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Biomedical subjects

D F McCoy

Publications and source records attributed to D F McCoy.

15 recordsLinked to original sources
PubMed1990

Conditioning of morphine-induced taste aversion and analgesia.

The process of selective associations is evident in the aversive conditioning literature, where it has been shown that external cues are readily associated with peripheral pain, whereas taste cues are more easily associated with effects of drug administration. Within this framework, it is of interest that the failures to obtain a conditioned analgesic response to a morphine-associated CS have used external cues as conditioned stimuli. In Experiment 1, subjects re-exposed to a morphine-associated CS not only expressed the anticipated taste aversion, but also exhibited a decrease in pain sensitivity that was evident 15 or 30 min following CS re-exposure. Experiment 2 suggested that the conditioned analgesic response was opioid mediated, as pre-test administration of naloxone blocked expression of the analgesic CR. In Experiment 3, an increase in opiate receptor sensitivity produced by chronic naltrexone treatment did not affect the strength of the taste aversion, but resulted in an increase in the magnitude of the conditioned analgesic response. Collectively, these data suggest a neuropharmacological dissociation in systems mediating the two responses.

Analgesia↗
PubMed1986

Some parameters of conditioned immunosuppression: species difference and CS-US delay.

Three experiments were conducted in which an illness-inducing immunosuppressant, cyclophosphamide (an unconditioned stimulus, US) was associated with a previously presented saccharin solution conditioned stimulus (CS). In each experiment, reexposure to the CS produced a conditioned suppression of the plaque-forming-cell response in the experimental groups. Experiment I demonstrated this result with Fisher 344 rats. Experiment II replicated the effect with Balb/c mice. In Experiment III conditioned immunosuppression was demonstrated when mice received CS-US delays as long as 6 hours. No evidence of a delay gradient was present in either the behavioral or the immunologic data. These parallel findings offer no support for the idea of a dissociation between the taste aversion and conditioned immunosuppression processes.

Analysis of Variance↗
PubMed1983

The role of elicited responding in the feature-positive effect.

Hearst and Jenkins proposed in 1974 that elicited responding accounts for the feature-positive effect. To test this position, pigeons were exposed to a feature-positive or feature-negative discrimination between successively presented displays--one consisted of a red and a green response key and the other consisted of two green response keys. There were four main conditions: 5-5 (5-sec trials, 5-sec intertrial intervals), 5-30, 30-30, and 30-180. Conditions 5-30 and 30-180 should produce the largest amount of elicited responding, and therefore the largest feature-positive effects. A response-independent bird was yoked to each response-dependent bird to allow direct assessment of the amount of elicited responding generated by each condition. Contrary to the predictions by Hearst and Jenkins's theory, response-dependent birds showed large feature-positive effects in each condition. The largest feature-positive effect was obtained in condition 5-5. Response-independent birds produced similar results, but manifested low response rates.

Animals↗
PubMed1981

Effects of stimulus contact on the feature-positive effect.

Fourteen pigeons were taught to discriminate displays differentiated by the presence or absence of a distinctive feature. Feature-positive (FP) birds were reinforced for responses to displays containing the feature, while feature-negative (FN) birds were reinforced for responses to displays containing only the elements common to both stimulus displays. Both control and experimental birds were required to respond to a spatially separate operant key, while experimental animals were also required to contact the individual elements of the display. A planned comparisons test indicated that FP performance was superior to FN performance only for the control animals. No difference was found between the performance of the experimental FP and FN birds. Consideration of the elements of the display toward which the FN birds orient was offered as an explanation of these results.

Animals↗
PubMed1980

Comparison of two techniques for the development and maintenance of tracking behavior in monkeys.

The present study compared two methods by which animal subjects can be taught to perform a pursuit tracking task. Rhesus monkeys were trained to track in order to avoid shock (Method No. 1) or to obtain food (Method No. 2). One animal received training under both procedures. Both techniques were effective; however, the method utilizing shock produced faster learning and more efficient performance. The possible reasons for these differences are discussed along with generality of the results. These methods should have implications for tracking research in which animal models are required.

Animals↗
PubMed1980

Feature-positive and feature-negative learning in the rhesus monkey and pigeon.

