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Biomedical subjects

D F Barrett

Publications and source records attributed to D F Barrett.

7 recordsLinked to original sources
PubMed1989

Tissue oxygenation, venous ulcers and fibrin cuffs.

Skin oxygen tension (TcPO2) was measured at 43 degrees C on patients (n = 27) with venous ulcers. Measurements were made at ulcer edge and proximally on the same limb for control. Similar measurements were also made on healthy volunteers (n = 14) in the medial aspects of the distal third of the legs. TcPO2 at ulcer edge was significantly lower (P = 0.001) than control values which in turn were lower than that measured on healthy volunteers. TcPO2 reflects skin nutrition. While low TcPO2 at ulcer edges might be the result of pericapillary barriers to oxygen transport, the control values measured on apparently normal skin suggest the need for further studies.

Adult↗
PubMedDate not supplied

Methylprednisolone pulses and urine electrolyte excretion.

The mineralocorticoid activity of methylprednisolone pulses was assessed by measurement of urine electrolyte excretion prior to and during alternate day pulsing in patients with skin or joint disease. Two groups were studied: the first receiving pulses, but no other steroid; the second having taken oral prednisolone prior to and during pulsing. Urine sodium excretion in 24 hr urine specimens from both groups was suppressed, with no rebound between pulses, but a gradual "escape" occurred from the effects of continued pulsing. Four hour urine collections demonstrated suppression of urinary sodium excretion for up to 32 hr after pulsing with gradual recovery. The peak recovery in sodium excretion coincided with the subsequent pulse and was insufficient to compensate for the preceding sodium retention. Alternate day pulsing does not, therefore, reduce the risk of sodium retention from large doses of methylprednisolone.

Electrolytes↗