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Biomedical subjects

D F Cohen

Publications and source records attributed to D F Cohen.

5 recordsLinked to original sources
PubMed1982

Transient neonatal hyperammonaemia. A case report.

A case of transient neonatal hyperammonaemia (TNH) is described. The entity of TNH has only recently been identified and awareness of the condition may reveal that it is, in fact, not exceedingly rare in premature infants. The presentation of TNH mimics the neurological damage associated with asphyxia, sepsis or intraventricular haemorrhage, all of which occur frequently in premature infants. However, while the latter conditions are associated with a poor prognosis, the outcome for infants with TNH appears to be favourable if aggressive treatment is instituted at an early stage. Treatment consists of dialysis and/or exchange transfusion. A brief review of the literature on TNH is included.

Ammonia↗
PubMed1982

Maternal-infant vitamin D relationships during breast-feeding.

To evaluate the effect of maternal dietary vitamin D intake on infant vitamin D status in a country with a temperate climate, but where the commercial milk supply is not vitamin D fortified, this randomized, double-blind study was conducted on term mother-infant pairs during the winter months. Well-nourished, white nursing mothers were given a placebo, 500 IU vitamin D/day or 1,000 IU vitamin D/day; their infants were not given supplemental vitamin D. After six weeks, mothers receiving supplemental vitamin D had higher levels of 25-hydroxyvitamin D than had mothers receiving placebo. A direct relationship was observed between maternal and infant levels of 25-hydroxyvitamin D at six weeks, implying that maternal vitamin D intake directly affects the vitamin D concentration in breast milk. A control group of infants who had received 400 IU vitamin D/day had even higher concentrations of 25-hydroxyvitamin D, suggesting that infant supplementation with vitamin D is more efficacious than maternal supplementation. Despite the favorable climate in South Africa, during winter breast-fed infants have low serum vitamin D values if maternal dietary vitamin D intake is low.

Alkaline Phosphatase↗
PubMed1980

Skeletal findings in human neutrolethyrism. Is there a human osteolathyrism?

In a review of the roentgenological files of 22 patients suffering from spastic paraplegia due to neurolathyrism, 3 patients were found to present abnormal skeletal findings. 2 patients showed absence of union of the secondary ossification centres of the iliac crests, the ischial tuberosities and the vertebral bodies. Their age at the time of ingestion of poisonous Lathyrus sativus plants was 19 and 20 years. The 3rd patient had bowing and thickening of his right femoral shaft. He was 22 years old at the time of poisoning. These findings which are similar to those found in experimental osteolathyrism have never been described in clinical neurolathyrism. They are of a nature to throw some doubt on the correctness of the currently prevailing concept of sharp distinction between these two pathological entities.

Bone Diseases↗