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Biomedical subjects

D Etherington

Publications and source records attributed to D Etherington.

3 recordsLinked to original sources
PubMed2000

Basal cell carcinoma and risk of subsequent malignancies: A cancer registry-based study in southwest England.

BACKGROUND: A possible link between basal cell carcinoma (BCC) and an increased subsequent risk of experiencing further noncutaneous malignancies has been suggested in previous cancer-registry and cohort studies. OBJECTIVE: The purpose of this study was to establish whether a possible link between BCC and subsequent malignancies could be confirmed in a new population in which environmental and genetic risk factors may vary from previously studied populations. METHODS: A cohort of 13,961 cancer registry-listed persons from the southwest of England, in whom BCC had been diagnosed during the period of 1981 to 1988, was examined for the relative risk of experiencing various further malignancies. RESULTS: An approximately 3-fold increase in the risk for malignant melanoma was demonstrated. No other cancers occurred in statistically significant excess. CONCLUSION: The previous reported associations of BCC onset with subsequent increased risk for various noncutaneous cancers are not supported by this study.

Adult↗
PubMed1997

Head and neck cancer in the South West of England: influence of socio-economic status on incidence and second primary tumours.

This study examined possible links between the incidence of head and neck squamous cell carcinoma (HNSCC) and social deprivation. Data on all HNSCC registered between 1985 and 1991 in the South West of England were collected. Excluding tumours of the lip and skin there were 1570 cases, 72% in males. Of these, 1467 were identified as first primary tumours. Corrected chi-squared tests, accepting significance at the 5% level, were used to examine the association of socio-economic status (Carstairs index) with incidence at different sites. Overall, the incidence of HNSCC was higher in the socially deprived group. In males, the most deprived group had a significantly higher incidence of oral carcinoma than all other groups (P<0.05), whereas the incidence of laryngeal carcinoma showed a gradual rise with increasing deprivation. In females, where numbers were relatively low, the trend remained, but was less clear. In total, seventy-two (4.9%) cases went on to develop a second primary, of which 35% were in the lung and 13% in the bladder. Socio-economic status did not affect the development of a second primary tumour. The association of HNSCC with carcinoma of the bladder is a new finding.

Adult↗