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Biomedical subjects

D F Mobley

Publications and source records attributed to D F Mobley.

At least 19 recordsLinked to original sources
PubMed1982

Renal vein thrombosis in renal cell carcinoma. Proteinuria as diagnostic sign.

In 4 patients with hypernephroma and extension of the tumor thrombus into the renal vein, there has been a significant degree of proteinuria. We believe that the proteinuria in association with a renal mass suggests a tumor thrombus in the renal vein and warrants the preoperative inferior venacavogram. After a larger number of patients have been studied, it may become clear that patients who do not have proteinuria do not have renal vein or vena caval involvement. If this proves to be the case, these patients may be selectively spared inferior venacavography. For the present time in patients with hypernephroma, we can only recommend that the index of suspicion for renal vein involvement with tumor thrombus should remain high if the patient has significant proteinuria.

Adenocarcinoma↗
PubMed1981

Bacterial prostatitis: treatment with carbenicillin indanyl sodium.

The efficacy and safety of carbenicillin indanyl sodium were evaluated in 16 patients with acute or chronic bacterial prostatitis. Each patient received carbenicillin indanyl sodium (Geocillin) tablets, at a dosage of two 500 mg tablets (each tablet equivalent to 382 mg of carbenicillin) four times daily for either 14 days (acute patients) or 28 days (chronic patients). Clinical and bacteriologic success rates, based upon 4 week post therapy followup, were 93 per cent and 75 per cent respectively. There were no adverse reactions. Results with cephalexin in a concurrently treated alternative therapy group were generally unsatisfactory. Further evaluations of carbenicillin indanyl sodium in this treatment of resistant populations are clearly warranted.

Acute Disease↗
PubMed1977

Immunoglobulin A in split ejaculates of patients with prostatitis.

7S and 11S IgA (immunoglobulin A) levels in split ejaculates of 17 patients with chronic prostatis and 16 normal subjects were studied by the Hanson radial immunogel filtration method. The results suggest at least in certain cases of prostatitis increase of IgA level involves elevation of both types of IgA, and they are mainly of prostatic origin.

Body Fluids↗
PubMed1977

Clinical use of immunoelectrophoresis of split ejaculates. I. Variation of patterns due to antisera.

As a preliminary investigation for the clinical application of immunoelectrophoresis of ejaculate in the diagnosis of male reproductive organ diseases, variations of immunoelectrophoretic patterns in normal subjects due to the difference of antigenicity between split ejaculates were demonstrated with rabbit antisera. Fresh samples and antisera against them gave larger numbers of and more intense precipitin lines than in stored samples. The precipitin lines developed by acid phosphatase were most remarkable between first portion of ejaculate (F1) and anti-F1, whereas the line caused by protein from the seminal vesicle was most prominent between the remainder of the ejaculate following F1 (F2) and anti-F2.

Animals↗
PubMed1977

Studies in ureteral regeneration: replacement of a large segment of ureter with an in situ pedicle graft of proximal ureter.

The phenomenon of ureteral regeneration has been of interest to clinicians, anatomists, and physiologists for many years. The object of this investigation was to study the regeneration of a long pedicle graft of ureter. Regeneration of the pedicle graft over a stent took place in 4 to 5 weeks. At sacrifice 8 to 10 months postoperatively, 7 of 10 operations were completely successful with no evidence of hydronephrosis, obstruction, or pyelonephritis. Two animals exhibited slight dilation of the upper tracts, and one operation was a failure. It is evident from this study that a strip of ureter removed from the ureteral artery will regenerate over a stent in 4 to 5 weeks if the blood supply from the adjacent adventitia is left intact.

Animals↗
PubMed1976

Phenoxybenzamine in the management of neurogenic vesical dysfunction.

The clinical effect of phenoxybenzamine, an alpha blocking agent, was studied in a series of 37 patients with varying degrees of neurogenic vesical dysfunction. An over-all 78 per cent success rate was achieved, with an 86 per cent success rate in patients with reflex neurogenic bladder. Phenoxybenzamine demonstrates excellent results in patients with neurovesical dysnfunction who are unable to empty their bladders by other means. The drug demonstrated effectiveness regardless of the level of the lesion, cystometric findings or duration of neurogenic vesical disease.

Adolescent↗
PubMed1975

Ureteral replacements.

The clinical necessities of replacing all or part of the diseased or destroyed ureter have plagued surgeons for many years. In the past seventy years more than 100 surgical techniques have been described for ureteral replacement. Methods of replacement have fallen into four categories; nonbiologic substitutes, pedicle grafts, free grafts, and implantation and diversion. This review discusses the history and present status, and presents a look to the future in the surgery of ureteral replacement.

Animals↗
PubMed1975

Metastatic carcinoma of prostate masquerading as abdominal aortic aneurysm.

A case is reported in which the patient had classic findings of an abdominal aortic aneurysm, including a pulsatile abdominal mass, curvilinear aortic calcification, and anterolateral deviation of the left ureter. These findings were subsequently demonstrated at surgery to be due to metastatic nodes from prostatic carcinoma. Data presented indicate that further diagnostic studies may be in order in unusual cases in which patients are suspected of having abdominal aortic aneurysm. This is especially true if the patient is known to have another condition such as carcinoma which may mimic aneurysm with metastatic periaortic lymph nodes. Aortography and/or lymphangiography occasionally have their place in selected patients, and this is discussed.

Adenocarcinoma↗
PubMed1975

Semen cultures in the diagnosis of bacterial prostatitis.

The bacterial flora of semen from normal men has been studied. Positive cultures were obtained in 45 per cent of these individuals but only in smally colony counts of non-pathogenic bacteria. The seminal flora of patients with bacterial prostatitis was then studied. Excellent correlations have been noted between cultures of prostatic secretions and semen. Semen cultures will almost invariably be diagnostic in patients with bacterial prostatis. This technique has definite usefulness in selected patients in whom it is otherwise difficult to establish a diagnosis of bacterial prostatis.

Bacterial Infections↗
PubMed1974

Chronic prostatitis.

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Anti-Bacterial Agents↗