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Biomedical subjects

D F Harrison

Publications and source records attributed to D F Harrison.

17 recordsLinked to original sources
PubMed1979

Surgical management of hypopharyngeal cancer. Particular reference to the gastric "pull-up" operation.

Between the years 1965 to 1977, 58 patients with advanced hypopharyngeal squamous carcinoma were treated by pharyngolaryngoesophagectomy and total thyroidectomy. Operative mortality for potentially curable cases was 8.6%, with a crude three-year survival rate of 29% for all cases. Mortality was 37% for patients with postcricoid tumors. Long-term management was uncomplicated except for calcium metabolism; two patients died from nephrocalcinosis secondary to return of circulating parathyroid hormone. I discuss the role of this operation in the successful treatment of hypopharyngeal cancer.

Adult↗
PubMed1979

Intrinsic weakness of the TNM system for classification of laryngeal cancer.

All tumor classifications are compromises based upon clinical or radiological evaluation with little concern for histology and intrinsic errors in application. Laryngeal cancer is no exception, and the present UICC system is critically examined with the intention of highlighting such deficiencies and relating them where possible to prognosis. Possible lymph node and systemic metastases are also considered in the light of personal experience and any intrinsic weaknesses evaluated in relation to variations in published cure rates. No better system is proposed, for at least this system encourages more accurate recording of clinical assessment.

Carcinoma, Squamous Cell↗
PubMed1978

Rehabilitation problems after pharyngogastric anastomosis.

Fifty-three patients had pharyngolaryngoesophagectomy during the years 1965 to 1976 for lower hypopharyngeal or cervical esophageal cancer. The operative mortality--defined as the percent of patients who died within seven days of operation--was 7.5%, which is reduced to 5.6% if one patient with inoperable disease is excluded. Twenty-eight percent of patients survived for longer than one year, and there have been no problems with swallowing. Communication is possible in every patient who possesses good motivation, but the problems of long-term management of calcium metabolism still require attention.

Calcium↗
PubMed1977

Saccular mucocele and laryngeal cancer.

Saccular mucoceles are a definite entity and probably occur more frequently than is supposed. Confusion with internal laryngoceles is possibly due to lack of understanding of basic anatomy and physiology. A 49-year-old man had a saccular mucocele that was possibly associated with laryngeal cancer, although a definitive diagnosis was only made two years later. The laryngectomy specimen was serially sectioned and showed an internal laryngocele on the side that was not operated one. This patient remains alive and well four years after excision of a T4 carcinoma, although a unilateral radical neck dissection was performed two years ago.

Animals↗
PubMed1977

Resection of the manubrium.

Direct exposure of the superior mediastinum is essential when resecting subglottic tumours of the larynx, neoplasms of the cervical trachea or cervical oesophagus. This facilitates low resection of the trachea and clearance of the paratracheal nodes. This may best be carried out by removal of most of the manubrium sterni and both sternoclavicular joints and this operation has been performed in 22 patients with minimal morbidity or long term disability.

Esophageal Neoplasms↗
PubMed1975

Tonsillectomy.

Explore the source record for details and available documents.

Child↗
PubMedDate not supplied

Critical look at the classification of maxillary sinus carcinomata.

All the classification systems at present adopted for use in carcinoma of the maxillary sinus suffer from both intrinsic inaccuracies and an apparent failure to relate T (extent of primary tumor) categories to clinical experience of the spread of these tumors. Three systems are critically analyzed in relation to personal experience of 86 patients with sinus carcinoma and a fourth system proposed as a compromise solution to this problem.

Humans↗
PubMedDate not supplied

A long-term comparative study of the mammalian larynx, based on whole organ serial sectioning.

The paper includes brief details of a long term three-dimensional study into the fine structure of the mammalian larynx using whole organ serial sections. Differential staining, including Glees silver technique, is essential if maximum information is to be gained. A specially designed punch card will enable any future investigator to rapidly retrieve relevant information and it is expected that specimens of all available mammalian larynges will be included. Illustrations are included in this paper of the cat, dog, horse and mongoose.

Animals↗