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Biomedical subjects

D Ferguson

Publications and source records attributed to D Ferguson.

At least 127 records · Page 7Linked to original sources
PubMed1981

Aged abuse.

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Aged↗
PubMed1981

Chronic ambulatory liver support by membrane plasmapheresis with on-line detoxification.

Blood cellular elements and plasma protein losses are minimal for membrane plasmapheresis with on-line sorbent detoxification. Frequent (6/sk), chronic (3 mos), and long-term (8 hr) perfusions are possible for patients studied. It is recommended in deficiency states involving low protein, hypocoagulability or potential hormonal imbalances that aggressive medical management be applied. With regard to system performance, plasma filtration properties improved by the application of the closed plasma circuit and membranes with superior sieving and filtration properties. The effect of plasma solutes on filtration properties has been noted. In PBC patients the influence of total cholesterol concentration is particularly striking. Significant reduction of FFA and improvement of PMR were achieved in combination with bilirubin removal in liver failure patients, while bile acids (cholyglycine) levels were significantly reduced in 3 of PBC patients who expressed a subjective improvement of about 90% following 3 consecutive treatments. Four of 5 liver failure patients showed improved mental status with one patient surviving.

Adult↗
PubMed1977

Angiotensinase activity and angiotensin receptor binding in guinea pig aorta.

The angiotensinase (EC 3.4.99.3) activity of the subcellular fractions of guinea pig aorta has been studied in relation to their [14C]angiotensin binding capacity. The enzyme activity occurs in the following decreasing order: supernatant greater than plasma membrane fraction greater than 105 000 X g pellet greater than mitochondrial fraction. The specific binding of [14C]angiotensin to these fractions follows the same pattern. Pretreatment of the subcellular fractions at 47 degrees C for 20 min was performed in an attempt to differentiate binding of angiotensin to the pharmacological receptor from binding to the destroying enzymes. This procedure decreased the angiotensinase activity in the plasma membrane fraction only whereas the specific binding of [14C]angiotensin to this fraction was not significantly decreased, suggesting that the plasma membrane angiotensinase is a thermolabile enzyme.

Angiotensin II↗
PubMed1976

The right pulmonary artery-left atrial axis line. A method for measuring left atrial size on lateral chest radiographs.

Based on the relationships of the aorta, right pulmonary artery (RPA), and left atrium (LA), a method for directly measuring the LA diameter is described. A line drawn downward from the anterior wall of the RPA, parallel to the barium-filled esophagus, will approximate the anterior wall of the LA and enable a direct measurement of the anteroposterior LA diameter. This radiological measurement correlated well with the echocardiographic determination of LA size in 82 adult patients. In some patients, direct measurement of LA size made it possible to detect chamber enlargement before other signs appeared. The major disadvantage of this method is the inability to clearly see the RPA in infants and in approximately 10-15% of adults.

Cardiomegaly↗