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Biomedical subjects

D Esser

Publications and source records attributed to D Esser.

24 records · Page 2Linked to original sources

[Functional and morphologic results of pedicled and microvascular anastomosis in tissue transfer].

UNLABELLED: From 1982 to 1992, large intraoral and pharyngeal soft-tissue defects were reconstructed using myocutaneous island flaps in 95 patients, free jejunal interpositions in 10 patients and forearm flaps in 18 patients at the Magdeburg School of Medicine, Department and Clinic of Otorhinolaryngology. Sixty-five patients were followed up after various time periods in order to assess the functional results. Investigation and evaluation of the individual patients' resultant quality of life were based on a specifically prepared examination questionnaire. In particular, the evaluation included: the mouth opening gap, motility of the tongue, sufficient masticatory area, adequate provision to fit artificial teeth, malocclusion, the extent of mandibular deviation, assessment of the swallowing act, articulation disturbances, paraesthesia, function accessory nerve, atrophy of the trapezius muscle, motility of the cervical spine, flexibility in the shoulder girdle, as well as subjective information obtained from the patients (pain, feeling of dryness, increased salivation, occupational rehabilitation, organisation of leisure time). In 45 patients, biopsy material from the transferred tissue was examined at varied time intervals after primary therapy. IN CONCLUSION: The functional results obtained for the myocutaneous island flaps, the forearm flap and the free jejunal interposition were satisfactory, and only minor differences were noted. From the morphological point of view, all the three types of tissue transfer were found to have adapted adequately to the recipient site.

Anastomosis, Surgical↗

Increased prostaglandin PGE2 and 6-keto-PGF1 alpha immunoactivity in incubates of gastric mucosa and forestomach of nephrectomized rats.

Prostaglandin E2 (PGE2)- and 6-keto-PGF1 alpha-like immunoactivity was measured in incubates of forestomach and gastric corpus mucosa in (a) unoperated rats, (b) rats with sham-operation of the kidneys and (c) rats with bilateral nephrectomy. In addition the mean ulcer area in the forestomach and gastric mucosa was assayed in all three groups of rats. The PGE2- and 6-keto-PGF1 alpha-like immunoactivity in gastric mucosa incubates and 6-keto-PGF1 alpha in the forestomach incubates was almost the same in unoperated and sham-operated rats. Increased 6-keto-PGF1 alpha in the forestomach and of PGE2 and 6-keto-PGF1 alpha in the gastric mucosa was found in rats with bilateral nephrectomy before gastric lesions were seen. A higher mean ulcer area occurred in the forestomach and gastric mucosa 24-48 h after bilateral nephrectomy. We conclude, that the increased PGE2- and 6-keto-PGF1 alpha production by the gastric mucosa and forestomach was associated with the loss of normal renal tissue function. Despite the protection of PGE2 and PGI2 by gastric tissue, gastric lesions nevertheless occur in acute uraemic rats.

6-Ketoprostaglandin F1 alpha↗

[The value of sonography in the differential diagnosis of soft tissue tumors].

A total of 379 patients with soft tissue swellings of unclear aetiology underwent a prospective examination with a high-resolution linear scanner during an interdisciplinary study. We diagnosed 112 true soft tissue tumours, 42 peripheric soft tissue metastases, 34 lymph node metastases, 106 tumour-simulating diseases, 56 inflammatory diseases, and 29 vascular alterations. Eighty-eight per cent of the cases were given the correct differential diagnostic classification by means of sonography. Assessment of malignancy ist not possible by means of sonography.

Diagnosis, Differential↗

Total parenteral nutrition for the treatment of severe hyperemesis gravidarum: maternal nutritional effects and fetal outcome.

Hyperemesis gravidarum is a complication of pregnancy that can lead to severe maternal nutritional deprivation. Total parenteral nutrition has been used in pregnancy complicated by hyperemesis gravidarum. However, little has been done to study the nutritional aspects of hyperemesis or the maternal effects of total parenteral nutrition when given during the first trimester of pregnancy. The purpose of this study was to examine the nutritional state of pregnancy complicated by hyperemesis gravidarum and the effects of total parenteral nutrition on maternal nutrition and fetal outcome when given during the first trimester of pregnancy. Using a standard method of indirect calorimetry, the basal metabolic expenditure and adjusted metabolic expenditure were determined, and appropriate calories were calculated for each patient. The patients were then started on total parenteral nutrition. Follow-up indirect calorimetry studies showed improved nutritional status, with return of anabolic parameters. The results of this study support the conclusion that total parenteral nutrition given during the first trimester is a safe and effective method of nutritional support.

Birth Weight↗

Fractures of the triquetrum in children.

Fractures of the triquetrum are a more common cause of posttraumatic wrist pain in children than is usually appreciated. These fractures are often very subtle "flake" avulsion or impingement fractures requiring good oblique radiographs for recognition. The incidence is probably much higher because many fractures go undiagnosed as a wrist "sprain" or type I epiphyseal injury of the distal radius and ulna. An outcome study of carpal injuries at the Children's Hospital of Eastern Ontario, a regional pediatric trauma center, disclosed 15 children who had sustained a triquetral fracture. Three were initially missed, and most were flake fractures. An average follow-up of 4 years showed only two patients with complaints of wrist stiffness and discomfort with hyperextension of the wrist. The increased ligamentous laxity of the wrist in children may actually predispose to triquetral injury by causing ulnar impingement of the triquetrum with ulnar deviation and extension of the wrist. Pain in a child's wrist just distal to the ulna, the "triquetral point," should arouse suspicion of a fracture of the triquetrum.

Adolescent↗