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Biomedical subjects

D Front

Publications and source records attributed to D Front.

At least 109 records · Page 6Linked to original sources
PubMed1981

Correlation between radionuclides uptake and ultrastructural features of tight junctions in the capillary wall of meningiomas.

The uptake of Tc-99m pertechnetate and Co-57 bleomycin and the ultrastructure of small blood vessels were studied in 10 cases of meningioma. When thin sections of 120 contact areas between adjacent endothelial cells were examined, 92% of the intercellular contacts contained one to three punctate tight junctions. Freeze fracture preparations revealed fascia occludens with one to four sealing strands. These findings are consistent with the high permeability the meningiomas displayed for both of the radiopharmaceuticals.

Capillaries↗
PubMed1981

Hydatid disease: the value of whole-body screening by scintigraphy with technetium-99m-labelled red blood cells.

Whole-body scintigraphy with 99Tcm-labelled red blood cells was performed in eight patients with hydatid disease. There was good correlation between these studies and other diagnostic procedures which included radiocolloid liver scintigraphy, liver ultrasound, body computed tomography and chest radiography. Whole-body scintigraphy with 99Tcm-labelled red blood cells appears suitable for screening patients with hydatid disease, many of whom have multiple organ involvement.

Adolescent↗
PubMed1981

Tc-99m-labeled red blood cells in the evaluation of vascular abnormalities.

Scintigraphy with Tc-99m-labeled red blood cells was used to evaluate five patients with suspected vascular abnormalities. The technique was useful for the imaging of large areas of the body and in obtaining multiple views. Conventional radionuclide angiography is of limited usefulness in such cases.

Adult↗
PubMed1979

Bone metastases and bone pain in breast cancer. Are they closely associated?

One hundred ninety patients with breast cancer were prospectively evaluated for bone pain and had technetium Tc 99m-methylene diphosphonate bone scintigraphy for bone metastases. Of the 66 patients showing evidence for bone metastases, 21 (32%) did not have bone pain. There were 155 sites of skeletal metastases, but pain was found only in 50 sites. The age of the patient or involvement of weight-bearing bones did not seem to affect the association between bone metastases and pain. We discuss the need for periodic bone scintigraphy, even when the clinical state does not seem to warrant it.

Adult↗
PubMed1979

Scintigraphy of abdominal masses with 99mTc-labeled red blood cells.

Scintigraphy with 99mTc-labeled red blood cells was performed in five patients for demonstration of normal anatomy and in 18 patients for evaluation of suspected or apparent space-occupying abdominal lesions. In 14 cases of abdominal lesions, the study demonstrated the extent, vascularity, and relation of the lesion to neighboring organs. We found the method was primarily useful for evaluating cases of retroperitoneal tumor and vascular malformation.

Abdomen↗
PubMed1979

Ultrastructural basis for different pertechnetate uptake patterns by various human brain tumours.

Patterns of pertechnetate uptake were correlated with ultrastructural properties of the endothelial wall in 14 human brain tumours. In tumours with reduced uptake of the radionuclide, intercellular tight junctions were observed whereas absence of intercellular tight junctions was characteristic of all tumours with an increased uptake of pertechnetate. In some tumours with increased uptake, fenestrated endothelial wall was seen while in others non-fenestrated wall was evident. We concluded that intercellular junctions and not fenestrations affect the permeability of brain tumours to pertechnetate.

Astrocytoma↗
PubMed1979

Scintigraphic assessment of technetium 99m-diphosphonate uptake, vascularity and vessel permeability in human bone tumours.

Differences in the rate of uptake of 99Tcm-diphosphonate were found in 20 human bone tumours investigated. As some tumours have a slow rate of uptake it is suggested that the time used for routine scintigraphy at 3 hours is not always optimal and a further study should be performed in some cases. Various degrees of tumour vascularity and vessel permeability were found. The rate of diphosphonate uptake correlates with the vascularity, while it does not correlate with permeability which is generally increased as compared to normal bone.