In separate experiments four monkeys and eight pigeons were presented with displays containing one red and two green keys and displays containing three green keys. During feature-positive phases, responses to displays containing the one red and two green keys were reinforced on a fixed-ratio schedule, while responses to displays containing the three green keys were never reinforced. During feature-negative phases, only responses to the three green key displays were reinforced. For monkeys in Experiment 1, both between and within subject analyses indicated that the learning of feature-positive discriminations was superior to the learning of feature-negative discriminations. The within subject analysis further revealed that performance on a feature-positive discrimination was retarded following exposure to a feature-negative discrimination, while performance on a feature-negative discrimination was enhanced following exposure to a feature-positive discrimination. Experiment 2 replicated the essential aspects of these reversal effects in four experimental pigeons. Evidence that these reversal effects were not simply a function of time was provided by four control birds exposed to only a feature-positive or feature-negative discrimination.

Animals↗
PubMed1979

Generalization gradients following differential intradimensional autoshaping.

Three pigeons were trained on a differential, intradimensional autoshaped discrimination. A 45 degrees line tilt was always paired with food whereas a 15 degrees line tilt was never paired with food. All subjects learned the discrimination within 17 sessions. The pigeons were then given generalization tests in extinction over seven line tilts (0 degrees, 15 degrees, 30 degrees, 45 degrees, 60 degrees, 75 degrees and 90 degrees). The subjects yielded generalization gradients with maxima at 45 degrees and minima at 15 degrees. An area shift, but no peak shift, was found for each subject.

Animals↗
PubMed1979

Positive contrast in the rat: a test of the additivity theory.

Rats were trained to lever press for food on a multiple variable-interval variable-interval schedule, then shifted to a multiple variable-interval extinction schedule. For six subjects (group L), schedule components were signalled by the presence or absence of a flashing light emitted from an alternate, "signal" lever. For four subjects (group T), schedule components were signalled by two distinct auditory tones. Contrary to the predictions of an additivity theory based on the summation of response classes, contacts on the signal lever did not increase after the schedule shift in group L. However, nine of the ten subjects in the study demonstrated positive contrast effects on the operant lever. In a subsequent test for stimulus control, enhancement and suppression by the discriminative stimuli were found in these same nine subjects. An additivity theory based on the summation of excitatory processes, rather than response classes, appears to account for these data.

Animals↗
PubMed1979

Temporal parameters of the feature positive effect.

Trial duration and intertrial interval duration were parametrically varied between groups of pigeons exposed to a discrimination involving the presence vs. the absence of a dot. Half the groups received the dot as the positive stimulus (feature positive groups) and half the groups received the dot as the negative stimulus (feature negative groups). Faster learning by the feature positive birds (feature positive effect) was found when the trial duration was short (5 sec) regardless of whether the intertrial interval was short (5 sec) or long (30 sec). No evidence for a feature positive effect was found when the trial duration was long (30 sec) regardless of the length of the intertrial interval (30 sec or 180 sec). The results suggest that short trial duration is a necessary condition for the occurrence of the feature positive effect, and neither intertrial interval nor trial duration/intertrial interval ratio are important for its occurrence. The suggestion that mechanisms underlying the feature positive effect and autoshaping might be similar was not supported by the present experiment since the trial duration/intertrial interval ration parameter appears to play an important role in autoshaping but not the feature positive effect.

Animals↗
PubMed1969

Stimulus generalization of gravity.

In two experiments, squirrel monkeys were exposed to centrifugally generated, artificial gravity and trained to respond for food reinforcement at selected gravity (g) levels. Experiment I involved a single g value; in Exp. II, subjects were trained to discriminate among two or three g values. After training, generalization tests were administered over a 1.1-g to 2.1-g range. The major findings were as follows: (a) single-stimulus training yielded a linear relationship between percentage of responding and magnitude of gravity. (b) Two-valued discrimination training produced gradient peaks which were shifted from S(D) in a direction away from S(Delta). This effect was cancelled when S(D) was located equidistant between two S(Delta) stimuli. (c) Gradient form was independent of the S(D)-S(Delta) difference, but related to continuum location and/or intensity of discriminative stimuli.

Animals↗