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Biomedical subjects

D F Senior

Publications and source records attributed to D F Senior.

23 records · Page 2Linked to original sources
PubMed1980

Capillaria plica infection in dogs.

The prevalence, pathologic effects, and treatment of Capillaria plica infection were investigated in two breeding kennels. The prevalence of C plica infection in mature dogs in two kennels (127 dogs) was 76% and 59%. Pups less than 8 months old did not pass C plica eggs in the urine. Age, breed, or sex predilection was not observed in mature dogs. In infected dogs, hematuria, dysuria, and pollakiuria developed without secondary bacterial cystitis. A direct life cycle could not be demonstrated experimentally. Histologically, adult C plica were seen in the submucosa of the bladder and ureter, where they induced a mild inflammatory reaction and submucosal edema.

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PubMedDate not supplied

Percutaneous nephrolithotomy in the dog. An experimental study.

Percutaneous nephrostomies (PN) were created with teflon fascial dilators under fluoroscopic guidance, to implant stones bilaterally into the renal pelves of five dogs weighing 7 to 35 kg. Between one and seven stones of 0.25 to 1.00 cm diameter were implanted into each renal pelvis. Two to 4 weeks later, PN tracts were recreated, and the implanted renal stones were successfully removed under fluoroscopic and endoscopic visualization. Results of gross and histopathologic evaluation of the kidneys 2, 7, 14, 30, and 90 days after stone removal showed minimal, localized renal parenchymal trauma. Complications, although infrequent, included proximal ureteral tears and hemorrhage. Difficulty was encountered in maneuvering equipment around large or numerous stones. Canine percutaneous nephrolithotomy was successful despite great variation in kidney size, as well as variations in the number, size, and shape of stones in the upper urinary tract.

Animals↗
PubMedDate not supplied

Use of ursodeoxycholic acids in a dog with chronic hepatitis: effects on serum hepatic tests and endogenous bile acid composition.

A dog with severe cholestasis secondary to chronic hepatitis was treated with ursodeoxycholic acid (UDCA) PO. After 2 weeks of daily treatment, the dog was more active and had an improved appetite. Monthly serum biochemical determinations and analysis of individual bile acid profiles documented improvement in hepatobiliary tests and a marked reduction in the concentrations of potentially hepatotoxic endogenous bile acids. These effects were maintained for approximately 6 months. The findings in this dog are similar to those reported for human patients treated with UDCA and provide preliminary evidence in support of its continued evaluation in the treatment of cholestatic liver disease in the dog.

Animals↗