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Biomedical subjects

D Forbes

Publications and source records attributed to D Forbes.

At least 37 records · Page 2Linked to original sources
PubMed1997

Racial and ethnic differences in determinants of intrauterine growth retardation and other compromised birth outcomes.

OBJECTIVES: This study examined the extent of variation by race/ethnicity in the prevalence of adverse birth outcomes, whether differentials persisted after other risk factors were controlled for, and whether the direction and magnitude of relationships differed by type of outcome. METHODS: A revised system of measurement was used to estimate multinomial logistic models in a large, nationally representative US data set. RESULTS: Considerable racial/ethnic variation was found across birth outcome categories; differences persisted in the adjusted parameter estimates; and the effects of other risk factors on birth outcomes were similar as to direction, but varied somewhat in magnitude. The odds of compromised birth outcomes were much higher among African Americans than among Mexican Americans and non-Hispanic Whites. CONCLUSIONS: In addition to persistent racial inequality, we found strong adverse effects of both inadequate and "adequate-plus" prenatal care and smoking. Risk of intrauterine growth retardation was higher in the absence of medical insurance, and risk of all adverse birth outcomes was lower among mothers participating in the Special Supplemental Food Program for Women, Infants, and Children.

Adolescent↗
PubMed1997

The effect of mandibular rotation on molar position.

The findings of this experiment revealed important associations among dental and skeletal parameters in differing degrees of mandibular rotation. The structural elements of the craniofacial complex vary in size, morphologic pattern and their spatial relationship dictate the relationship of the dental arches. The results of these comparisons support the assumption that variations in the mandibular plane angle are also accompanied by a significant difference in the craniofacial relations. 1. The degree of mandibular rotation is not significantly associated with the dental classification in any group or the total sample. 2. Significant correlations were determined for the dental classification and the horizontal skeletal measurements of ANB, Wits, and Harvold at the 0.05 confidence level. Therefore, the skeletal pattern accurately reflects the underlying dental relationship. 3. Ratios differed in the various categories when compared to the total population with increased correlations noted for some groups. The average FMA group showed the least variability of all the categories since the range was the smallest (25-30 degrees). 4. Although skeletal parameters are often highly correlated, their association may prove to be contradictory in patients with severe skeletal disharmonies.

Cephalometry↗
PubMed1996

Compromised birth outcomes and infant mortality among racial and ethnic groups.

Research based on hospital records demonstrates that many births classified as normal according to conventional demographic measurement are intrauterine growth-retarded (IUGR) when evaluated clinically; also, in addition to birth weight and gestational age, it is necessary to focus on a third dimension, maturity, in analyses of birth outcomes. Although clinical studies allow more precise classification, the small number of cases tends to result in unreliable estimates of rates and in loss of generalizability. The fetal growth ratio, a measure recently shown to be a valid proxy for maturity, is used here to develop a classification system based on combinations of weight, gestational age, and maturity, which we apply in a comparative analysis of a large data set. The results show large differences in the distribution of compromised births across racial and ethnic groups, as well as significant race/ethnic differentials in the risk of infant mortality associated with adverse outcomes.

Adolescent↗
PubMed1995

Differential diagnosis of cyclic vomiting syndrome.

Vomiting is a nonspecific symptom and cyclic vomiting is a symptom complex that may result from a disorder of any major organ system. Children with cyclic vomiting syndrome (CVS) need careful review and investigation at their earliest presentations to exclude potentially lethal abnormalities such as intestinal volvulus, metabolic disorders, and neurologic space-occupying lesions. The range of abnormalities that may present with features consistent with CVS includes gastrointestinal obstructive, inflammatory and motility abnormalities, pancreatic disease, metabolic disease (particularly the amino acid-opathies, organic acidurias, fatty acid oxidation defects, and acute intermittent porphyria), renal disease, epilepsy, migraine, and psychiatric disorders. Careful history taking will usually provide clues to these uncommon problems, but all children should undergo baseline assessment of gastrointestinal morphology and screening tests for renal and metabolic disease.

Child↗
PubMed1995

Prophylactic therapy in cyclic vomiting syndrome.

The experience with prophylactic therapy for cyclic vomiting syndrome (CVS) at Princess Margaret Hospital for Children, Perth, Western Australia was retrospectively reviewed by questionnaire. Data was collected from 31 patients, aged 2.9-21.75 years who reported a mean of nine attacks per year. Eleven patients had utilized prophylactic therapy. Parental assessment of benefit was recorded. Propranolol was the most effective agent with reported benefit in four of six cases, other antimigraine agents were deemed effective in two of seven cases. Anti-convulsants and antidepressants were not considered useful. Homeopathic and vitamin supplements were thought to be beneficial in three of six cases. Prophylaxis was less likely to be beneficial in the more severe cases of CVS, but was of benefit in those patients whose attacks were precipitated by infection or who had features consistent with migraine. Prophylactic therapy with propranolol or serotonin receptor antagonists should be considered in children with frequent or severe symptoms.

