Biomedical subjects

D F Perfil'ev

Publications and source records attributed to D F Perfil'ev.

At least 19 recordsLinked to original sources

PubMed1994

[Microbiological and immunological indicators of local peritonitis of appendiceal origin].

The causative agents of localized peritonitis are certain microbial associations of 2-6 bacterial species including staphylococci, enterococci, Escherichia coli, Proteus, and obligate anaerobes Cl. perfringens. A dominant position is occupied by Escherichia coli and obligate anaerobes in critical doses (105 and more microbial bodies per 1 ml of exudate). In the course of the disease all five types of antibodies accumulated independently of one another, while the intensity of their rise depended on the term of treatment and the patient's age. A twofold and greater increase of the antibody titers may confirm the etiological role of the microbes in peritonitis, whereas the level of their increase may be an indirect criterion of localized peritonitis prognosis.

Acute Disease↗

PubMed1993

[Microbiologic and immunologic parameters in patients with abscesses of the abdominal cavity].

Dynamic bacteriological examination of abdominal exudate and wound pus after operations on 131 patients with abdominal abscesses of various localization revealed a variety of microorganisms among which 44.2% were staphylococci, 22.9% enterococci, 64.1% Escherichia coli, 34.2% proteus microorganisms, 31.0% Cl. perfringens, and 90% nonclostridial anaerobes; certain varieties (phagotypes, serogroups) prevailed among them which possessed pathogenetic properties to a greater measure than their other varieties. A greater part of the cultures obtained from the foci of affection were in various microbial associations (2-6 types) and were resistant to the widely used antibiotics--penicillin, streptomycin, chlortetracycline, and retained their sensitivity to antibiotics of the neomycin series and to other agents. Specific antibodies to the causative agents and the products of their vital activity accumulated (two-sevenfold) during the disease in most patients, and the intensity of their increase depended on the development of purulent complications and the patient's age. The dynamics of changes of the antibody titer may confirm the etiology of the abscess and be an indirect index of the prognosis of the disease.

Abdomen↗

PubMed1992

[Specific immunity in patients with inflammatory diseases of the abdominal cavity].

In most patients with pyoinflammatory diseases of the abdominal cavity caused by Cl. perfringens microbial associations accumulation of agglutinins occurred during the disease. In purulent abdominal processes caused by Cl. perfringens microbial associations a connection exists between the increased antibody level and wound suppuration. The rise of the antibody level was most marked, whatever the character of the bacterial associations, in patients with generalized peritonitis, abdominal abscess, and in young patients (10-40 years of age) and least in those with phlegmonous cholecystitis and in elderly patients (61-70 years of age). Patients with destructive forms of appendicitis and individuals aged 41-60 took an intermediate position according to these values. Antibody production was weaker in patients with 5 species in the microbial association than in monoinfection. A agglutinin titer in the blood of patients beginning with 1:80 and higher should be considered diagnostic.

Abdomen↗

PubMed1990

[Microbiological and immunological indicators in patients with acute cholecystitis].

The causative agents of acute destructive cholecystitis and wound complications are various pyogenic bacteria including staphylococci, enterococci, Escherichia, Proteus, and anaerobes among which certain varieties, serogroups, and phagocytes predominate. Most bacteria, with the exception of anaerobes, are resistant to penicillin, streptomycin, and chlortetracycline but retain sensitivity to antibiotics of the neomycin series and other chemotherapeutic agents. In most patients with phlegmonous cholecystitis specific antibodies accumulated in the blood during the disease irrespective of one another, while the intensity of their increase was determined by the duration of treatment and the patients' age. The dynamics of changes of the specific antibody titres may confirm the etiology of cholecystitis and be an indirect sign of the prognosis of the disease.

Acute Disease↗

PubMed1987