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Biomedical subjects

D Erdmann

Publications and source records attributed to D Erdmann.

63 records · Page 4Linked to original sources
PubMed1982

[Clinical trials with localized mitomycin instillation therapy for superficial urothelial bladder carcinoma].

105 patients with transitional cell carcinoma of the bladder, stage Tis, TA, T1 were treated by a local cytostatica therapy with Mitomycin C (MMC) after transurethral resection (TUR) of the bladder with the following purposes: 1. curative therapy of the carcinoma in situ 2. avoidance of tumor cell implantation from the TUR. After a follow up of 22,3 months this therapeutic concept seems to be of great promise because of its clearly reduced recurrence rate of a total of 12,4%. Side effects are slight. Nevertheless it must be pointed out, that any definitive statement can only be made after a longterm observation, especially by multicentric, controlled, randomized studies. MMC serum resorption studies with 19 patients, partly with reflux and TUR caused perforation of the bladder, showed that MMC instillation therapy (20 mg MMC/40 ml NaCl) immediately after resection did not lead to a systemic toxic concentration.

Adult↗
PubMed1978

[A transurethrally transplanted model of a carcinoma in the area of the urinary bladder of the rabbit (author's transl)].

Thirty-nine rabbits were injected intratesticularly (n = 4), in the neck (n = 6), or in the submucosal area of the bladder (n = 29), with a 1-ml suspension of cells from a continuously passaged Brown-Pearce carcinoma. Actual submucosal transplantation (n = 9) caused, in addition to bladder tumors, massive metastases in the peritoneal cavity, the pleura, and the eyes. Animals receiving mucous membrane cornification prior to the submucosal infiltration (n = 15) developed exulcerated tumors in the bladder lumen and a primary bladder carcinoma like metastasis. Animals in which the tumor cell suspension was transplanted transurethrally (n = 5) likewise showed metastases in para-aortal lymph nodes and in the liver. The experiments indicate that the Brown-Pearce carcinoma, which is not indigenous to the bladder, will, with appropriate methodology, behave in a manner similar to that of a primary bladder carcinoma and can in addition be transplanted transurethrally. Tumors thus induced appear to be suitable models for studying different therapeutic approaches to bladder carcinoma.

Animals↗
PubMed1978

[Local high-frequency hyperthermia of the Brown-Pearce carcinoma in the urinary bladder of rabbits (author's transl)].

The effect of a conductive high-frequency hyperthermia on a model tumor in the urinary bladder of rabbits (Brown-Pearce Carcinoma) was studied at a temperature of 43 degrees C, and with an application time of 30 min. The frequency used was 500 kHz, wattage 30-300 and wavelength 600 m. This resulted in the homogeneous warming of the urinary bladder tissue, in contrast to the results obtained when warm water was injected. Essential test results included: (1) a temperature gradient of max. 6.7 degrees C from the tumor center to the lumen of the urinary bladder, the tumor favoring the higher temperatures; (2) a prolongation of the survival time for animals with heat-treated tumors as opposed to the control animals. After transplantation heat-treated tumors evolved to receptor animals considerably less often than did untreated tumors.

Animals↗