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D F Graft

Publications and source records attributed to D F Graft.

24 records · Page 2Linked to original sources
PubMed1984

A prospective study of the natural history of large local reactions after Hymenoptera stings in children.

Large local reactions are a frequent occurrence after insect stings. We prospectively studied the demography, immunology, and significance of these reactions in the pediatric age group. Most children (83%) who have had large local reactions have positive skin test results to one or more venoms. Elevated amounts of venom-specific IgE antibody are usually present. Over 3 to 5 years, allergic sensitivity declines, as evidenced by less positive skin test results and lower levels of antivenom IgE antibodies. Most significantly, of 113 repeat stings, only 2% resulted in a systemic reaction.

Adolescent↗
PubMed1982

Granulocyte chemiluminescence in adolescent patients with cystic fibrosis.

The granulocyte chemiluminescence (CL) response is the result of activating its cellular "respiratory burst" and oxidative metabolism. The resulting light emission is an indication of intact metabolic events important in bactericidal activity. Patients with cystic fibrosis have recurrent pulmonary infections. To determine whether granulocytes from patients with CF have defective oxidative metabolism, CL was assayed in 8 patients and compared with that in normal control subjects. In CF, the peak CL response to opsonized zymosan is normal. If, however, the time required for peak light emission is compared with the NIH Clinical Score, a significant correlation is found. Granulocytes from patients with airway disease and more severe CF have a more rapid onset of the CL response. Although the clinical significance of this observation is not established, granulocytes from patients with CF appeared "primed" in their responses to a phagocytic stimulus.

Adolescent↗
PubMedDate not supplied

Venom immunotherapy: when to start, when to stop.

Over the past 25 years, major advances have been made in the diagnosis and treatment of insect sting allergy. Controlled clinical trials have demonstrated the efficacy of venom immunotherapy (VIT) in the prevention of subsequent systemic reactions in allergic individuals. We have refined our criteria for selection of patients for VIT. Studies on selections of venoms, rush immunotherapy, and interval between VIT injections have been performed. Finally, much work has been done to try to define criteria for the discontinuation of VIT.

Adolescent↗
PubMedDate not supplied

Venom immunotherapy during pregnancy.

A patient who received venom immunotherapy during pregnancy without complications delivered a healthy term infant. Venom-specific IgG antibodies were similar in the mother and infant at birth and then fell to undetectable levels by six months of age. Although the mother had elevated venom-specific IgE levels, they were not detectable in the infant at birth or six months of age. Therefore, venom immunotherapy during pregnancy did not lead to allergic sensitization of this child.

Adult↗