationale for interpreting the experimentally observed (if available) colour changes in the HCP track in terms of the microscopic distribution of energy deposition in it.

Benzopyrans↗

Simulation of radiation effects on three-dimensional computer optical memories.

A model was developed to simulate the effects of heavy charged-particle (HCP) radiation on the information stored in three-dimensional computer optical memories. The model is based on (i) the HCP track radial dose distribution, (ii) the spatial and temporal distribution of temperature in the track, (iii) the matrix-specific radiation-induced changes that will affect the response, and (iv) the kinetics of transition of photochromic molecules from the colored to the colorless isomeric form (bit flip). It is shown that information stored in a volume of several nanometers radius around the particle's track axis may be lost. The magnitude of the effect is dependent on the particle's track structure.

Biophysical Phenomena↗

Altered processing of precursor transcripts and increased levels of the subunit I of mitochondrial cytochrome c oxidase in Syrian hamster fetal cells initiated with ionizing radiation.

Treatment of Syrian hamster fetal cells (SHFC) with ionizing radiation resulted in the establishment of 21 transformed cell lines. Relative to unirradiated controls, cells from early post-irradiation passages (p.3) showed marked morphologic alterations, increased growth rate and extended life span, and they were contact-inhibited and not tumorigenic in nude mice, although they became tumorigenic after extended passaging in culture (p. > 30). Differential mRNA display analyses of normal cells (84-3) and radiation-initiated cell lines at early passage showed that the latter contained increased steady-state levels of the precursor (4-fold) and mature (1.7-fold) transcripts of the mitochondrial (mt) gene encoding the subunit I of cytochrome c oxidase (CO I). These molecular alterations were consistently observed in 57% of the irradiated (HDR) cell lines, and were stably maintained during continuous passaging (p. > 50). Further analyses of one of these cell lines (HDR-3) demonstrated that the accumulation of CO I precursor transcripts was the result of mRNA stabilization and increased replication and/or amplification of the mt DNA. Radiation-initiated cells contained elevated levels of the CO I protein, showed a 75% reduction in cytochrome c oxidase (CO) activity, and a 5-fold increase in the concentration of hydrogen peroxide secreted into their culture medium compared with cells with no alterations in CO I mRNA processing. Our findings suggest that alterations in mt CO I processing may play a role in the neoplastic conversion of mammalian cells by ionizing radiation.

Animals↗

Increased manganese superoxide dismutase activity, protein, and mRNA levels and concurrent induction of tumor necrosis factor alpha in radiation-initiated Syrian hamster cells.

The levels of the antioxidant enzyme manganese superoxide dismutase (Mn-SOD) are frequently decreased in tumor cells and increased in normal cells upon treatment with ionizing radiation. We studied Mn-SOD at different stages during the neoplastic conversion of radiation-initiated Syrian hamster embryo HDR-3 cells. Mn-SOD activity and the concentration of Mn-SOD protein and mRNA increased gradually during the malignant transformation of HDR-3 cells after radiation exposure; fully neoplastic cells showed greater Mn-SOD levels than preneoplastic and normal 84-3 cells. Inhibitors of superoxide (SO) anion production (thenoyltrifluoroacetone and rotenone) decreased the concentration of Mn-SOD mRNA, raising the possibility that the generation of SO radicals participated in the upregulation of Mn-SOD in cells transformed by exposure to radiation. We observed an increase in the concentration of tumor necrosis factor alpha (TNF alpha) in HDR-3 cells relative to mock-irradiated cells. Together with the observation that TNF alpha stimulates the production of SO by mitochondria and increases the level of Mn-SOD mRNA in other experimental systems, our results suggest that as normal 84-3 cells undergo malignant transformation induced by ionizing radiation they produce TNF alpha, to which the cells respond by increasing the concentration of Mn-SOD mRNA and protein and the activity of the enzyme.

Animals↗

Tissue dosimetry of liposome-radionuclide complexes for internal radiotherapy: toward liposome-targeted therapeutic radiopharmaceuticals.

BACKGROUND: Quantitative examination of the important physical parameters, such as the tumor absorbed dose and the tumor-to-normal-tissue (T-NT) absorbed dose ratios, for effective use of radionuclide-liposome conjugates m internal radiotherapy was carried out. METHODS: The Medical Internal Radiation Dose (MIRD) formalism was used to develop a set of dosimetric equations. Pharmacokinetic functions used as input information to the dosimetric model were derived from experimental time-biodistribution data. Multilamellar (MLV), small unilamellar (SUV) and sterically stabilized (GM1- and PEG-coated) liposomes were examined in combination with the very promising particle emitting radionuclides: 67Cu, 188Re and 211At. For comparative purposes, the widely used: 90Y and 131I were also included in the study. For all radionuclide-liposome combinations, the mean absorbed dose per amount of radioactivity administered was obtained: (i) for two different types of human xenografts located in the muscle and liver tissue, and (ii) for normal liver, spleen, kidneys, and total body. RESULTS: Regardless of radionuclide, the poorest values were obtained for the MLV liposomes. Due to more rapid uptake of sterically stabilized (GM,-coated) liposomes to the muscle tumor tissue as compared to SUVs, 211At and 188Re deliver higher tumor doses when combined with the former, while 67Cu, 90Y and 131I are more effective with SUVs. The most promising results were obtained for the [211At-GM1] complex in the liver tumor. CONCLUSION: The importance of liposome size and steric barrier when designing effective radionuclide-carrier systems was revealed, but most importantly the optimal matching between the radionuclide half-life and the time of maximum liposome accumulation ratio between the tumor and normal tissue.

Animals↗