Bone Neoplasms↗
PubMed1978

Bone scintigraphy in primary tumors of the head and neck.

Bones of the face and skull may be involved directly by adjacent primary tumors of the head and neck. Radiography, at present the standard method for detection of bone involvement in such tumors, is not sufficiently sensitive. Of 22 patients who showed bone involvement in scintigraphy, radiography in 15 was initially normal, in 6 the extent of the lesion was not completely shown and only in 3 was it as informative as scintigraphy. Bone scintigraphy should become a standard method for evaluation of the context of bone invasion by tumors of the head and neck.

Bone and Bones↗
PubMed1978

The value of delayed (24-hour) bone scintigraphy.

Delayed 24-hour scintigraphy was performed in 23 patients. It was found to be useful in enhancing abnormal uptake, enabling better anatomic localization and verifying doubtful uptakes in the 4-hour study. The underlying causes of these observations are probably a better lesion-to-blood ratio and a slow uptake in certain lesions.

Bone Neoplasms↗
PubMed1978

Doughnut phenomenon in bone scintigraphy.

A doughnut phenomenon was observed in bone scintigraphy in three cases of metastatic thyroid carcinoma to the skull. Additional dynamic and static studies were performed to evaluate the relative roles of vascularity, vessel permeability and new bone formation in producing this phenomenon. This was accomplished through the use of 99mTc-diphosphonate, 99mTc-labeled red blood cells and 99mTc-pertechnetate. The important factor was found to be a new bone formation. Late uptake of diphosphonate was shown only in the periphery of the lesion, where formation of new bone takes place. This occurred even in the presence of increased vascularity and vessel permeability in the lesion as a whole.

Adenocarcinoma↗
PubMed1978

Perfusion vascularity mismatch in liver hemangiomas.

Perfusion defect in the dynamic study and slow filling of the lesion by a blood pool agent were observed in three cases with large cavernous hemangiomas of the liver. This finding is explained by the low perfusion and the large blood volume of cavernous hemangiomas. When such a lesion is suspected a late blood pool study should be performed in order to demonstrate the true vascularity of the lesion.

Angiography↗
PubMed1978

Scintigraphic assessment of vascularity and blood-tissue barrier of human brain tumours.

Assessment of vascularity and blood-tissue barrier was performed by sequential scintigraphy in 43 patients with brain tumours. The blood-tumour barrier was evaluated by use of 99mTc-pertechnetate, and vascularity using 99mTc-labelled red blood cells. Three groups of tumours were found: tumours with low vascularity and permeable barrier, tumours with high vascularity and permeable barrier, and tumours with low vascularity and relatively impermeable barrier. The first group indicates that when vessels are permeable, there may be a rapid penetration of large amounts of pertechnetate into the tumour even when vascularity is not increased. In the other two groups penetration of pertechnetate into the tumour is affected by vascularity, as it determines the total area where passage of the radiopharmaceutical takes place. It is suggested that the permeability of the blood-tumour barrier and the amount of vascularity may have an effect on the success of chemotherapy in brain tumours.

Blood-Brain Barrier↗
PubMed1978

Chronic familial hyperphosphatasemia.

Two siblings displaying macrocrania and multiple skeletal deformities, as well as cardiomegaly, had high levels of serum alkaline phosphatase and markedly increased urinary hydroxyproline excretion. The radiological findings of chronic familial hyperphosphatasemia, which are typical of a rare bone-remodeling disease, are presented. Scintigraphy disclosed intense uptake of the radionuclide by the skeletons of both patients. This finding, considered to be related to abnormal collagen metabolism, can be used in the diagnosis and assessment of skeletal involvement in such patients.

Bone and Bones↗
PubMed1978

Bone scintigraphy in scurvy.

Scintigraphic bone changes in two cases of scurvy are described, the cause being subperiosteal hematoma. Generalized increased uptake was shown in the affected femur at an early state of the disease. At a late stage, marked uptake both in the femoral shaft and surrounding tissue was seen causing scintigraphic appearance of widened ("club-shaped") femur.

Child, Preschool↗