Adolescent↗
PubMed1995

Ultraviolet radiation activates the human elastin promoter in transgenic mice: a novel in vivo and in vitro model of cutaneous photoaging.

The major alteration in photoaged skin is the deposition of massive amounts of abnormal elastic material, termed solar elastosis. In previous work, it has been shown that solar elastosis is accompanied by increased abundance of elastin and fibrillin mRNAs and upregulation of elastin promoter activity. Using a transgenic mouse line, which expresses the human elastin promoter, linked to a chloramphenicol acetyltransferase reporter gene, in a tissue-specific and developmentally regulated manner, we investigated the effects of ultraviolet A radiation and ultraviolet B radiation on human elastin promoter activity in vivo and in vitro. Irradiation of mice with a single dose of ultraviolet B radiation (491.4 mJ/cm2) resulted in an increase up to 8.5-fold in promoter activity, whereas a more modest increase of 1.8-fold was measured with ultraviolet A radiation (38.2 J/cm2). In addition, in vitro studies revealed over a thirtyfold increase in elastin promoter activity in response to ultraviolet B radiation (5.5 mJ/cm2), whereas no change was measured in response to ultraviolet A radiation (2.2 J/cm2). These results confirm the role of ultraviolet B radiation in elastin promoter activation in photoaging, and identify ultraviolet A radiation as a contributing factor. This system should serve as a useful in vivo and in vitro model to study cutaneous photoaging, and for testing compounds that may protect against cutaneous photodamage.

Animals↗
PubMed1995

Cyclical vomiting syndrome.

Cyclical vomiting syndrome is an uncommon, disabling symptom complex of unknown cause, with features in common with migraine. It affects principally children and adolescents. Differential diagnosis and theories of pathogenesis are discussed. Therapy should be aimed at prophylaxis of vomiting bouts, 'switching off' episodes once they commence and preventing complications of established vomiting episodes. Families need rapid access to care to minimize morbidity and disruption to functioning.

Adolescent↗
PubMed1994

Eye movement desensitization and reprocessing in posttraumatic stress disorder: a pilot study using assessment measures.

Spectacular claims have been made regarding the efficacy of eye movement desensitization and reprocessing (EMDR) in the treatment of posttraumatic stress disorder (PTSD), but almost entirely on the basis of patients' reports and without objective criteria. This study reports on the treatment of eight patients with a diagnosis of PTSD who received EMDR treatment over four sessions. Assessment measures included two structured interviews, three self-report inventories, and the electromyogram (EMG). Assessments were conducted pre and posttreatment, and at 3-month follow-up. Despite some residual pathology at posttreatment and follow-up, significant improvements were obtained on all measures and across all PTSD symptom clusters. Compared with other treatments of PTSD, change was achieved in far fewer sessions.

Adaptation, Psychological↗
PubMed1994

Abdominal pain in childhood.

An interplay of factors is involved in the problem of recurrent abdominal pain. An adequate history and a sympathetic and supportive approach to both the patient and their family are important as is encouragement to avoid illness behaviour. A number of important organic causes need also to be borne in mind.

Abdominal Pain↗
PubMed1992

Cryptosporidium in 100 Australian children.

Over a consecutive 36 month period, 100 patients out of 6,980 (1.4%) from whom stool samples were examined had oocysts of Cryptosporidium detected on fecal microscopy. Three patients were receiving cytotoxic chemotherapy and adequate clinical information was available from 84 of the remainder. Fifty per cent of patients were aged 1 to 2 years, 29% were less than 12 months and the rest were more than 2 years of age. More than one-quarter of the patients were Australian Aborigines. Isolations of cryptosporidia were most prevalent in late summer, autumn and early winter. Most patients (89%) had diarrhea, more than 75% had vomiting and 44% were dehydrated, mostly to a mild degree. Other symptoms included fever (11%) and abdominal pain (11%). Ten percent of patients were apparently symptomless. Cryptosporidium sp. is the second most commonly identified intestinal parasite, after Giardia intestinalis, in fecal specimens examined in our children's hospital. The high rate of isolation in Aboriginal children emphasized the importance of enteric pathogens in this group and the role of inadequate hygiene in relation to diarrheal disease in young Aborigines.

Child Nutrition Disorders↗
PubMed1991

Spanish surname and Anglo infant mortality: differentials over a half-century.

Using a half-century of death records from San Antonio/Bexar County, Texas, we examine the timing and cause structure of Spanish surname and Anglo infant mortality. Our findings show that despite the substantial disparities between ethnic-specific infant mortality rates in the early years of the study, there have been consistent declines in overall, neonatal, and postneonatal mortality for both groups, as well as a major convergence of mortality rates between Spanish surname and Anglo infants. Further, we demonstrate that the convergence is of relatively recent origin and is due primarily to shifts in postneonatal mortality. Finally, we examine the transition reflected in the cause structure of ethnic-specific infant mortality and show that the convergence was largely the result of reductions in deaths from exogenous causes. Implications for research into the "epidemiologic paradox" are discussed.

Colitis↗