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Biomedical subjects

D F Biggs

Publications and source records attributed to D F Biggs.

At least 55 records · Page 3Linked to original sources
PubMed1979

In vitro binding and pharmacokinetics of gold salts in plasma proteins and chelating agents.

The binding of sodium aurothiomalate, sodium aurothiosulphate and aurothioglucose to plasma proteins has been investigated in vitro. All gold compounds were bound to protein at a similar rate and had similar apparent affinity constants and binding capacities. Penicillamine (10 or 100 microgram/ml) was unable to chelate significant amounts of bound gold from plasma protein.

Aurothioglucose↗
PubMed1976

Monoquaternary neuromuscular blocking agents based on 1-tetralone and 1-indanone.

The preparation of three isomeric 1-tetralone hydrozones 4 and three isomeric 1-indanone hydrozones 5 possessing a single quaternary ammonium center is described. Several of the compounds possessed significant neuromuscular blocking activity, and two approached suxamethonium in potency. 1H NMR evidence obtained from a study of the N,N-dimethylhydrozones indicated that the hydrazones adopted an E configuration in solution.

Animals↗
PubMed1975

Toxicology and pharmacological action of anabaena flos-aquae toxin.

Calves, rats, ducks, and goldfish given lethal oral doses of bacteria-free lyophilized cell suspensions of toxic Anabaena flos-aquae died as a result of respiratory arrest. Experiments with selected animals and pharmacological preparations showed that the main effect of the toxin was production of a sustained postsynaptic depolarizing neuromuscular blockade.

Administration, Oral↗
PubMed1975

Quantitation of gold in skin in chrysiasis.

Skin, plasma, hair, and nail gold levels were determined in three groups of patients with rheumatoid arthritis comprising: I. Three patients on long term gold therapy exhibiting altered skin pigmentation (chrysiasis); II. Five patients on long term gold therapy exhibiting normal skin pigmentation; III. Two patients starting gold therapy. Group I had higher skin gold levels (50-140 mug/g) than Group II (7.5-13 mug/g) while Group II had minimal levels. Hair and nail gold levels were not much higher than gold levels in non-gold treated individuals. The possible role of skin in the storage or excretion of gold is discussed.

Arthritis, Rheumatoid↗