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Biomedical subjects

D Eustace

Publications and source records attributed to D Eustace.

5 recordsLinked to original sources
PubMed1996

Evolution of sonographic findings in a fetus with agenesis of the urethra, vagina, and rectum.

In a 12-week gestation fetus, routine ultrasound examination suggested dilated loops of bowel. Repeat scans at 13 and 15 weeks showed normal growth but persistence of bowel dilatation. At 20 weeks there was megacystis, hyperechogenic bowel, ascites, and oligohydramnios. The diagnosis of cloacal abnormality was suspected and the parents chose to have pregnancy termination. Post-mortem examination demonstrated female pseudohermaphroditism with agenesis of the urethra, vagina, and rectum.

Adolescent↗
PubMed1993

Interleukin-6 (IL-6) functions as an autocrine growth factor in cervical carcinomas in vitro.

Many factors have been implicated in the etiology of cervical neoplasia, with human papilloma virus being the latest in a long line of agents that may on their own or in combination exert various initiating and promoting effects on cervical cells, resulting in their transformation. However, for such altered cells to become invasive, it is clear that they must undergo alterations in their rate of turnover, state of differentiation, and motility. We have investigated the production of the multifunctional cytokine interleukin-6 (IL-6) by five new cervical carcinoma cell lines (XH1, EH2, DE3, JE6, and SM7) and the commercially available CaSki cell line, and have studied the effects of this cytokine on the growth of the cells in vitro. All the cell lines produce biologically active IL-6 in amounts varying between 0.35 to 2.0 ng/ml. In the presence of goat anti-sera to IL-6 all the tumor cell lines showed inhibition of growth. IL-6 acts as an autocrine growth factor for in vitro cervical tumor cell growth.

Carcinoma↗
PubMedDate not supplied

Spontaneous spinal extradural hematoma during pregnancy.

BACKGROUND: Spontaneous spinal hematomas are rare in pregnancy, and only two cases have previously been described. This report reviews other similar cases and discusses the aetiology and management of this condition in relation to pregnancy. CASE: A 26-year-old primigravida presented at 35 weeks of gestation with a history of sudden onset of back pain and weakness with loss of sensation of her legs. On examination there was tenderness over the seventh thoracic vertebra with loss of sensation below the level of the T7 dermatome and reduced power in both lower limbs. Magnetic resonance imaging demonstrated an anterior extradural lesion in the mid-thoracic region of the spinal cord. An elective cesarean section was performed followed by a costotransversectomy and removal of an extradural hematoma. The patient's neurological function subsequently improved. CONCLUSION: Acute spontaneous spinal extradural hematoma occurring during pregnancy can be associated with successful outcome following prompt diagnosis and surgical treatment.

Adult↗